SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 05/24/2004
Date Updated: 03/06/2004
Version 1.5
Section 1 - Product and Company Information
Product Name M-CRESOL, 97%
Product Number C85735
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
M-CRESOL 108-39-4 Yes
Formula C7H8O
Synonyms 3-Cresol * m-Cresol (ACGIH:OSHA) * m-Cresole *
m-Cresylic acid * 1-Hydroxy-3-methylbenzene *
m-Hydroxytoluene * 3-Hydroxytoluene * m-Kresol *
m-Methylphenol * 3-Methylphenol * m-Oxytoluene *
Phenol, 3-methyl- (9CI) * RCRA waste number U052
* m-Toluol
RTECS Number: GO6125000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
Toxic in contact with skin and if swallowed. Causes burns.
Readily absorbed through skin. Combustible. Target organ(s):
Central nervous system. Lungs.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 2
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 2
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
186.8 癋 86 癈 Method: closed cup
EXPLOSION LIMITS
Lower: 1.06 % Upper: 1.35 %
AUTOIGNITION TEMP
558 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Keep away from heat and open
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flame. Store in a cool dry place.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH TWA 5 PPM
Remarks: Skin
USA MSHA Standard-air TWA 5 PPM (22 MG/M3)
USA OSHA. PEL 8H TWA 5 PPM (22 MG/M3) (SKIN)
New Zealand OEL
Remarks: check ACGIH TLV
USA NIOSH TWA 2.3 PPM
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
Molecular Weight 108.14 AMU
pH N/A
BP/BP Range 200 - 203 癈
MP/MP Range 8 - 10 癈
Freezing Point N/A
Vapor Pressure < 1 mmHg 20 癈
Vapor Density 3.72 g/l
Saturated Vapor Conc. N/A
SG/Density 1.034 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity 12.9 Pas 25 癈
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 186.8 癋 86 癈 Method: closed cup
Explosion Limits Lower: 1.06 %
Upper: 1.35 %
Flammability N/A
Autoignition Temp 558 癈
Refractive Index 1.542
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Optical Rotation N/A
Miscellaneous Data N/A
Solubility Other Solvents: MISCIBLE IN ALCOHOL, ETHER
SOLUBLE IN ACETONE, ETHANOL,
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Sensitive to moisture.
Materials to Avoid: Oxidizing agents, Bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Toxic if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Central nervous system. Lungs. Liver. Kidneys. Eyes.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: Damage to the eyes. Damage to the
kidneys. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
TOXICITY DATA
Oral
Rat
242 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
Gastrointestinal:Peritonitis.
Inhalation
Rat
> 710 mg/m3
LC50
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Skin
Rat
1100 mg/kg
LD50
Oral
Mouse
828 mg/kg
LD50
Intraperitoneal
Mouse
168 MG/KG
LD50
Skin
Rabbit
2050 mg/kg
LD50
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Convulsions or effect on
seizure threshold. Gastrointestinal:Changes in structure or
function of salivary glands.
IRRITATION DATA
Skin
Rabbit
517 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
103 mg
Remarks: Severe irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Species: Mouse
Route of Application: Skin
Dose: 2280 MG/KG
Exposure Time: 20W
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
CHRONIC EXPOSURE - TERATOGEN
Species: Rabbit
Dose: 134 GM/KG
Route of Application: Subcutaneous
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 10 UMOL/L
Exposure Time: 4H
Cell Type: HeLa cell
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Mutation test: DNA inhibition
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Time: 24 h
Value: 110 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 25 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 17 - 19 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 8.9 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Cresols
UN#: 2076
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Cresols, liquid (o-, m-, p-)
IATA UN Number: 2076
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 24/25 34
Risk Statements: Toxic in contact with skin and if swallowed.
Causes burns.
S: 36/37/39 45
Safety Statements: Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
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US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic.
Risk Statements: Toxic in contact with skin and if swallowed.
Causes burns.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US Statements: Readily absorbed through skin. Combustible.
Target organ(s): Central nervous system. Lungs.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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