SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 05/02/2008
Date Updated: 01/26/2006
Version 1.4
Section 1 - Product and Company Information
Product Name 4-NITROANILINE, 99+%
Product Number 185310
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
4-NITROANILINE 100-01-6 Yes
Formula C6H6N2O2
Synonyms p-Aminonitrobenzene * 1-Amino-4-nitrobenzene *
Aniline, 4-nitro- * Azoamine Red ZH * Azoic Diazo
Component 37 * Benzenamine, 4-nitro- (9CI) * C.I.
37035 * C.I. Azoic Diazo Component 37 * C.I.
Developer 17 * Developer P * Devol Red GG * Diazo
Fast Red GG * Fast Red Base GG * Fast Red Base 2J
* Fast Red 2G Base * Fast Red GG Base * Fast Red
MP Base * Fast Red P Base * Naphtoelan Red GG
Base * NCI-C60786 * p-Nitraniline * 4-Nitraniline
* Nitrazol CF Extra * p-Nitroanilina (Polish) *
p-Nitroaniline (ACGIH:OSHA) * 4-Nitroaniline *
4-Nitrobenzenamine * p-Nitrophenylamine * PNA *
RCRA waste number P077 * Red 2G Base * Shinnippon
Fast Red GG Base
RTECS Number: BY7000000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
Toxic by inhalation, in contact with skin and if swallowed. Danger
of cumulative effects. Irritating to eyes, respiratory system and
skin. Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
Target organ(s): Blood. Liver. Causes cyanosis. Readily absorbed
through skin.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
415.4 癋 213 癈 Method: closed cup
AUTOIGNITION TEMP
180 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
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HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face particle respirator type N99 (US) or
type P2 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a
full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 3 MG/M3
Remarks: Skin
USA MSHA Standard-air TWA 1 PPM (6 MG/M3) (SKIN)
USA OSHA. PEL 8H TWA 1 PPM (6 MG/M3) (SKIN)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 3 MG/M3 (SK)
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 3 MG/M3
Poland NDSCh 10 MG/M3
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Color: Yellow
Form: Fine crystals
Odor: Ammonia odor
Property Value At Temperature or Pressure
Molecular Weight 138.13 AMU
pH 6.7
BP/BP Range 260 癈 100 mmHg
MP/MP Range 146 癈
Freezing Point N/A
Vapor Pressure 0.004 mmHg 25 癈
Vapor Density 4.77 g/l
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Saturated Vapor Conc. N/A
SG/Density 1.44 g/cm3
Bulk Density 630 kg/l
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 1.39
Decomposition Temp. N/A
Flash Point 415.4 癋 213 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 180 癈
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: This product generates heat as it absorbs
moisture or water. Moisture.
Materials to Avoid: Strong acids, Strong oxidizing agents, Strong
reducing agents, Plastics, Rubber.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Liver. Lungs. Heart. Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Nausea. Drowsiness. Coughing, chest pains, difficulty in
breathing. Unconsciousness. Headache. Cyanosis. p-Nitroaniline
is readily absorbed by inhalation, ingestion, or skin
absorption. It is a strong methemoglobin former. Cyanosis is the
first manifestation of toxicity. To the best of our knowledge,
the chemical, physical, and toxicological properties have not
been thoroughly investigated. Vomiting. Diarrhea. Ataxia.
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Exposure can cause: Exposure to and/or consumption of alcohol
may increase toxic effects. Absorption into the body leads to
the formation of methemoglobin which in sufficient concentration
causes cyanosis. Onset may be delayed 2 to 4 hours or longer.
TOXICITY DATA
Oral
Rat
750 mg/kg
LD50
Oral
Mouse
810 mg/kg
LD50
Intraperitoneal
Mouse
250 MG/KG
LD50
Intramuscular
Mouse
800 MG/KG
LD50
Oral
Guinea pig
450 mg/kg
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Somnolence (general depressed activity).
Skin
Guinea pig
> 500 mg/kg
LD50
Oral
Quail
1000 mg/kg
LD50
Oral
Bird (wild)
75 mg/kg
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Mouse
Route of Application: Oral
Dose: 51500 MG/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Vascular:Tumors.
NTP CARCINOGEN LIST
Rating: Equivocal evidence.
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Species: Mouse
Route: Gavage
ACGIH CARCINOGEN LIST
Rating: A4
CHRONIC EXPOSURE - MUTAGEN
Species: Hamster
Dose: 173 MG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 1600 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 1764 MG/KG
Route of Application: Oral
Exposure Time: (14W MALE/14W PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Mouse
Dose: 9600 MG/KG
Route of Application: Oral
Exposure Time: (6-13D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Fertility: Litter size (e.g.; # fetuses
per litter; measured before birth). Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Time: 24 h
Value: 68 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 17 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 85.7 - 142.0 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 35 mg/l
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Test Type: LC50 Fish
Species: Brachydanio rerio
Time: 96 h
Value: 87.6 mg/l
ADDITIONAL RESULTS/DATA FROM RELEVENT SCIENTIFIC EXPERIMENTS
Avoid contamination of the environment
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Nitroanilines [(o-; m-; p-;)]
UN#: 1661
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Nitroanilines
IATA UN Number: 1661
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 23/24/25-33-52/53
Risk Statements: Toxic by inhalation, in contact with skin and
if swallowed. Danger of cumulative effects. Harmful to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
S: 28-36/37-45-61
Safety Statements: After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible). Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic.
Risk Statements: Toxic by inhalation, in contact with skin and
if swallowed. Danger of cumulative effects. Irritating to eyes,
respiratory system and skin. Harmful to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
Safety Statements: After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
ALDRICH - 185310 www.sigma-aldrich.com Page 7
advice immediately (show the label where possible). Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Liver. Blood. Causes cyanosis.
Readily absorbed through skin.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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