SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 06/DEC/2004
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BARBITAL SODIUM DEA SCHEDULE IV ITEM
Product Number B0500
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BARBITOL SODIUM 144-02-5 205-613-9 None
Formula C8H11N2NaO3
Molecular Weight 206.2 AMU
Synonyms Barbital Na * Barbital sodium * Barbital, sodium
deriv. * Barbital soluble * Barbitone sodium *
Barbitone, sodium deriv. * Diethylbarbiturate
monosodium * 5,5-Diethylbarbituric acid sodium
deriv. * Diethylmalonylurea sodium * Embinal *
Medinal * Natrinal * Natriumbarbitals (German) *
Nervoseton * 2,4,6(1H,3H,5H)-Pyrimidinetrione,
5,5-diethyl-, monosodium salt (9CI) * Sodium
barbital * Sodium barbitone * Sodium
diethylbarbiturate * Sodium
5,5-diethylbarbiturate * Sodium ethylbarbital *
Sodium malonylurea * Sodium veronal * Soluble
barbital * Soprinal * Thyalone * Veronal sodium
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH 9 - 10.5
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 0.625 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.5 M in H2O, 20藲C
complete, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CQ3850000
ACUTE TOXICITY
LD50
Oral
Rat
600 mg/kg
LD50
Intravenous
Rat
280 mg/kg
TDLo
Intraperitoneal
Rat
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300 mg/kg
TDLo
Subcutaneous
Rat
300 mg/kg
LD50
Oral
Rat
600 mg/kg
LD50
Intraperitoneal
Rat
300 MG/KG
LD50
Intravenous
Rat
280 MG/KG
LD50
Oral
Mouse
800 mg/kg
LD50
Intraperitoneal
Mouse
620 MG/KG
LD50
Subcutaneous
Mouse
700 MG/KG
LD50
Intravenous
Mouse
830 MG/KG
LD50
Intraperitoneal
Rabbit
250 MG/KG
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Effects of overexposure include sedation, hypnosis, and coma
depending upon amount ingested. Has been implicated in the
development of aplastic anemia. Prolonged or repeated exposure
can lead to habituation or addiction.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
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Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 72W
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Kidney tumors.
Rat
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Kidney tumors.
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Mouse
Dose: 390 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 690 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 200 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 2400 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Embryo or Fetus: Fetotoxicity
(except death, e.g., stunted fetus).
Species: Rat
Dose: 2600 MG/KG
Route of Application: Subcutaneous
Exposure Time: (7-19D PREG)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
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Dose: 6 GM/KG
Route of Application: Subcutaneous
Exposure Time: (20D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 125 MG/KG
Route of Application: Unreported
Exposure Time: (19D PREG)
Result: Effects on Newborn: Behavioral.
Species: Mouse
Dose: 390 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 120 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Mouse
Dose: 240 MG/KG
Route of Application: Parenteral
Exposure Time: (3D PRE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact the Drug Enforcement Administration concerning the
disposal of controlled substances. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
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16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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