p-Nitrophenol
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General Properties
Product: p-Nitrophenol
Synonym: 4-Nitrophenol; 4-Hydroxynitrobenzene
Catalog Number: 102461, 102465, 210357
Chemical Formula: C6H5NO3
Physical Description: Pale yellow crystalline powder
Melting Point: 113-114oC
Boiling Point: 279oC
Specific Gravity: 1.270 @ 120oC
Vapor Pressure: 0.6mm @ 120oC; 6.9mm @ 165oC
Solubility in Water: Soluble
TLV of the Substance: Not Available
Storage: Room Temperature
Remarks
Toxic!
UN 1663 Nitrophenols (o-, m-, p-) (III)
Toxicity Data: orl-mus LD50: 380 mg/kg
ipr-mus LD50: 75 mg/kg
orl-rat LD50: 250 mg/kg
CAS # 100-02-7 RTECS # SM2275000 UN # 1663 (III)
WHMIS # D2A
Dangerous Reactions
Flammability: Slight
Flash Point (method): 169oC
Minimum Ignition Temperature: 541oF
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Risk of explosion? No Unusual Hazard, but see dangerous reactions below.
Decomposition of the substance when heated or burned: YES,
Toxic Fumes of CO, CO2 and NOx.
Any Dangerous Reactions? Strong oxidizing agents and Strong Bases. Mixtures
with diethyl phosphite may explode when heated.
Extinguishing Media: CO2, dry chemical, or foam
Toxicological Data
Route(s) of Entry:
Inhalation: YES
Skin: YES
Ingestion: YES
Health Hazards - Acute and Chronic: Toxic by ingestion. Possible mutagen.
Targets the blood and central nervous system. Irritant. Moderately toxic by skin
contact.
Signs and Symptoms of Exposure: Irritation, cyanosis, headache, nausea,
dizziness, shortness of breath, bluish discoloration of lips and fingernails.
Safe Handling and Safe Use of Materials
Spill or Release of Material
[ ] Absorb the liquid in dry sand, diatomite, vermiculite or other drying agent then
shovel into suitable containers for disposal.
[ ] Acid Spills - Depending upon the situation neutralize with soda ash then use one
of the following methods; soak up in an absorbent then shovel into suitable container
for disposal, or flush away with a liberal amount of water.
[ ] Alkaline Spills - Depending upon the situation neutralize with NaHSO4 and then
use one of the following methods; soak up in an absorbent then shovel into suitable
container for disposal, or flush away with a liberal amount of water.
[X] Other procedures: Sweep into suitable container for disposal.
Waste Disposal Method:
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Incinerate or landfill as complies with state and local laws.
Handling
Always wear gloves, mask, goggles or other protective clothing and use a hood.
Follow proper laboratory procedures.
Personal Protection
Respiratory Protection: YES
Eye Protection: YES
Protective Gloves: YES
Is a local exhaust system required when the substance is used for its normal purpose?
YES
First Aid Procedures
Substance in Contact with Skin
[X] Remove contaminated clothing and rinse with copious amounts of soap and
water for a considerable amount of time
[ ] Produces severe caustic burns or general disorders, call a physician
[X] Call a physician
[ ] Not Hazardous
Substance has been Swallowed
[ ] Rinse mouth several times with water, do not swallow
[X] Drink 1 or 2 glasses of water within 15 minutes
[X] Induce vomiting
[ ] In the case of imminent unconsciousness clear the respiratory tract and lay patient
on side in a stable position
[X] Always Call a physician or take patient to hospital
[ ] Not Hazardous
Substance in Contact with Eyes
[X] Rinse liberally with water for a considerable amount of time
[X] Always call a physician or take to a hospital
[ ] Not Hazardous
Substance has been Inhaled
[X] Take patient into the fresh air and allow to rest
[ ] In the case of imminent unconsciousness clear the respiratory tract and lay patient
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on side in a stable position
[X] Always Call a physician or take patient to hospital
Additional Instructions:
Observe proper laboratory procedures when handling material.
Regulatory Information
TSCA (Toxic Substance Control Act): Listed
SARA
302: Yes
313: Yes
Date of Preparation: 04/09/2001
The information provided with this MSDS is furnished in good faith and without
warranty of any kind. Personnel handling this material must consider these data only
as supplemental to other information gathered by them and must make independent
determinations of this suitability and completeness of information from all sources to
assure proper use and disposal of the materials and the safety and health of
employees and customers. ICN assumes no additional liability or responsibility
resulting from the use of, or reliance on this information.
SARA 313 Notification
The purpose of this letter is to inform you that the product(s) listed on the attached MSDS is either subject to
or contains a chemical subject to the requirements of section 313 of the Emergency Planning and community
Right-To-Know Act of 1986. This law requires certain manufacturers and end users to report on annual
emissions of specified toxic chemicals and chemical categories. This notification satisfies the US Code of
Federal Regulations (40 CFR Part 372).
If you are unsure if you are subject to the reporting requirements of section 313, or need more information,
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please call the EPA Emergency Planning and Community Right-To-Know Information Hotline: (800)
535-0202 or (202) 479-2449 (In Washington, DC or Alaska).
Please note that if you repackage or distribute this product to industrial customers, a notice similar to this one
should be sent to those customers.
Please keep this letter attached to the MSDS.
ICN Technical Service
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