SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 05/DEC/2004
Date Updated: 17/MAR/2004
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-MERCAPTOETHANOL (2ME) (WORLDWIDE
EXCEPT NORTH AMERICA)
Product Number 516732
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-MERCAPTOETHANOL 60-24-2 200-464-6 None
Formula C2H6OS
Molecular Weight 78.13 AMU
Synonyms Emery 5791 * 1-Ethanol-2-thiol * Ethylene
glycol, monothio- * 2-Hydroxy-1-ethanethiol *
2-Hydroxyethyl mercaptan * 2-ME *
Mercaptoethanol * beta-Mercaptoethanol *
2-Mercaptoethanol * Monothioethyleneglycol *
2-Thioethanol * Thiomonoglycol * USAF EK-4196
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Toxic in contact with skin. Causes burns.
Toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat and open flame.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling. Discard contaminated shoes.
EXPOSURE LIMITS
Country Source Type Value
USA 10 ppm
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Odor: Stench.
Property Value At Temperature or Pressure
pH 4-6 20 掳C
BP/BP Range 157 掳C 760 mmHg
MP/MP Range < -50 掳C
Flash Point 77 掳C Method: closed cup
Flammability N/A
Autoignition Temp 295 掳C 760 mmHg
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.3 %
Upper: 18 %
Vapor Pressure 0.76 mbar 20 掳C
SG/Density 1.115 g/cm3
Partition Coefficient Log Kow: -0.326
Viscosity N/A
Vapor Density 2.69 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.5 M in H2O, 20掳C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Sensitive to moisture. Heat.
Materials to Avoid: Oxidizing agents Avoid contact with metals.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Sulfur oxides Carbon monoxide,
Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: KL5600000
ACUTE TOXICITY
LD50
Oral
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Rat
244 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity. Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Oral
Mouse
190 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity. Lungs, Thorax, or Respiration:Respiratory depression.
LC50
Inhalation
Mouse
13,200 mg/m3
Remarks: Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Intraperitoneal
Mouse
200 MG/KG
LD50
Skin
Rabbit
150 UL/KG
LD50
Skin
Guinea pig
300 UL/KG
IRRITATION DATA
Skin
Rabbit
10 mg
24H
Remarks: Open irritation test
Eyes
Rabbit
2 mg
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure may cause: Weakness. Nausea. Unconsciousness.
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
ALDRICH - 516732 www.sigma-aldrich.com Page 4
respiratory tract.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Rat
1 MMOL/L
Cell Type: liver
DNA inhibition
Mouse
100 MG/L
Cell Type: Other cell types
Micronucleus test
Mouse
30 MMOL/L
Cell Type: Other cell types
Unscheduled DNA synthesis
12 - Ecological Information
ELIMINATION
Elimination: 6 %
Classification: Not significantly biodegradable.
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 96 h
Value: > 46 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 48 h
Value: 1.52 mg/l
Test Type: EC50 Algae
Time: 72 h
Value: 12 mg/l
Test Type: LC50 Bacteria
Time: 17 h
Value: 125 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2966
Class: 6.1
PG: II
Proper Shipping Name: Thioglycol
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IMDG
UN#: 2966
Class: 6.1
PG: II
Proper Shipping Name: Thioglycol
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2966
Class: 6.1
PG: II
Proper Shipping Name: Thioglycol
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 22 24 34 51/53
Harmful if swallowed. Toxic in contact with skin. Causes burns.
Toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
S-PHRASES: 26 36/37/39 45 60
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show
the label where possible). This material and its container must
be disposed of as hazardous waste.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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