SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 03/FEB/2005
Date Updated: 30/NOV/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BENZYL CHLORIDE
Product Number 13270
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BENZYL CHLORIDE 100-44-7 202-853-6 602-037-00-3
Formula C7H7Cl
Molecular Weight 126.59 AMU
Synonyms Benzene, (chloromethyl)- * Benzile (cloruro di)
(Italian) * Benzyl chloride (ACGIH:OSHA) *
Benzyle (chlorure de) (French) * Benzylchlorid
(German) * Chloromethylbenzene *
Chlorophenylmethane * alpha-Chlorotoluene *
omega-Chlorotoluene * alpha-Chlortoluol (German)
* Chlorure de benzyle (French) * NCI-C06360 *
RCRA waste number P028 * Tolyl chloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Harmful if swallowed. Toxic by inhalation.
Irritating to respiratory system and skin. Risk of serious damage
to eyes. Harmful: danger of serious damage to health by prolonged
exposure if swallowed.
Carc. Cat.3 Carc. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Stabilized and unstabilized benzyl chloride
will undergo a rapid, exothermic polymerization reaction above
212掳F (100掳C). This reaction occurs at much lower temperatures
when species of iron are present. The gases generated during
rapid polymerization will result in rapid build-up of dangerous
pressure in closed vessels
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Moisture sensitive.
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8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 3 MG/M3
Poland NDSCh -
Poland NDSP 5 MG/M3
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 5 mg/m3
1 ppm
Remarks: LK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.2 mg/m3
Remarks: 4
Remarks: TRK,32,TRGS 901-75
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 5 mg/m3
1 ppm
Remarks: TK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level5 mg/m3
1 ppm
Remarks: K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1 ppm
0.2mg/m3*
Remarks: K
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 2.6 mg/m3
0.5 ppm
OEL STEL 7.9 mg/m3
1.5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
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Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 65 - 67 掳C 11 mmHg
MP/MP Range -43 - -39 掳C
Flash Point 60 掳C Method: closed cup
Flammability N/A
Autoignition Temp 585 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.1 %
Upper: 14 %
Vapor Pressure 10.3 mmHg 60 掳C
SG/Density 1.098 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 4.36 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Decomposes easily
Conditions to Avoid: Loss of inhibitor Moisture.
Materials to Avoid: Contact with common metals (except nickel and
lead) or moisture produces a Friedel-Crafts, condensation-type
reaction with the liberation of heat and formation of toxic and
corrosive hydrogen chloride. Hydrolyzes very slowly to form
hydrogen chloride and benzyl alcohol. This product is not
sensitive to physical impact. When stabilized with propylene
oxide, the possibility of a Friedel-Crafts type reaction is
minimized. Depletion of the stabilizer increases the possibility
of condensation reactions, Oxidizing agents Iron and iron salts.,
Brass, Aluminum
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
STABILIZERS PRESENT
Inhibited with 0.25% propylene oxide
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur
11 - Toxicological Information
RTECS NUMBER: XS8925000
ACUTE TOXICITY
LC50
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Inhalation
Rat
4,085 mg/kg
4H
LD50
Oral
Rat
1231 mg/kg
LC50
Inhalation
Rat
150 ppm
2H
Remarks: Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Subcutaneous
Rat
1 GM/KG
LD50
Oral
Mouse
1500 mg/kg
LC50
Inhalation
Mouse
80 ppm
2H
Remarks: Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Oral
Mammal
1500 mg/kg
LC50
Inhalation
Mammal
390 mg/m3
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: Toxic if inhaled. Material is extremely destructive
to the tissue of the mucous membranes and upper respiratory
tract.
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Ingestion: Harmful if swallowed. Ingestion can cause immediate
burning pain in the mouth, throat, abdomen; severe swelling of
the larynx and skeletal paralysis affecting the ability to
breathe, circulatory shock and convulsions.
TARGET ORGAN INFORMATION
Kidneys. Liver. Blood.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Subcutaneous
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Vascular:Tumors. Gastrointestinal:Tumors.
Mouse
Route of Application: Skin
Exposure Time: 50W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Skin and
Appendages: Other: Tumors.
Rat
Route of Application: Subcutaneous
Exposure Time: 53W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
IARC CARCINOGEN LIST
Rating: Group 2A Group 2A
Species: Mouse/rat Mouse/rat
Route: Skin Subcutaneous Gavage Skin Subcutaneous Gavage
CHRONIC EXPOSURE - MUTAGEN
Human
1 MMOL/L
Cell Type: fibroblast
DNA damage
Human
1 MMOL/L
Cell Type: Other cell types
DNA damage
Human
50 UMOL/L
Cell Type: HeLa cell
Unscheduled DNA synthesis
Rat
120 UMOL/L
Cell Type: Other cell types
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Cytogenetic analysis
Mouse
393 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
8 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
1 UMOL/L
Cell Type: Embryo
Micronucleus test
Hamster
1600 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
100 UMOL/L
Cell Type: ovary
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 11 UG/KG
Route of Application: Oral
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 250 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (5D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mouse
Dose: 2500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
CMR CAT.: Carc. Cat.3
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1738
Class: 6.1
PG: II
Proper Shipping Name: Benzyl chloride
IMDG
UN#: 1738
Class: 6.1
PG: II
Subrisk: 8
Proper Shipping Name: Benzyl chloride
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1738
Class: 6.1
PG: II
Subrisk: 8
Proper Shipping Name: Benzyl chloride
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 602-037-00-3
NOTA: E
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 22 23 37/38 41 48/22
May cause cancer. Harmful if swallowed. Toxic by inhalation.
Irritating to respiratory system and skin. Risk of serious
damage to eyes. Harmful: danger of serious damage to health by
prolonged exposure if swallowed.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
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The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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