METHYLENE BLUE Page 1 of 7
METHYLENE BLUE
MSDS Number: M4381 --- Effective Date: 01/19/98
1. Product Identification
Synonyms: Basic Blue 9,trihydrate; Methelyne blue trihydrate; 3,7-Bis(dimethylamino)
phenazathionium chloride trihydrate
CAS No.: 61-73-4
Molecular Weight: 373.91
Chemical Formula: C16H18ClN3S . 3H2O
Product Codes:
J.T. Baker: 2702, Q473, Q475
Mallinckrodt: 5891
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Methylene Blue 61-73-4 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 1 - Slight
Flammability Rating: 0 - None
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT
Storage Color Code: Orange (General Storage)
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Potential Health Effects
----------------------------------
This material is relatively nonhazardous in routine industrial situations.
Inhalation:
No adverse health effects expected from inhalation. May cause a short period of rapid or
difficult breathing.
Ingestion:
A burning sensation of the mouth may be noted following ingestion of methylene blue.
May cause nausea, vomiting, diarrhea, and gastritis. Large doses may cause abdominal
and chest pain, headache, profuse sweating, mental confusion, painful micturation, and
methemoglobinemia.
Skin Contact:
Not expected to be a health hazard from skin exposure. Methylene blue may color the
skin a bluish color. May cause photosensitization.
Eye Contact:
No adverse effects expected. May cause mechanical irritation.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
4. First Aid Measures
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by
mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes
before reuse. Get medical attention if irritation develops.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and
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lower eyelids occasionally. Get medical attention if irritation persists.
5. Fire Fighting Measures
Fire:
Methylene blue does not burn. Not considered to be a fire hazard.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained
breathing apparatus with full facepiece operated in the pressure demand or other positive
pressure mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Wear appropriate personal protective equipment as
specified in Section 8. Spills: Pick up and place in a suitable container for reclamation or
disposal, using a method that does not generate dust.
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against
physical damage. Avoid dust formation and control ignition sources. Isolate from
incompatible substances. Containers of this material may be hazardous when empty since
they retain product residues (dust, solids); observe all warnings and precautions listed for
the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
None established.
Ventilation System:
In general, dilution ventilation is a satisfactory health hazard control for this substance.
However, if conditions of use create discomfort to the worker, a local exhaust system
should be considered.
Personal Respirators (NIOSH Approved):
Not expected to require personal respirator usage. For conditions of use where exposure
to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For
emergencies or instances where the exposure levels are not known, use a full-face
positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not
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protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions
is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Dark green crystals with bronze luster or crystalline powder.
Odor:
Odorless.
Solubility:
Soluble in water.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
Decomposes.
Melting Point:
100 - 110C (212 - 230F)
Vapor Density (Air=1):
13
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
May produce oxides of nitrogen, sulfur and carbon when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents, alkali, dichromates, alkali iodides, reducing agents.
Conditions to Avoid:
Heat, flame, ignition sources, dusting and incompatibles.
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11. Toxicological Information
Methylene Blue: 1180 mg/kg LD50 oral rat. Investigated as a mutagen, reproductive
effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Methylene Blue (61-73-4) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material is not expected to evaporate significantly. When
released into water, this material is not expected to evaporate significantly. This material
has an estimated bioconcentration factor (BCF) of less than 100. This material is not
expected to significantly bioaccumulate. When released into the air, this material is
expected to be readily degraded by reaction with photochemically produced hydroxyl
radicals. When released into the air, this material may be removed from the atmosphere to
a moderate extent by wet deposition. When released into the air, this material may be
removed from the atmosphere to a moderate extent by dry deposition.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate
and approved waste disposal facility. Processing, use or contamination of this product
may change the waste management options. State and local disposal regulations may
differ from federal disposal regulations. Dispose of container and unused contents in
accordance with federal, state and local requirements.
14. Transport Information
Not regulated.
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
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----------------------------------------------- ---- --- ----- ---------
Methylene Blue (61-73-4) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Methylene Blue (61-73-4) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Methylene Blue (61-73-4) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Methylene Blue (61-73-4) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: No information found.
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 0 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED.
Label Precautions:
Wash thoroughly after handling.
Avoid contact with eyes, skin and clothing.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 1, 3, 4, 5, 6, 7, 8, 9,
10, 12, 15, 16.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith
but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling of
the material by a properly trained person using this product. Individuals receiving
the information must exercise their independent judgment in determining its
appropriateness for a particular purpose. MALLINCKRODT BAKER, INC.
MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR
IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH
RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT
TO WHICH THE INFORMATION REFERS. ACCORDINGLY,
MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR
DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
***************************************************************************************
Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)
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