Material Safety Data Sheet
IDENTIFICATION
Name: Spectrolyse?(pL) PAI Activity
Product Number: 101201
TOXICITY HAZARDS
This product contains reagents that may contain one or more hazardous substances. Only those substances identified as potentially
hazardous are listed.
Reagent/Component Chemical Name CAS Number Percent LD50
not determined - in vivo,
systemic fibrinolysis in
tPA Standard tissue-type plasminogen activator 105857-23-6 < 0.1%
humans at a dose of > 2
mg/kg
tPA Depleted Plasma human plasma 9001-26-7 100% NA
human plasminogen 9001-91-6 < 1.0% NA
Disodium Phosphate 7558-79-4 1% rat, oral ?12.9 g/kg
PAR Reagent Sodium Chloride 7647-14-5 0.9% rat, oral - 3000 mg/kg
para-nitroanaline 100-01-6 < 0.1% rat, oral ?750 mg/kg
poly-D-lysine 56-87-1 NA NA
Sodium Acetate Buffer Sodium Acetate 127-09-3 NA NA
Imidazole Buffer Imidazole 288-34-4 NA mouse, oral ?1880 mg/kg
rat, oral ?750 mg/kg
Tris Buffer Tris 77-86-1 6%
mouse, iv ?1210 mg/kg
HEALTH HAZARD DATA
All of the above listed chemicals may be harmful by inhalation, ingestion or skin absorption. Nasal irritation, eye reddening, and allergic
reactions may result from overexposure.
FIRST AID: If swallowed, wash out mouth with water provided person is conscious. In case of skin
contact, flush with copious amounts of water for at least 15 minutes. Remove
contaminated clothing. In case of contact with eyes, flush with copious amounts of water
for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers.
Seek medical attention.
In case of ingestion, if the victim is conscious, drink several glasses of water or milk to
dilute stomach contents. DO NOT INDUCE VOMITING.
VIRAL SAFETY: The source material for the plasma/serum based reagents have been found to be non-
reactive for Hepatitis B Surface Antigen (HBsAg), Hepatitis C Virus (HCV) and Human
Immunodeficiency Virus Type 1 and Type 2 (HIV-1, HIV-2) using registered methods. As
no known test method can provide complete assurance that products derived from
human blood will not transmit HBsAg, HCV, HIV-1, HIV-2 or other blood-borne
pathogens, this reagent should be handled as recommended for any potentially
infectious human specimen.
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500 West Avenue, P.O. Box 110215, Stamford, CT 06911-0215 Tel. (203) 602-7777 Fax. (203) 602-2221
FIRE & EXPLOSION HAZARD DATA
FLAMMABILITY: Solutions are non-flammable. Boxing, instruction papers and powdered reagents are
flammable.
EXTINGUISHING MEDIA: Carbon dioxide, dry chemical powder or appropriate foam.
SPECIAL FIRE FIGHTING Wear self-contained breathing apparatus and protective clothing to prevent contact with
PROCEDURES: skin.
REACTIVITY DATA
HAZARDOUS COMBUSTION May produce carbon monoxide, carbon dioxide.
OR DECOMPOSITION PRODUCTS
HAZARDOUS POLYMERIZATION: Does not occur.
SPILL, LEAK and DISPOSAL PROCEDURES
STEPS TO BE TAKEN IF Sweep up, place in a bag and hold for waste disposal. Avoid raising dust.
MATERIAL IS RELEASED Ventilate area and wash spill site after material pickup is complete. In case of
OR SPILLED skin contact, flush with copious amounts of water and remove contaminated clothing.
WASTE DISPOSAL METHOD: Sweep up and place in a covered waste disposal container. Observe all federal, state
and local environmental regulations.
PRECAUTIONS TO BE Wear appropriate NIOSH/MSHA approved respirator, chemical resistant gloves,
TAKEN IN HANDLING safety goggles. Do not breathe dust. Avoid contact with eyes, skin and clothing.
AND STORAGE Wash thoroughly after handling.
TRANSPORT INFORMATION Proper shipping name: None
DOT: This substance is considered non-hazardous for transport.
IATA: Non-hazardous for air-freight.
The above information is believed to be correct, but does not claim to be complete or inclusive. It shall only serve as a guide for handling
purposes. American Diagnostica Inc. shall not be held liable for any damage resulting from handling or from contact with the above
product.
?ADI040129
500 West Avenue, P.O. Box 110215, Stamford, CT 06911-0215 Tel. (203) 602-7777 Fax. (203) 602-2221
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