SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/APR/2005
Date Updated: 13/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name M-XYLENE, REAGENTPLUS, 99%
Product Number 185566
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
M-XYLENE 108-38-3 203-576-3 601-022-00-9
Formula C8H10
Molecular Weight 106.17 AMU
Synonyms Benzene, 1,3-dimethyl- (9CI) * m-Dimethylbenzene
* 1,3-Dimethylbenzene * m-Methyltoluene *
1,3-Xylene * m-Xylene (ACGIH:OSHA) * m-Xylol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation and in contact with skin.
Irritating to skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 100 mg/m3
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Poland NDSCh 350 mg/m3
Poland NDSP
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 221 mg/m3
50 ppm
Remarks: Skin
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 109 mg/m3
25 ppm
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 108 mg/m3
25 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL TWA 441 mg/m3
100 ppm
OEL STEL 150 ppm
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 137 - 138 癈
MP/MP Range -48 癈
Flash Point 25 癈 Method: closed cup
Flammability N/A
Autoignition Temp 528 癈
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.1 %
Upper: 7 %
Vapor Pressure 16 mmHg 37.7 癈
SG/Density 0.864 g/cm3
Partition Coefficient N/A
Viscosity < 0.001 Pas
Vapor Density 3.7 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
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Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: ZE2275000
ACUTE TOXICITY
LD50
Oral
Rat
5000 mg/kg
LD50
Intraperitoneal
Mouse
2003 UL/KG
LD50
Skin
Rabbit
14100 UL/KG
IRRITATION DATA
Skin
Rabbit
0.01 mg
24H
Remarks: Open irritation test
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
5 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Damage to the liver. Damage to the kidneys. Blood effects.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: Narcotic effect. Lung irritation,
chest pain, and edema which may be fatal. CNS depression.
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Dermatitis. Gastrointestinal disturbances.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves. Liver. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 12 MG/KG
Route of Application: Oral
Exposure Time: (12-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Mouse
Dose: 500 MG/M3/12H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 3000 MG/M3/24H
Route of Application: Inhalation
Exposure Time: (7-14D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 30 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rabbit
Dose: 500 MG/M3/24H
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Route of Application: Inhalation
Exposure Time: (7-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1307
Class: 3
PG: III
Proper Shipping Name: Xylenes
IMDG
UN#: 1307
Class: 3
PG: III
Proper Shipping Name: Xylenes
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1307
Class: 3
PG: III
Proper Shipping Name: Xylenes
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 601-022-00-9
NOTA: C
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 10 20/21 38
Flammable. Harmful by inhalation and in contact with skin.
Irritating to skin.
S-PHRASES: 25
Avoid contact with eyes.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
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NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 7962
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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