SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/JUN/2005
Date Updated: 02/MAY/2005
Version 1.9
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TRIFLUOROACETIC ANHYDRIDE,
REAGENTPLUS(TM), >=99%
Product Number 106232
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TRIFLUOROACETIC ANHYDRIDE 407-25-0 206-982-9 None
Formula C4F6O3
Molecular Weight 210.03 AMU
Synonyms Anhydrid kyseliny trifluoroctove (Czech) *
Bis(trifluoroacetic) anhydride *
Hexafluoroacetic anhydride * Perfluoroacetic
anhydride * Trifluoroacetic acid anhydride *
Trifluoroacetic anhydride * Trifluoroacetyl
anhydride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Reacts violently with water. Harmful by inhalation. Causes severe
burns. Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
SPECIAL RISKS
Specific Hazard(s): Water reactive material. Emits toxic fumes
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Incompatible Materials: Do not allow contact with water
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
ALDRICH - 106232 www.sigma-aldrich.com Page 2
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 39 - 40 癈
MP/MP Range -65 癈
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 324.676 mmHg 20 癈
SG/Density 1.511 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Do not allow water to enter container.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen fluoride.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AJ9800000
IRRITATION DATA
Skin
Rabbit
0.75 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
5 mg
ALDRICH - 106232 www.sigma-aldrich.com Page 3
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes severe burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3265
Class: 8
PG: I
Proper Shipping Name: Corrosive liquid, acidic,
organic, n.o.s.
IMDG
UN#: 3265
Class: 8
PG: I
Proper Shipping Name: CORROSIVE LIQUID, ACIDIC,
ORGANIC, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3265
Class: 8
PG: I
Proper Shipping Name: Corrosive liquid, acidic,
organic, n.o.s.
ALDRICH - 106232 www.sigma-aldrich.com Page 4
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 14 20 35 52/53
Reacts violently with water. Harmful by inhalation. Causes
severe burns. Harmful to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S-PHRASES: 26 36/37/39 43 45 61
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing, gloves, and eye/face protection. In case of fire,
never use water. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where
possible). Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 106232 www.sigma-aldrich.com Page 5
|