REPRODUCTIVE HAZARDS The following is to be used only as a general guideline. Please refer to your Material Safety Data Sheets (MSDS) for specific information. CAS Number CHEMICALS KNOWN TO CAUSE REPRODUCTIVE TOXICITY Developmental Toxicity Acetohydroxamic acid 546-88-3 Actinomycin D 50-76-0 All-trans retinoic acid 302-79-4 Alprazolam 28981-97-7 Amikacin sulfate 39831-55-5 Aminoglutethimide 125-84-8 Aminoglycosides various Aminopterin 54-62-6 Angiotensin converting enzyme (ACE) inhibitors various Anisindione 117-37-3 Aspirin (NOTE: It is especially important not to use aspirin during the last three months of 50-78-2 pregnancy) Barbiturates various Benomyl 17804-35-2 Benzphetamine hydrochloride 5411-22-3 Benzodiazepines various Bischloroethyl nitrosourea (BCNU) (Carmustine) 1540-93-8 Bromoxynil 1689-84-5 Butabarbital sodium 143-81-7 1,4-Butanediol dimethylsulfonate (Busulfan) 55-98-1 Carbon disulfide 75-15-0 Carbon monoxide 630-08-0 Carboplatin 41575-94-4 Chenodiol 474-25-9 Chlorcyclizine hydrochloride 1620-21-9 Chlorambucil 305-03-3 Chlordecone (Kepone) 143-50-0 Chlordiazepoxide 58-25-3 Chlordiazepoxide hydrochloride 438-41-5 1-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) (Lomustine) 13010-47-4 Clomiphene citrate 50-41-9 Clorazepate dipotassium 57109-90-7 Cocaine 50-36-2 Colchicine 64-86-8 Conjugated estrogens n/a Cyanazine 21725-46-2 Cycloheximide 66-81-9 Cyclophosphamide (anhydrous) 50-18-0 Cyclophosphamide (hydrated) 6055-19-2 Cyhexatin 13121-70-5 Cytarabine 147-94-4 Danazol 17230-88-5 Daunorubicin hydrochloride 23541-50-6 Demeclocycline hydrochloride (internal use) 64-73-3 Diazepam 439-14-5 Dicumarol 66-76-2 Diethylstilbestrol (DES) 56-53-1 Dinocap 39300-45-3 Dinoseb 88-85-7 Diphenylhydantoin (Phenytoin) 57-41-0 Doxycycline (internal use) 564-25-0 Doxycycline calcium (internal use) 94088-85-4 Doxycycline hyclate (internal use) 24390-14-5 Doxycycline monohydrate (internal use) 17086-28-1 Ergotamine tartrate 379-79-3 Ethyl alcohol in alcoholic beverages n/a Ethylene glycol monoethyl ether 110-80-5 Ethylene glycol monomethyl ether 109-86-4 Ethylene glycol monoethyl ether acetate 111-15-9 Ethylene glycol monomethyl ether acetate 110-49-6 Ethylene thiourea 96-45-7 Etoposide 33419-42-0 Etretinate 54350-48-0 Fluorouracil 51-21-8 Fluoxymesterone 76-43-7 Flurazepam hydrochloride 1172-18-5 Flutamide 13311-84-7 Halazepam 23092-17-3 Hexachlorobenzene 118-74-1 Ifosfamide 3778-73-2 Iodine-131 10043-66-0 Isotretinoin 4759-48-2 Lead 7439-92-1 Lithium carbonate 554-13-2 Lithium citrate 919-16-4 Lorazepam 846-49-1 Lovastatin 75330-75-5 Medroxyprogesterone acetate 71-58-9 Megestrol acetate 595-33-5 Melphalan 148-82-3 Menotropins 9002-68-0 Meprobamate 57-53-4 Mercaptopurine 6112-76-1 Mercury and mercury compounds various Methacycline hydrochloride 3963-95-9 Methimazole 60-56-0 Methotrexate 59-05-2 Methotrexate sodium 15475-56-6 Methyl bromide as a structural fumigant 74-83-9 Methyl mercury (dimethyl mercury) 593-74-8 Methyltestosterone 58-18-4 Midazolam hydrochloride 59467-96-8 Minocycline hydrochloride (internal use) 13614-98-7 Misoprostol 59122-46-2 Mitoxantrone hydrochloride 70476-82-3 Nafarelin acetate 86220-42-0 Neomycin sulfate (internal use) 1405-10-3 Netilmicin sulfate 56391-57-2 Nicotine 54-11-5 Nitrogen mustard (Mechlorethamine) 51-75-2 Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) 55-86-7 Norethisterone (Norethindrone) 68-22-4 Norethisterone acetate (Norethindrone acetate) 51-98-9 Norethisterone (Norethindrone)/Ethinyl estradiol 68-22-4/57-63-6 Norethisterone (Norethindrone)/Mestranol 68-22-4/72-33-3 Norgestrel 6533-00-2 Oxazepam 604-75-1 Oxytetracycline (internal use) 79-57-2 Oxytetracycline hydrochloride(internal use) 2058-46-0 Paramethadione 115-67-3 Penicillamine 52-67-5 Pentobarbital sodium 63-98-9 Phenprocoumon 435-97-2 Pipobroman 54-91-1 Plicamycin 18378-89-7 Polybrominated biphenyls 922-66-0 Polychlorinated biphenyls various Procarbazine hydrochloride 366-70-1 Propylthiouracil 51-52-5 Ribavirin 36791045 Secobarbital sodium 309-43-3 Streptomycin sulfate 3810-74-0 Tamoxifen citrate 54965-24-1 Temazepam 846-50-4 Testosterone cypionate 58-20-8 Testosterone enanthate 315-37-7 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) 1746-01-6 Tetracyclines (internal use) various Tetracycline (internal use) 60-54-8 Tetracycline hydrochloride (internal use) 64-75-5 Thalidomide 50-35-1 Thioguanine 154-42-7 Tobacco smoke (primary) n/a Tobramycin sulfate 108-88-3 Triazolam 28911-01-5 Trilostane 13647-35-3 Trimethadione 127-48-0 Uracil mustard 66-75-1 Urethane 51-79-6 Urofollitropin 26995-91-5 Valproate (Valproic acid) 99-66-1 Vinblastine sulfate 143-67-9 Vincristine sulfate 2068-78-2 Warfarin 81-81-2 Female Reproductive Toxicity Aminopterin 54-62-6 Anabolic steroids n/a Aspirin(NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause 50-78-2 problems in the unborn child or complications during delivery.) Carbon disulfide 75-15-0 Cocaine 50-36-2 Cyclophosphamide (anhydrous) 50-18-0 Cyclophosphamide (hydrated) 6055-19-2 Ethylene oxide 75-21-8 Lead Tobacco smoke (primary) n/a Uracil mustard 66-75-1 Male Reproductive Toxicity Anabolic steroids n/a Benomyl 17804-35-2 Carbon disulfide 75-15-0 Colchicine 64-86-8 Cyclophosphamide (anhydrous) 50-18-0 1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 m-Dinitrobenzene 99-65-0 o-Dinitrobenzene 528-29-0 p-Dinitrobenzene 100-25-4 Dinoseb 88-85-7 Ethylene glycol monoethyl ether 110-80-5 Ethylene glycol monomethyl ether 109-86-4 Ethylene glycol monoethyl ether acetate 111-15-9 Ethylene glycol monomethyl ether acetate 110-49-6 Hexamethylphosphoramide 680-31-9 Lead 7439-92-1 Nitrofurantoin 67-20-9 Tobacco smoke (primary) n/a Uracil mustard 66-75-1 Updated 1-29-02 Division of Laboratory Resources and Safety Centre College 600 W Walnut St Danville KY 40422