SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 25/NOV/2004
Date Updated: 12/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ATROPINE FREE BASE CRYSTALLINE
Product Number A0132
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ATROPINE 51-55-8 200-104-8 614-010-00-3
Formula C17H23NO3
Molecular Weight 289.4 AMU
Synonyms Atropin (German) * Atropina (Italian) *
Atropin-flexiolen * Atropinol * Eyesules *
alpha-(Hydroxymethyl)benzeneacetic acid
8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester *
dl-Hyoscyamine * Isopto-atropine *
2-Phenylhydracrylic acid 3-alpha-tropanyl ester
*
beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester
(German) * 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol
(+-)-tropate (ester) (8CI) * DL-Tropanyl
2-hydroxy-1-phenylpropionate * Tropic acid,
ester with tropine * Tropic acid,
3-alpha-tropanyl ester * Tropine tropate *
(+,-)-Tropyl tropate * dl-Tropyltropate
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic by inhalation and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
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9 - Physical and Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 115 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Sensitive to light.
Materials to Avoid: Alkalis, iodine, mercury salts, tannic acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: CK0700000
ACUTE TOXICITY
LD50
Oral
Rat
500 mg/kg
LD50
Oral
Mouse
75 mg/kg
LD50
Oral
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Rabbit
600 mg/kg
LD50
Oral
Rat
500 mg/kg
LD50
Intraperitoneal
Rat
280 MG/KG
LD50
Subcutaneous
Rat
250 MG/KG
LD50
Intravenous
Rat
73 MG/KG
LD50
Intramuscular
Rat
920 MG/KG
LD50
Oral
Mouse
75 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Intraperitoneal
Mouse
30 MG/KG
LD50
Subcutaneous
Mouse
428 MG/KG
LD50
Intravenous
Mouse
30 MG/KG
LD50
Intradermal
Mouse
550 MG/KG
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Oral
Rabbit
600 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
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Thorax, or Respiration:Dyspnea.
LD50
Intravenous
Rabbit
50 MG/KG
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Intradermal
Rabbit
500 MG/KG
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Oral
Guinea pig
1100 mg/kg
LD50
Intraperitoneal
Guinea pig
400 MG/KG
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be fatal if inhaled. Material may be irritating
to mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Nerves. Heart. Eyes.
CHRONIC EXPOSURE - TERATOGEN
Species: Woman
Dose: 20 UG/KG
Route of Application: Intravenous
Exposure Time: (26-39W PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 1600 UG/KG
Route of Application: Unreported
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
12 - Ecological Information
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No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1544
Class: 6.1
PG: I
Proper Shipping Name: Alkaloids, solid, n.o.s.
IMDG
UN#: 1544
Class: 6.1
PG: I
Proper Shipping Name: Alkaloids, solid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1544
Class: 6.1
PG: I
Proper Shipping Name: Alkaloids, solid, n.o.s.
Inhalation Packing Group I: Yes
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 614-010-00-3
INDICATION OF DANGER: T+
Very toxic.
R-PHRASES: 26/28
Very toxic by inhalation and if swallowed.
S-PHRASES: 25 45
Avoid contact with eyes. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
SIGMA - A0132 www.sigma-aldrich.com Page 6
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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