SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 04/17/2006
Date Updated: 01/26/2006
Version 1.4
Section 1 - Product and Company Information
Product Name CAPSAICIN, NATURAL
Product Number 360376
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
CAPSAICIN 404-86-4 No
Formula C18H27NO3
Synonyms Capsaicin * Capsaicine *
N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-n
onenamide *
trans-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-meth
yl-6-nonenamide *
(E)-8-Methyl-N-vanillyl-6-nonenamide *
trans-8-Methyl-N-vanillyl-6-nonenamide *
NCI-C56564 * 6-Nonenamide, 8-methyl-N-vanillyl-,
(E)- (8CI)
RTECS Number: RA8530000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Toxic (EU).
Toxic if swallowed. Irritating to respiratory system and skin.
Risk of serious damage to eyes. May cause sensitization by
inhalation and skin contact.
Sternutator. Lachrymator. Target organ(s): Nerves.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
235 癋 113 癈 Method: closed cup
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
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ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face particle respirator type N100 (US) or
type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a
full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 305.42 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 66 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 235 癋 113 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solvent: 50 mg/ml CHCl3 Clear
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
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Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Lachrymator. Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
SENSITIZATION
Sensitization: May cause allergic reaction.
TARGET ORGAN(S) OR SYSTEM(S)
Nerves.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
CONDITIONS AGGRAVATED BY EXPOSURE
Causes sneezing. Do not inhale.
TOXICITY DATA
Oral
mouse, male
118.8 mg/kg
LD50
Oral
mouse, female
97.4 mg/kg
LD50
Oral
rat, male
161.2 mg/kg
LD50
Oral
rat, female
148.1 mg/kg
LD50
Intraperitoneal
Rat
9500 UG/KG
LD50
Remarks: Behavioral:Muscle contraction or spasticity.
Behavioral:Excitement. Behavioral:Convulsions or effect on
seizure threshold.
Oral
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Mouse
47.2 mg/kg
LD50
Skin
Mouse
> 512 mg/kg
LD50
Intraperitoneal
Mouse
6500 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
Subcutaneous
Mouse
9000 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
Intravenous
Mouse
400 UG/KG
LD50
Intramuscular
Mouse
7800 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
Intratracheal
Mouse
1600 UG/KG
LD50
Remarks: Behavioral:Excitement. Behavioral:Convulsions or effect
on seizure threshold. Behavioral:Muscle contraction or
spasticity.
Rectal
Mouse
>218 MG/KG
LD50
Intraperitoneal
Rabbit
>50 MG/KG
LD50
Intraperitoneal
Guinea pig
1100 UG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Behavioral:Muscle contraction or
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spasticity.
Intraperitoneal
Hamster
>120 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Mouse
Route of Application: Oral
Dose: 3318 MG/KG
Exposure Time: 5W
Frequency: C
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Species: Mouse
Route: Intraperitoneal
Dose: 7500 UG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Intraperitoneal
Dose: 1800 UG/KG
Mutation test: DNA inhibition
Species: Mouse
Route: Intraperitoneal
Dose: 93120 UG/KG
Exposure Time: 32D
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 5 MG/L (+S9)
Cell Type: lung
Mutation test: Mutation in microorganisms
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
PIH: Not PIH
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IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 25-37/38-41-42/43
Risk Statements: Toxic if swallowed. Irritating to respiratory
system and skin. Risk of serious damage to eyes. May cause
sensitization by inhalation and skin contact.
S: 22-26-28-36/39-45
Safety Statements: Do not breathe dust. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice. After contact with skin, wash immediately with plenty of
soap-suds. Wear suitable protective clothing and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Toxic (EU).
Risk Statements: Toxic if swallowed. Irritating to respiratory
system and skin. Risk of serious damage to eyes. May cause
sensitization by inhalation and skin contact.
Safety Statements: Do not breathe dust. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice. After contact with skin, wash immediately with plenty of
soap-suds. Wear suitable protective clothing, gloves, and
eye/face protection. In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
US Statements: Sternutator. Lachrymator. Target organ(s): Nerves.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2006 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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