SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 25/NOV/2004
Date Updated: 28/MAY/2004
Version 1.2
According to 91/155/EEC
1 - Product and Company Information
Product Name (+/-)-ATENOLOL
Product Number A139
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(+/-)-ATENOLOL 29122-68-7 249-451-7 None
Formula C14H22N2O3
Molecular Weight 266.3 AMU
Synonyms Atenolol * Benzeneacetamide,
4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
(9CI) *
1-p-Carbamoylmethylphenoxy-3-isopropylamino-2-pro
panol * Duraatenolol *
2-(p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)
acetamide *
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benz
eneacetamide * ICI 66082 * Normiten * Tenormin *
Tenormine (French)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
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Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AC3600000
ACUTE TOXICITY
LD50
Oral
Rat
> 2000 mg/kg
LD50
Subcutaneous
Rat
>600 MG/KG
LD50
Intravenous
Rat
77 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Other changes.
LD50
Oral
Mouse
2000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea.
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LD50
Intraperitoneal
Mouse
134 MG/KG
LD50
Subcutaneous
Mouse
>400 MG/KG
LD50
Intravenous
Mouse
57 MG/KG
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage).
LD50
Intravenous
Rabbit
50 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 2200 MG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rabbit
Dose: 5200 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 260 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 16 MG/KG
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Route of Application: Oral
Exposure Time: (5D POST)
Result: Effects on Newborn: Other postnatal measures or effects.
Species: Woman
Dose: 630 MG/KG
Route of Application: Oral
Exposure Time: (90W PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Maternal Effects: Breasts, lactation (prior to or during
pregnancy). Maternal Effects: Other effects.
Species: Woman
Dose: 434 MG/KG
Route of Application: Oral
Exposure Time: (5-36W PREG)
Result: Tumorigenic Effects: Uterine tumors.
Species: Rat
Dose: 22 GM/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Rat
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (17-22D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 2 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
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IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
S-PHRASES: 22 24/25
Do not breathe dust. Avoid contact with skin and eyes.
Not hazardous according to Directive 67/548/EC.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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