8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 1 ..................................................... PRODUCT IDENTIFICATION ........................................................................
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
SECTION 2 .................................. COMPOSITION, INFORMATION ON INGREDIENTS .....................................................
Synonyms TFAA; 2,2,2-Trifluoroacetic anhydride; Bis(trifluoroacetic) anhydride; Hexafluoroacetic anhydride;
Perfluoroacetic anhydride; Trifluoroacetic acid anhydride; Trifluoroacetyl anhydride
CAS #: 407-25-0 MF: C4F6O3
Ingredients Concentration (%/wt)
Trifluoroacetic Anhydride (407-25-0) ....................................................................................... NLT 99.0 %
Manufacturing Impurities......................................................................................................... NMT 1.0 %
SECTION 3 ..................................................... HAZARDS IDENTIFICATION ........................................................................
Precautionary Statements See Sections 8 and 11 for further details.
Corrosive. Causes burns.
........................................................ Emergency Overview .......................................................
NFPA Ratings (Scale 0-4); Health = 3; Fire = 1; Reactivity = 2; W
Liquid: clear, colorless. Odor: strong pungent
Corrosive liquid and vapor--TFAA can decompose on contact with water to produce
hydrofluoric acid, that in contact with metals can generate flammable/explosive
hydrogen gas.
Contact with water produces a large evolution of heat and possible violent reaction.
Sufficient dilution of water may reduce the acidity of the solution.
The properties of this material have not been fully investigated. Use due caution in
handling and use of this material.
Corrosive--Cause burns to all body tissues. Permanent eye damage possible. May be
fatal of toxic if swallowed or inhaled.
Emits toxic fumes under fire conditions--potential chemical or thermal decomposition products:
carbon oxides, hydrogen fluoride
Standard chemical handling precautions: Avoid ingestion or breathing mists. Avoid contact
with eyes, skin, and clothing. Wash thoroughly after handling.
Target organs: mucous membranes, skin, eyes, respiratory system, lungs, teeth
See Sections 4, 5, 6, 8, 9, and 10.
.....................................................................................................................................................
Other Hazard Information
This compound has not fully been tested for toxicological, irritation, or similar tendencies.
Primary Route(s) of Entry: Inhalation, Ingestion, Eye, Skin
Eye: Corrosive--Can cause burns. May cause severe irritation, itching, tearing, redness, corneal
inflammation, blurred vision, and lens damage. Permanent eye damage possible.
Skin: Corrosive--Can cause burns with redness and possible blistering. May cause severe irritation
with itchiness and dryness, cracking and dermatitis due to the loss of natural skin oils.
Inhalation: Corrosive--Causes burns or severe irritation to mucous membranes, respiratory tract, nose,
throat, and lung damage. May be harmful or fatal if inhaled in large quantities due to spasm,
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 1 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema
(fluid retention/swelling) . Prolonged/repeated inhalation may cause tooth decay.
Ingestion: Can cause burns. May be toxic or fatal if ingested due to mucous membrane corrosion and other
tissue in the esophagus and GI tract. Symptoms include sore throat, pain, nausea, vomiting, and
diarrhea.
Acute: See above route.
Chronic: See above route.
Symptoms: See specific route above.
Pre-existing conditions that may be aggravated: skin, eye, respiratory, GI tract
See Section 11 for additional toxicological data.
SECTION 4 ......................................................... FIRST AID MEASURES ............................................................................
Eye contact: Immediately flush eyes with copious amounts of water or eyewash solution for at least 15
minutes; lift eyelids occasionally. If irritation persists, consult physician.
Skin contact: Immediately remove contaminated clothing and shoes, then wash skin with soap and copious
amounts of water. If irritation persists, consult physician.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration and keep person warm and at
rest. If breathing is difficult, give oxygen; consult physician.
Ingestion: Wash out mouth with water provided person is conscious; give large amounts of water or milk.
Repeat if vomiting occurs. Ingested corrosive should be diluted approximately 100 times to
render it harmless to tissues (Dreisbach & Robertson; Handbook of Poisoning; 12th Ed.);
consult physician; DO NOT induce vomiting without first consulting physician. If vomiting
occurs, keep head lower than hips to help prevent aspiration. Maintain airway and respiration.
Treat symptomatically and supportively.
Wash contaminated clothing before reuse. Discard contaminated footware.
Physician note: Symptomatic and supportive care. No specific antidote, but treatment may be similar to that of
hydrofluoric acid burns. Treatment based on physician judgment in response to reactions of
the patient.
SECTION 5 ..................................................... FIRE FIGHTING MEASURES ........................................................................
Flash Point: NE Method: NE Autoignition: NE
OSHA Flammability Class: NA Explosion Limits: upper: NE
NFPA: See Section 3 Hazards Identification Emergency Overview above. lower: NE
Extinguishing Media
Water spray, carbon dioxide, dry chemical powder, or appropriate foam. Do NOT use straight water streams.
Special Fire Fighting Procedures
Self-contained breathing apparatus (SCBA) and protective clothing to prevent contact with skin and eyes should
be worn in fighting large fires involving chemicals.
Standard Fire and Explosion Hazards
Avoid inhalation of material or combustion by-products.
Unusual Fire and Explosion Hazards
Corrosive liquid and vapor--TFAA can decompose on contact with water to produce hydrofluoric acid, that in
contact with metals can generate flammable/explosive hydrogen gas.
Contact with water produces a large evolution of heat and possible violent reaction. Sufficient dilution of water
may reduce the acidity of the solution.
Containers may build pressure or rupture when heated.
Water spray may be used to cool fire-exposed containers. Emits toxic fumes under fire conditions.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 2 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Hazardous Combustion or Decomposition Products
carbon oxides, hydrogen fluoride
SECTION 6 ............................................. ACCIDENTAL RELEASE MEASURES ................................................................
Eliminate all ignition sources. Use spark proof tools.
Evacuate unnecessary people from area. Isolate spilled material.
Ventilate area.
Wear protective clothing to prevent contact with skin and eyes (lab coat, gloves, and safety glasses).
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation of mists.
Contain and recover material when possible.
Use chemically compatible spill pillows, or similar adsorbent material.
Sweep up, seal in appropriate hazardous waste container, and hold for proper waste disposal.
(If possible to do so safely, neutralize waste to pH 6-9 prior to disposal.)
Avoid raising contaminated dust.
Wash spill site after material pickup is complete.
Standard chemical precautions: Keep out of water supplies and sewers.
SECTION 7 ..................................................... HANDLING AND STORAGE.........................................................................
General Handling Measures
See Section 8 Below.
General Storage Measures
Store in a cool, dry place with adequate ventilation, in a storage area suitable for corrosives.
Special Storage Instructions
Do not store in metal containers.
Empty containers retain product residue, (liquid/vapor), and can be dangerous.
Special Handling Instructions
Use appropriate precautions for handling corrosive liquids.
Wash thoroughly after handling.
Since material is very corrosive to body tissues, immediately remove contaminated clothing.
SECTION 8 ................................. EXPOSURE CONTROLS, PERSONAL PROTECTION ....................................................
Airborne Exposure Limits TWA (8H) STEL/VPEL Ceiling Limit Ceiling (skin)
3 3 3
mg/m3
ppm mg/m ppm mg/m ppm mg/m ppm
Trifluoroacetic OSHA PEL NE NE NE NE NE NE NE NE
Anhydride
407-25-0 ACGIH - TLV NE NE NE NE NE NE NE NE
Hydrogen OSHA PEL 3 2 6 NE NE NE NE NE
Fluoride* ACGIH - TLV NE NE NE NE 3 NE NE NE
NE = Not established; * Hydrogen fluoride may be formed on contact with humid air or water.
Special/Other Control Measures
Odor threshold: NE
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 3 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Personal Protective Equipment (PPE)
OSHA/ANSI approved chemical safety eyewear or goggles
Compatible chemical-resistant gloves: Rubber (e.g., natural rubber, neoprene, nitrile, or equivalent), Silver
Shield? Viton? or 4H?br>
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation.
Protective Clothing (e.g., lab coat)
Other Standard Safety Equipment and Engineering Preventive Measures
Safety shower and eye wash
Mechanical exhaust required. Hood recommended. Use adequate general and/or local exhaust ventilation to
keep airborne concentrations below the permissible exposure limits.
General Precautions and Handling Measures
Avoid ingestion, inhalation and contact with eyes, skin, and clothing.
Avoid prolonged or repeated exposure. Wash thoroughly after handling.
Material is very destructive to body tissues.
Wash contaminated clothing before reuse. Discard contaminated footware.
SECTION 9 ......................................... PHYSICAL AND CHEMICAL PROPERTIES ............................................................
Chemical Family: Halogenated, organic acid anhydride Use: Analytical Derivatization Acylation Reagent for GC
Appearance, Odor, and Other Properties
Appearance: clear, colorless liquid Odor: pungent, strong
Freeze/MP: -65癈 (-85癋) Water Reactive: yes
bp (1atm): 39.5-40癈 (103癋) Water Solubility: soluble/decomposes
FW: 210.03 Specific Gravity (H20 = 1.0): 1.487
VP (mmHg): 40 mm (21.1癈) Vapor Density (air=1): NE
% Volatiles: 100% Evap. Rate (BuAc = 1.0): NE
Refractive Index (nD20):
pH: NE <1.300
Soluble in Organic Solvents: NE
SECTION 10 .................................................. STABILITY AND REACTIVITY .......................................................................
Stability
Stable
Incompatibilities
Amines
Metals
Strong acids and bases
Strong oxidizers
Strong reducing agents
Water--possible violent evolution of heat on contact. May decompose to HF, which in contact with metals may
produce flammable/explosive hydrogen gas.
Precautions
Avoid incompatibilities.
Protect from heat, flames, sparks, and ignition sources.
Keep out of water supplies and sewers.
Hazardous Combustion or Decomposition Products
carbon oxides, hydrogen fluoride
Hazardous Polymerization
None
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 4 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 11 .............................................. TOXICOLOGICAL INFORMATION....................................................................
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
RTECS # CAS #
AJ9800000 Trifluoroacetic Anhydride 407-25-0 Only selected Registry of Toxic Effects of Chemical
MW7875000 Hydrogen Fluoride 7664-39-3 Substances data (RTECS) is presented here.
See actual entry in RTECS for complete information.
Irritation Data eye skin
Trifluoroacetic Anhydride eye rbt 5mg/24H sev Irr skn 750 ug/24H sev
Hydrogen Fluoride eye hmn 50 mg sev NDA
NDA = No data available
Toxicity Data oral inhalation dermal
Trifluoroacetic NDA NDA NDA
Anhydride
Hydrogen Fluoride orl man TDLo 143mg/kg ihl man TCLo 100 mg/m3/1M skn mus LDL0 500mg/kg
ihl hmn LCLo 50ppm/30M
ihl rat LC50 1276ppm/1H
Carcinogenicity OSHA IARC NTP ACGIH NIOSH Notes
Trifluoroacetic NL NL NL NL NL None
Anhydride
Hydrogen Fluoride NL NL NL NL NL IARC Group 3--Not classifiable as a
carcinogen
NL = Not Listed as a carcinogen;
Teratogenicity and Reproductive Effects
Laboratory studies reported in RTECS indicate that hydrofluoric acid may cause adverse fetal effects and
reproductive effects.
Neurotoxicity
No data available.
Mutagenicity
RTECS reports mutation data on hydrogen fluoride.
Miscellaneous
No data available.
Acute and Chronic Effects
Section 3 Hazards Identification above.
SECTION 12 ................................................. ECOLOGICAL INFORMATION.......................................................................
Environmental Fate and Ecotoxicity Data
Trifluoroacetic anhydride: No data available.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 5 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Standard Chemical Precautions
Keep out of air, water, and soil
SECTION 13 ................................................. DISPOSAL CONSIDERATIONS ......................................................................
That which cannot be recovered or recycled, should be disposed of in accordance with all applicable Federal, State, and
local environmental regulations.
RCRA waste code(s): D002 RCRA Hazard Class (40CFR 261): Corrosive
SECTION 14 .................................................. TRANSPORT INFORMATION........................................................................
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
U. S. Department of Transportation (49CFR171.101)
Shipping Name: Corrosive liquid, n.o.s. (trifluoroacetic acid anhydride)
Hazard Class or Division: 8, Subsidiary Class: none
ID Number: UN1760
Packing Group: I
Labeling: Corrosive Liquid
SECTION 15 ................................................. REGULATORY INFORMATION ......................................................................
Reviews, Standards, and Regulations
.................................................................................. ....... Trifluoroacetic Anhydride ..... ......................
CAS number ............................................................. ....................407-25-0.................. ......................
TSCA:.............................................................................. ..........................Y........................ ......................
This compound is sold strictly for FDA or research and development use.
EINECS: .......................................................................... ..........................Y........................ ......................
Number ............................................................................. ......................206-982-9 ................... ........................
CERCLA [Section 103 (40 CFR 302.4)]: ....................... .........................NL....................... ......................
RQ (lbs)............................................................................. ........................... NA ......................... ........................
RCRA Waste Code ........................................................... ........................... NA ......................... ........................
OSHA Process Safety [29 CFR 1910.119]: ................... .........................NL....................... ......................
TQ (lbs) ............................................................................. ........................... NA ......................... ........................
Clean Air Act
[Section 112r (40 CFR 68)]: .............................................. ........................... NL ......................... ........................
TQ (lbs) ........................................................................ ........................... NA ......................... ........................
Contains Ozone Depleters (Class I or Class II)................. ............................ N .......................... ........................
SARA Title III Notification [40 CFR 302.4]:
Section 302/304 (EHS) Ingredient
[40 CFR 355.3].................................................................. ........................... NL ......................... ........................
TPQ (lbs....................................................................... ........................... NA ......................... ........................
RQ (lbs)........................................................................ ........................... NA ......................... ........................
Section 313 Ingredient [40 CFR 372.65] ........................... ........................... NL ......................... ........................
State Lists: ...................................................................... .........................NL....................... ......................
States................................................................................ ........................... NL ......................... ........................
.......................................................................................... .............................. ........................... ........................
On CA 65 Significant Risk Level ....................................... ........................... NL ......................... ........................
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 6 of 7
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: Trifluoroacetic Anhydride
Code: 270841, 270843
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Hazard Classes
Sara Acute Chronic Fire Pressure Reactivity
Title III Y N N N Y
Health Flammability Reactivity Special Hazards
NFPA 3 1 2 W
HMIS 3 1 2 None
Risk Phrases:
Caution: The properties of this material have not been fully investigated.
Corrosive
R20/21/22............ Harmful by inhalation, in contact with skin and if swallowed
R34...................... Causes burns.
R36/37/38............ Irritating to eyes (severely), respiratory system, and skin.
R40...................... Possible risk of irreversible effects.
R41...................... Risk of serious damage to eyes.
Safety Phrases:
S23/24/25 ............ Do not breath vapors. Avoid contact with skin and eyes
S26/28 ................. In case of contact with eyes or skin, rinse immediately with plenty of water and seek medical
advice.
S27 ...................... Take off immediately all contaminated clothing.
S36/37/39 ............ Wear suitable protective clothing, gloves, and eye/face protection.
S44 ...................... If you feel unwell, seek medical advice immediately (show the label where possible.)
SECTION 16 ........................................................OTHER INFORMATION .............................................................................
Miscellaneous
The health and toxicological hazards of this compound have not been fully investigated; therefore, this substance
must be handled only by, or under close supervision of those qualified in the handling and use of potentially
hazardous substances.
This MSDS was revised as follows:
This is a new MSDS format. Consider all sections to contain new information.
Disclaimer
The above information is believed to be correct, but does not purport to be all-inclusive and shall be used only as a guide.
Regis Technologies, Inc., does not guarantee said information is accurate or complete, nor shall any of this information
constitute a warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the
fitness of the goods for a particular purpose. Adjustment may be required to conform to the actual conditions of usage. Regis
Technologies, Inc. shall not be held liable for any damage resulting from handling or from contact with the above product, nor
for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
Approved of by: MBF This is the last page of this MSDS.
Reviewed and re-approved of with minor changes to the abbreviations in the footer and format.
by: Jon Pilli 07/24/2008
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 270841c2 Effective Date: 07/24/2008 Version #: 3.2 Page 7 of 7
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