SAFETY DATA SHEET
Page 1 of 5
Reviewed on: 22nd October 2008
Product Name: Levicare Hi-Mineral
SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND SUPPLIER
Product name: Levicare Hi Mineral
Product code: A5146
Recommended use: For the control and treatment of roundworms and lungworms in
sheep and cattle. Contains selenium, copper, cobalt, zinc and
iodine.
Company details: Merial Ancare
Address: Level 3, Merial Building
Osterley Way
Manukau City
New Zealand
Telephone number: Phone: +64 9 980 1600 Fax: +64 9 980 1601
Emergency telephone Merial Ancare Freephone: 0800 800 822
number: National Poisons Centre : 0800 764 766 (0800 POISON)
Fire Service, Ambulance : Dial 111
Date of preparation: 10 April 2006
SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS
Chemical characterization: Liquid
Product components:
Name CAS Proportion
Levamisole HCl 16595-80-5 40.0
Copper sulphate pentahydrate 7758-99-8 10.3
Cobalt sulphate heptahydrate 10026-24-1 1.2
Sodium selenate 13410-01-0 1.2
Other to 1L
SECTION 3: HAZARDS IDENTIFICATION
Hazard classifications: 6.1E, 6.3B, 6.5B, 6.6B, 6.9B, 9.1A
Priority and secondary WARNING KEEP OUT OF REACH OF CHILDREN
identifiers: WARNING Dangerous to the environment
Risk and safety phrases: 6.1E May be harmful if swallowed. Handle with care.
6.3B May cause mild skin irritation. Avoid skin contact.
6.5B Repeated exposure may cause skin allergy. Avoid skin contact.
6.6B Levamisole HCl possibly may cause damage to genetic
material. Handle with care.
6.9B Levamisole HCl (blood and haematopoietic system) and copper
sulphate (nephrotoxicity, kidney) possibly may cause organ
damage. Handle with care.
9.1A Very toxic to aquatic organisms. Avoid contamination of any
water supply with product or empty container.
SECTION 4: FIRST AID MEASURES
For advice contact the National Poisons Centre on 0800 POISON
Necessary first aid
(0800 764 766), or a doctor immediately.
measures:
Ingestion: If swallowed seek medical attention. Do NOT induce
vomiting.
Eyes: If splashed in eyes wash out immediately with water.
Skin: If skin or hair contact occurs remove contaminated clothing
and flush skin and hair with running water.
Inhalation: Remove to fresh air.
SAFETY DATA SHEET
Page 2 of 5
Reviewed on: 22nd October 2008
Product Name: Levicare Hi-Mineral
Workplace facilities: No special facilities required.
Required instructions: Observe good work practices and avoid skin contact. Wash hands
and exposed skin before meals and after use. Do not eat or drink
while using. Launder protective clothing separately from other
clothing, and before each reuse.
Notes for medical personnel: Apply symptomatic therapy (no specific antidote).
Note the nature of the product.
SECTION 5: FIRE FIGHTING MEASURES
Type of hazard: Non flammable, Non combustible, Non explosive
Fire hazard properties: Levicare Hi Mineral is not classified as flammable, and will not
support combustion. Hazardous fumes when heated to
decomposition.
Regulatory requirements: Not applicable
Extinguishing media and Treat the fire as for the other materials present. Do not allow water
methods: to enter drains.
Hazchem code: 2X
Recommended protective When fighting a major fire wear full protective clothing including
clothing: breathing apparatus.
SECTION 6: ACCIDENTAL RELEASE MEASURES
Emergency procedures: Wear suitable protective clothing. Restrict access to contaminated
area. Contain the spill and prevent further dispersion. Retrieve
intact containers from site. Place damaged containers into
containment devices. Absorb spills with inert material and place in
waste containers. Wash the area with water and absorb with further
inert material. Collect spilled material and place in sealable
containers for subsequent disposal. Avoid contamination of water
courses or sewers. Dispose of waste safely.
SECTION 7: HANDLING AND STORAGE
Precautions for safe Apply with well-maintained and calibrated equipment. Handle with
handling: care.
Regulatory requirements: N/A
Handling practices: N/A
Approved handlers: Not required
Conditions for safe storage: Store in a cool place below 25癈 with top secured. Keep out of
reach of children.
Store site requirements: This substance is subject to a requirement for an emergency
management plan and secondary containment, whenever it is held
in quantities of 1000L or more. See Hazardous Substances
(Emergency management) regulations 25 to 42.
Packaging: Packaging Schedule 3 (UN Packing Group III) for quantities >5L
(Hazardous Substances Packaging Regulations 2001).
SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTION
Selenium compounds, as Se TWA 0.1mg/m3
Workplace exposure
Copper fume TWA 0.2mg/m3
standards:
Copper dusts & mists, as Cu TWA 1mg/m3
Cobalt metal dust and fume, as Co TWA 0.05mg/m3
Dusts 10mg/m3
SAFETY DATA SHEET
Page 3 of 5
Reviewed on: 22nd October 2008
Product Name: Levicare Hi-Mineral
Application in the workplace: Prevent exposure by using engineering controls, personal protective
equipment and work practices that prevent skin contact.
Exposure standards outside TELs and EELs are not set at this time.
the workplace:
Engineering controls: Ensure that ventilation maintains dust levels below WES.
Personal protection: Clothing should consist of overalls with long sleeves and impervious
gloves.
References: N/A
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Formulation type: Solution
Specify product data:
Appearance: Blue liquid
Specific gravity: 1.0g / mL
Boiling Point: ca. 100?C
Vapour Pressure: NA
Solubility in Water: Actives are soluble in water
Required specifications: N/A
Further specifications: N/A
Specific advice: N/A
SECTION 10: STABILITY AND REACTIVITY
Stability of the substance: Stable under normal conditions of use and storage.
Conditions to avoid: No specific conditions to avoid.
Material to avoid: No specific materials to avoid.
Hazardous decomposition No hazardous products are expected, except when heated to
products: decomposition.
Hazardous polymerization: Components are not expected to form hazardous polymers.
Specific data: N/A
SECTION 11: TOXICOLOGICAL INFORMATION
May be harmful if swallowed. May cause mild skin irritation.
Data and interpretation:
Repeated exposure may cause skin allergy. Danger of serious
damage to health by prolonged exposure if swallowed. Levamisole
HCl possibly may cause damage to genetic material.
Levamisole HCl (blood and haematopoietic system) and copper
sulphate (nephrotoxicity, kidney) possibly may cause organ
damage.
Summaries data: Levamisole HCL: Levamisole is a broad-spectrum anthelmintic with
a long history of use in cattle and sheep. It has moderate to high
acute toxicity [LD50 (oral, rats & mice) = 200-500 mg/kg]. A
potential mutagen [levimisole induced chromosome gaps and
breaks in human lymphocytes in vitro and in vivo and levamisole
hydrochloride induced an increase in the mitotic index, numerical
chromosomal changes (aneuploidy, polyploidy) and structural
chromosomal changes]. Haemolytic anaemic was the main toxic
effect demonstrated in repeated dose animal studies (LOAEL
1.25mg/kg/day). In humans, levamisole has been associated with
various non-specific effects (nausea, vomiting, rashes). Levamisole
has induced leucopenia and agranulocytosis (idiosyncratic) at low
doses.
Sodium selenate: Sodium selenate is acutely toxic [LD50 (oral)
25mg/kg]. Dusts are toxic if inhaled and irritant to eyes. Acute
poisoning exhibits as dyspnea, spasms and death from respiratory
failure. Selenium poisoning in humans has been described and
gastrointestinal and neurological symptoms predominated. Potential
SAFETY DATA SHEET
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Reviewed on: 22nd October 2008
Product Name: Levicare Hi-Mineral
mutagen. Repeated dose testing in laboratory species identified a
lowest NOAEL of 0.37mg/kg/day (liver toxicity).
Cobalt sulphate: Cobalt sulphate is an acute oral toxin [LD50 (oral,
sheep) 330mg/kg ]. Cobalt is a known skin and respiratory
sensitiser. Cobalt sulphate irritates skin, eyes and the respiratory
tract. Cobalt sulphate may cause cancer by long term inhalation
exposure. In repeated dose studies, cobalt salts have been
implicated in cardiac disease (LOAEL 0.02mg/kg/d) and cobalt
sulphate dust caused pulmonary toxicity when inhaled (LOAEL
0.003mg/L/d).
Copper sulphate: Copper sulphate is a mild skin sensitiser. It is
irritating to eyes, skin and the respiratory tract. Not likely to be
toxic at levels used in drenches [LD50 (oral,rat) 960mg/kg ].
Repeated oral dose studies identified nephrotoxicity (NOAEL
25mg/kg) as a critical early target organ effect.
SECTION 12: ENVIRONMENTAL INFORMATION
Very toxic to aquatic organisms.
Potential environmental
interactions:
Data organisation : Levamisole HCl: Levamisole is potentially toxic to terrestrial
vertebrates based on LD50 data [LD50 (oral, rats & mice) = 200-
500mg/kg]. Not toxic to fish or honey bees. Levamisole does not
bioaccumulate in biological systems. In soil, levamisole has a half-
life of five to seventy five days depending on sunlight, soil type and
climatic conditions. Levamisole binds strongly to soil particles and
organic matter. It does not leach in soils and is readily degraded by
hydrolysis and microbial action.
Sodium selenate: Very toxic to fish [LC50 (96hr, Flathead minnow)
690ug/L], to crustacea [LC50 (48hr, Grammarus pseudolimnaeus)
83ug/L] and algae [EC50 (96hr, green algae) 0.2mg/L]. Toxic to
plants [EC20 (22d) 0.1mg/kg soil]. Toxic to terrestrial vertebrates
based on an acute oral LD50(rats) of 25 mg/kg. Selenium is
bioaccumulative and persists.
Cobalt sulphate:Very toxic to aquatic organisms. Not readily
biodegradable, cobalt persists. Toxic to terrestrial vertebrates based
on an acute oral LD50 (sheep) of 330mg/kg.
Copper sulphate:Very toxic to aquatic organisms [LC50 (96hr,
Rainbow trout) 0.032mg/L; EC50 (48hr, Daphnia magna)
0.18mg/L]. Not readily biodegradable, copper persists. Toxic to
terrestrial vertebrates based on an acute oral LD50 (rat) of
960mg/kg.
Environmental risk and ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
safety phrases: (Selenium 0.05%)
SECTION 13: DISPOSAL CONSIDERATIONS
Disposal information : Preferably dispose of the product by use. Otherwise dispose of
product and packaging at an approved landfill or other approved
facility. Burn empty container in an appropriate incinerator, if
circumstances such as wind direction permit. Otherwise crush or
puncture and bury in a suitable landfill. Do NOT use container for
any other purpose.
SECTION 14: TRANSPORT INFORMATION
Dangerous Goods for transport.
Relevant information:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
(Selenium 0.05%)
UN Number: 3082
Dangerous Goods Class: 9
SAFETY DATA SHEET
Page 5 of 5
Reviewed on: 22nd October 2008
Product Name: Levicare Hi-Mineral
The maximum quantity per package of this substance allowed for
carriage on public transport is 1L.
Other requirements: N/A
SECTION 15: REGULATORY INFORMATION
Registered pursuant to the ACVM Act 1997, No. A5146
Regulatory status:
See www.nzfsa.govt.nz/acvm for registration conditions
Approved pursuant to the HSNO Act, Approval Code HSR001933
See www.ermanz.govt.nz for approval conditions
The maximum quantity per package of this substance allowed for
carriage on public transport is 1L.
HSNO and ACVM controls: Refer to Section 3
List exposure limits: None set
SECTION 16: OTHER INFORMATION
Additional information: For product information visit the Merial website www.merial.co.nz
While the information set forth is believed to be accurate as of the
date hereof, MERIAL NZ LTD. makes no warranty with respect
hereto and disclaims all liability from reliance thereon.
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