Brucine Sulfate, 7-Hydrate Page 1 of 7
Brucine Sulfate, 7-Hydrate
MSDS Number: B5620 --- Effective Date: 12/08/96
1. Product Identification
Synonyms: 10,11-Dimethoxystrychnine Sulfate, 7-Hydrate
CAS No.: 4845-99-2
Molecular Weight: 1013.13
Chemical Formula: (C23H26N2O4)2.H2SO4.7H2O
Product Codes: D545
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Brucine sulfate 4845-99-2 90 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
POISON! DANGER! MAY CAUSE IRRITATION. MAY BE FATAL IF SWALLOWED.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 4 - Extreme (Poison)
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Flammability Rating: 0 - None
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
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Potential Health Effects
----------------------------------
Inhalation:
Is harmful may be fatal.
Ingestion:
Nausea, vomiting, may be fatal.
Skin Contact:
None identified.
Eye Contact:
Irritation.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
4. First Aid Measures
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Prompt action is essential.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious
person. Get medical attention.
Skin Contact:
In case of contact, flush skin with water.
Eye Contact:
In case of eye contact, immediately flush with plenty of water for at least 15 minutes.
5. Fire Fighting Measures
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Fire:
Not expected to be a fire hazard.
Explosion:
Closed containers exposed to heat may explode.
Fire Extinguishing Media:
Use extinguishing media appropriate for surrounding fire.
Special Information:
Firefighters should wear proper protective equipment and self-contained breathing apparatus with full facepiece
operated in positive pressure mode. Move exposed containers from fire area if it can be done without risk. Use
water to keep fire-exposed containers cool.
6. Accidental Release Measures
Wear self-contained breathing apparatus and full protective clothing. With clean shovel, carefully place material
into clean, dry container and cover; remove from area. Flush spill area with water.
7. Handling and Storage
Keep container tightly closed. Store in secure poison area. Containers of this material may be hazardous when
empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the
product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local
exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source,
preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial
Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the substance is apparent, consult an industrial hygienist. For
emergencies, or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-
supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient
atmospheres.
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Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to
prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain
eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
White Crystalline solid.
Odor:
No information found.
Solubility:
Moderate (1-10%)
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
No information found.
Melting Point:
No information found.
Vapor Density (Air=1):
Not applicable.
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
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Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Oxides of sulfur, oxides of nitrogen, carbon monoxide, carbon dioxide.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents.
Conditions to Avoid:
No information found.
11. Toxicological Information
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Brucine sulfate (4845-99-2) No No None
12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste
disposal facility. Processing, use or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal regulations. Dispose of container and
unused contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
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Proper Shipping Name: ALKALOID SALTS, SOLID, N.O.S. (BRUCINE SULFATE, 7-HYDRATE)
Hazard Class: 6.1
UN/NA: UN1544
Packing Group: II
Information reported for product/size: 25G
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ALKALOID SALTS, SOLID, N.O.S. (BRUCINE SULFATE, 7-HYDRATE)
Hazard Class: 6.1
UN/NA: UN1544
Packing Group: II
Information reported for product/size: 25G
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: ALKALOID SALTS, SOLID, N.O.S. (BRUCINE SULFATE, 7-HYDRATE)
Hazard Class: 6.1
UN/NA: UN1544
Packing Group: II
Information reported for product/size: 25G
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Brucine sulfate (4845-99-2) Yes Yes No Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Brucine sulfate (4845-99-2) No Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Brucine sulfate (4845-99-2) No No No Strychnine s
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Brucine sulfate (4845-99-2) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
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Australian Hazchem Code: 2X
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR)
and the MSDS contains all of the information required by the CPR.
16. Other Information
Label Hazard Warning:
POISON! DANGER! MAY CAUSE IRRITATION. MAY BE FATAL IF SWALLOWED.
Label Precautions:
Do not get in eyes, on skin, on clothing. Keep in tightly closed container. Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person. In case of contact, immediately flush eyes or skin with plenty of water for at least 15
minutes.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no
representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment in determining its
appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO
REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING
WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR
THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT
BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR
RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)
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