SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 04/19/2006
Date Updated: 02/04/2006
Version 1.3
Section 1 - Product and Company Information
Product Name 4-NITROBENZYL CHLORIDE, 99%
Product Number 140112
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
4-NITROBENZYL CHLORIDE 100-14-1 Yes
Formula C7H6ClNO2
Synonyms Benzene, 1-(chloromethyl)-4-nitro- (9CI) *
p-(Chloromethyl)nitrobenzene *
1-(Chloromethyl)-4-nitrobenzene *
4-(Chloromethyl)nitrobenzene *
alpha-Chloro-p-nitrotoluene * p-Nitrobenzyl
chloride
RTECS Number: XS9093000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Corrosive.
Causes burns. Harmful by inhalation, in contact with skin and if
swallowed.
Lachrymator.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
Contamination of the eyes should be treated by immediate and
prolonged irrigation with copious amounts of water. Assure
adequate flushing of the eyes by separating the eyelids with
fingers.
INFORMATION FOR PHYSICIAN
Contamination of the eyes should be treated by immediate and
prolonged irrigation with copious amounts of water.
Section 5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
EXPOSURE HAZARD(S)
Material: Corrosive. Lachrymator. Harmful solid.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Section 8 - Exposure Controls / PPE
ALDRICH - 140112 www.sigma-aldrich.com Page 2
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand: Wear heavy rubber gloves.
Eye: Chemical safety goggles.
Other: Faceshield (8-inch minimum).
GENERAL HYGIENE MEASURES
Discard contaminated clothing and shoes.
Section 9 - Physical/Chemical Properties
Appearance Color: Faintly yellow
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 171.58 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 70 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions to Avoid: Moisture.
Materials to Avoid: Alcohols, Bases, Amines, Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
ALDRICH - 140112 www.sigma-aldrich.com Page 3
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas, Nitrogen oxides.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. Causes burns.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin. Depending
on the intensity and duration of exposure, effects may vary from
mild irritation to severe destruction of tissue. Symptoms of
exposure may include burning sensation, coughing, wheezing,
laryngitis, shortness of breath, headache, nausea, and vomiting.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
TOXICITY DATA
Oral
Rat
1809 mg/kg
LD50
CHRONIC EXPOSURE - MUTAGEN
Species: Hamster
Dose: 100 UMOL/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Corrosive solid, acidic,
organic, n.o.s.
UN#: 3261
Class: 8
Packing Group: Packing Group II
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Corrosive solid, acidic,
organic, n.o.s.
IATA UN Number: 3261
Hazard Class: 8
Packing Group: II
ALDRICH - 140112 www.sigma-aldrich.com Page 4
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 22-34
Risk Statements: Harmful if swallowed. Causes burns.
S: 26-36/37/39-45
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Corrosive.
Risk Statements: Causes burns. Harmful by inhalation, in contact
with skin and if swallowed.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Take
off immediately all contaminated clothing. Wear suitable
protective clothing, gloves, and eye/face protection. Keep
container tightly closed in a cool well-ventilated place.
US Statements: Lachrymator.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: Yes
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2006 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
ALDRICH - 140112 www.sigma-aldrich.com Page 5
|