MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 1 of 8
MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
AMBION, INC AMBION, INC
2130 WOODWARD ST. LTD HUNTINGDON
AUSTIN, TX 78744 CAMBIDGESHIRE, UK PE29 6XY
(512) 651-0200 (USA) +44 1480 373 020 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
WEB ADDRESS: www.ambion.com (INTERNATIONAL)
MAIL: techserv@ambion.com MAIL: eurotech@ambion.com
SUBSTANCE: 25X RT-PCR ENZYME MIX
TRADE NAMES/SYNONYMS:
US MSDS P/N 4377787; P/N 1005鈥? P/N AM1005; P/N 2737G; P/N 1014; P/N 1012; P/N AM1012; P/N
AM1014; P/N AM1012; P/N AM1010; AgPath-ID鈩? BVDV DETECTION KIT; AgPath-ID鈩? AIV-MATRIX
GENE DETECTION KIT; AgPath-ID鈩? ALV DETECTION KIT; AgPath-ID鈩? One-Step RT-PCR
Detection Kit; 00231997
PRODUCT USE: For Research Use Only. Not for use in diagnostic procedures.
CREATION DATE: Jul 10 2006
REVISION DATE: Dec 13 2006
2. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: TRADE SECRET 00232112
CAS NUMBER: Not assigned.
PERCENTAGE: 30-60
COMPONENT: TRADE SECRET
CAS NUMBER: Not assigned.
PERCENTAGE: 30-60
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 2 of 8
3. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=1 FIRE=1 REACTIVITY=0
EMERGENCY OVERVIEW:
PHYSICAL FORM: liquid
MAJOR HEALTH HAZARDS: No significant target effects reported.
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, difficulty breathing
LONG TERM EXPOSURE: no information on significant adverse effects
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation
LONG TERM EXPOSURE: irritation
EYE CONTACT:
SHORT TERM EXPOSURE: irritation
LONG TERM EXPOSURE: no information on significant adverse effects
INGESTION:
SHORT TERM EXPOSURE: fever, nausea, vomiting, diarrhea, headache, dizziness,
sleep disturbances, blood disorders, kidney damage, paralysis, reproductive
effects, convulsions
LONG TERM EXPOSURE: no information on significant adverse effects
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give
artificial respiration if not breathing. Get immediate medical attention.
SKIN CONTACT: Wash skin with soap and water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention, if needed.
Thoroughly clean and dry contaminated clothing and shoes before reuse.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get
immediate medical attention.
INGESTION: If a large amount is swallowed, get medical attention.
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 3 of 8
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Slight fire hazard.
EXTINGUISHING MEDIA: carbon dioxide, regular dry chemical, regular foam, water
FIRE FIGHTING: Move container from fire area if it can be done without risk.
Avoid inhalation of material or combustion by-products. Stay upwind and keep
out of low areas.
FLASH POINT: not flammable
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition products or combustion: acrolein, oxides of carbon
6. ACCIDENTAL RELEASE MEASURES
WATER RELEASE:
Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986
(Proposition 65). Keep out of water supplies and sewers.
OCCUPATIONAL RELEASE:
Stop leak if possible without personal risk. Small spills: Absorb with sand or
other non-combustible material. Collect spilled material in appropriate
container for disposal. Notify Local Emergency Planning Committee and State
Emergency Response Commission for release greater than or equal to RQ (U.S.
SARA Section 304). If release occurs in the U.S. and is reportable under
CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA)
or (202)426-2675 (USA).
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and
standards. See original container for storage recommendations. Keep separated
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 4 of 8
from incompatible substances.
HANDLING: Subject to handling regulations: U.S. OSHA 29 CFR 1910.119.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
TRADE SECRET 00232112:
5 mg/m3 OSHA TWA (respirable dust fraction)
15 mg/m3 OSHA TWA (total dust)
10 mg/m3 OSHA TWA (total particulate) (vacated by 58 FR 35338, June 30,
1993)
10 mg/m3 ACGIH TWA
VENTILATION: Provide local exhaust ventilation system. Ensure compliance with
applicable exposure limits.
EYE PROTECTION: Wear splash resistant safety goggles. Provide an emergency eye
wash fountain and quick drench shower in the immediate work area.
CLOTHING: Wear appropriate chemical resistant clothing.
GLOVES: Wear appropriate chemical resistant gloves.
RESPIRATOR: Under conditions of frequent use or heavy exposure, respiratory
protection may be needed. Respiratory protection is ranked in order from
minimum to maximum. Consider warning properties before use.
Any chemical cartridge respirator with organic vapor cartridge(s).
Any chemical cartridge respirator with a full facepiece and organic vapor
cartridge(s).
Any air-purifying respirator with a full facepiece and an organic vapor
canister.
For Unknown Concentrations or Immediately Dangerous to Life or Health -
Any supplied-air respirator with full facepiece and operated in a
pressure-demand or other positive-pressure mode in combination with a
separate escape supply.
Any self-contained breathing apparatus with a full facepiece.
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 5 of 8
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
ODOR: Not available
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: Not available
PH: 7.5
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition.
Avoid contact with incompatible materials.
INCOMPATIBILITIES: oxidizing materials, acids, bases, metal oxides, peroxides,
reducing agents
HAZARDOUS DECOMPOSITION:
Thermal decomposition products or combustion: acrolein, oxides of carbon
POLYMERIZATION: Will not polymerize.
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 6 of 8
11. TOXICOLOGICAL INFORMATION
TRADE SECRET 00232112:
IRRITATION DATA:
500 mg/24 hour(s) skin-rabbit mild; 126 mg eyes-rabbit mild; 500 mg/24
hour(s) eyes-rabbit mild
TOXICITY DATA:
>570 mg/m3/1 hour(s) inhalation-rat LC50; >10 gm/kg skin-rabbit LD50; 12600
mg/kg oral-rat LD50
ACUTE TOXICITY LEVEL:
Slightly Toxic: ingestion
Additional toxicological data is available on the component(s) of this product. Please call 650-638-5635
or contact MSDS_Inquiry_CCRM@appliedbiosystems.com for more information.
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: No classification assigned.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: No classification assigned.
LAND TRANSPORT ADR: No classification assigned.
LAND TRANSPORT RID: No classification assigned.
AIR TRANSPORT IATA: No classification assigned.
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 7 of 8
AIR TRANSPORT ICAO: No classification assigned.
MARITIME TRANSPORT IMDG: No classification assigned.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.30):
Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.40):
Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370.21):
ACUTE: No
CHRONIC: No
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated.
OSHA PROCESS SAFETY (29CFR1910.119):
ETHYLENE OXIDE: 5000 LBS TQ
STATE REGULATIONS:
California Proposition 65:
Known to the state of California to cause the following:
ETHYLENE OXIDE
Cancer (Jul 01, 1987)
Female reproductive toxicity (Feb 27, 1987)
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: This product has been classified in accordance with
the hazard criteria of the CPR and the MSDS contains all of the
information required by the CPR.
MSDS PART NUMBER: 4377787 US
OHS PART NUMBER: 00231997
Revision number : D
Page 8 of 8
NATIONAL INVENTORY STATUS:
U.S. INVENTORY (TSCA): Not listed on inventory. For purposes of 40 CFR
720.36, this product is for Research and Development (R&D) Use Only.
TSCA 12(b) EXPORT NOTIFICATION: Not listed.
16. OTHER INFORMATION
Copyright 1984-2006 MDL Information Systems, Inc. All rights reserved.
850 Lincoln Centre Drive
Foster City, CA 94404
U.S.A.
T 650.570.6667
F 650.572.2743
www.appliedbiosystems.com
Dear Customer:
Ambion is supplying this letter to you as required by Section 313 of Title III of the Superfund Amendments and
Reauthorization Act commonly called SARA 313. Sec. 372.45 of SARA 313 requires that if we sell or otherwise distribute a
mixture or trade name product containing a toxic chemical or chemicals subject to the reporting requirements of SARA 313,
we must provide a written notification with the first shipment of each calendar year.
You will continue to receive this notification annually when the product is re-shipped, or if there is a change to the MSDS
(Material Safety Data Sheet). MSDSs are an important part of product information and are provided as required by OSHA
(Occupational Safety and Health Act), under the OSHA Hazard Communication Standard (29 CFR 1910.1200), for
hazardous chemicals. MSDSs include health, handling and hazard information which should be communicated to your
employees, customers and others who handle this product. Additional MSDS information can be found online at
http://www.ambion.com/techlib/detail_results.html
Additional Requirements:
鈥? If you repackage or otherwise redistribute this product, a notice with this SARA 313 information should be also sent
to the recipient of this product.
鈥? This notification must remain attached to the accompanying MSDS. Any copying or redistribution of the MSDS
shall include a copy of this notification.
This product contains:
Chemical Name CAS # W/W%
鈮? 60
ACETAMIDE 60-35-5
Please review the attached Material Safety Data Sheet for risks and handling precautions believed to be associated with this
material. If you have any additional questions or require additional information, please feel free to contact us. Thank you for
your continued support of Ambion and Applied Biosystems products.
Best regards,
Global Chemical Compliance and Risk Management
850 Lincoln Centre Drive
Foster City, CA 94404
1-800-327-3002 x2230
Chemical_Compliance@appliedbiosystems.com
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 1 of 9
MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
APPLIED BIOSYSTEMS APPLIED BIOSYSTEMS
850 LINCOLN CENTRE DRIVE 7 KINGSLAND GRANGE, WOOLSTON
FOSTER CITY, CA 94404 WARRINGTON, CHESHIRE WA1 4SR
(650) 570-6667 (USA) +44 1925 82 56 50 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
(INTERNATIONAL)
SUBSTANCE: DETECTION ENHANCER
TRADE NAMES/SYNONYMS:
US MSDS P/N 4377788; P/N 1005; P/N AM1005; P/N 2738G; P/N 1014; P/N AM1014; AgPath-ID鈩?
AIV-MATRIX GENE DETECTION KIT; AgPath-ID鈩? One-Step RT-PCR Detection Kit; 00231998
PRODUCT USE: For Research Use Only. Not for use in diagnostic procedures.
CREATION DATE: Jul 10 2006
REVISION DATE: Dec 13 2006
2. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: ACETAMIDE
CAS NUMBER: 60-35-5
PERCENTAGE: 30-60
COMPONENT: TRADE SECRET
CAS NUMBER: Not assigned.
PERCENTAGE: 30-60
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 2 of 9
3. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=1 REACTIVITY=0
EMERGENCY OVERVIEW:
PHYSICAL FORM: liquid
MAJOR HEALTH HAZARDS: eye irritation, suspect cancer hazard (in animals)
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: mild irritation, rash, nausea, drowsiness, fatigue
LONG TERM EXPOSURE: no information on significant adverse effects
SKIN CONTACT:
SHORT TERM EXPOSURE: mild irritation
LONG TERM EXPOSURE: no information on significant adverse effects
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, eye damage
LONG TERM EXPOSURE: irritation
INGESTION:
SHORT TERM EXPOSURE: rash, nausea, drowsiness, fatigue
LONG TERM EXPOSURE: reproductive effects, cancer
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give
artificial respiration if not breathing. Get immediate medical attention.
SKIN CONTACT: Wash skin with soap and water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention, if needed.
Thoroughly clean and dry contaminated clothing and shoes before reuse.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get
immediate medical attention.
INGESTION: If a large amount is swallowed, get medical attention.
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 3 of 9
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Slight fire hazard.
EXTINGUISHING MEDIA: carbon dioxide, regular dry chemical, regular foam, water
FIRE FIGHTING: Move container from fire area if it can be done without risk.
Avoid inhalation of material or combustion by-products. Stay upwind and keep
out of low areas.
FLASH POINT: not flammable
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition products or combustion: oxides of carbon, oxides of
nitrogen
6. ACCIDENTAL RELEASE MEASURES
WATER RELEASE:
Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986
(Proposition 65). Keep out of water supplies and sewers.
OCCUPATIONAL RELEASE:
Stop leak if possible without personal risk. Small spills: Absorb with sand or
other non-combustible material. Collect spilled material in appropriate
container for disposal. Notify Local Emergency Planning Committee and State
Emergency Response Commission for release greater than or equal to RQ (U.S.
SARA Section 304). If release occurs in the U.S. and is reportable under
CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA)
or (202)426-2675 (USA).
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and
standards. See original container for storage recommendations. Keep separated
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 4 of 9
from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
DETECTION ENHANCER:
No occupational exposure limits established.
VENTILATION: Provide local exhaust ventilation system. Ensure compliance with
applicable exposure limits.
EYE PROTECTION: Wear splash resistant safety goggles with a faceshield.
Provide an emergency eye wash fountain and quick drench shower in the
immediate work area.
CLOTHING: Wear appropriate chemical resistant clothing.
GLOVES: Wear appropriate chemical resistant gloves.
RESPIRATOR: Under conditions of frequent use or heavy exposure, respiratory
protection may be needed. Respiratory protection is ranked in order from
minimum to maximum. Consider warning properties before use.
Any chemical cartridge respirator with organic vapor cartridge(s).
Any chemical cartridge respirator with a full facepiece and organic vapor
cartridge(s).
Any air-purifying respirator with a full facepiece and an organic vapor
canister.
For Unknown Concentrations or Immediately Dangerous to Life or Health -
Any supplied-air respirator with full facepiece and operated in a
pressure-demand or other positive-pressure mode in combination with a
separate escape supply.
Any self-contained breathing apparatus with a full facepiece.
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 5 of 9
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
ODOR: Not available
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: Not available
PH: Not available
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition.
Avoid contact with incompatible materials.
INCOMPATIBILITIES: oxidizing materials, acids
HAZARDOUS DECOMPOSITION:
Thermal decomposition products or combustion: oxides of carbon, oxides of
nitrogen
POLYMERIZATION: Will not polymerize.
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 6 of 9
11. TOXICOLOGICAL INFORMATION
ACETAMIDE:
TOXICITY DATA:
7 gm/kg oral-rat LD50
CARCINOGEN STATUS: IARC: Human No Adequate Data, Animal Sufficient Evidence,
Group 2B
LOCAL EFFECTS:
Irritant: eye
ACUTE TOXICITY LEVEL:
Slightly Toxic: ingestion
Additional toxicological data is available on the component(s) of this product. Please call 650-638-5635
or contact MSDS_Inquiry_CCRM@appliedbiosystems.com for more information.
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: No classification assigned.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: No classification assigned.
LAND TRANSPORT ADR: No classification assigned.
LAND TRANSPORT RID: No classification assigned.
AIR TRANSPORT IATA: No classification assigned.
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 7 of 9
AIR TRANSPORT ICAO: No classification assigned.
MARITIME TRANSPORT IMDG: No classification assigned.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.30):
Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.40):
Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370.21):
ACUTE: Yes
CHRONIC: Yes
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65):
Acetamide
OSHA PROCESS SAFETY (29CFR1910.119): Not regulated.
STATE REGULATIONS:
California Proposition 65:
Known to the state of California to cause the following:
Acetamide
Cancer (Jan 01, 1990)
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: This product has been classified in accordance with
the hazard criteria of the CPR and the MSDS contains all of the
information required by the CPR.
MSDS PART NUMBER: 4377788 US
OHS PART NUMBER: 00231998
Revision number : D
Page 8 of 9
NATIONAL INVENTORY STATUS:
U.S. INVENTORY (TSCA): All the components of this substance are listed on or
are exempt from the inventory. For purposes of 40 CFR 720.36, this product
is for Research and Development (R&D) Use Only.
TSCA 12(b) EXPORT NOTIFICATION: Not listed.
16. OTHER INFORMATION
Copyright 1984-2006 MDL Information Systems, Inc. All rights reserved.
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 1 of 7
MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
AMBION, INC AMBION, INC
2130 WOODWARD ST. LTD HUNTINGDON
AUSTIN, TX 78744 CAMBIDGESHIRE, UK PE29 6XY
(512) 651-0200 (USA) +44 1480 373 020 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
WEB ADDRESS: www.ambion.com (INTERNATIONAL)
MAIL: techserv@ambion.com MAIL: eurotech@ambion.com
SUBSTANCE: 2X RT-PCR BUFFER
TRADE NAMES/SYNONYMS:
US MSDS P/N 4377786; P/N 1005; P/N AM1005; P/N 8732G; P/N 1014; P/N 1012; P/N AM1012; P/N
AM1014; P/N AM1012; P/N AM1010; AgPath-ID鈩? BVDV DETECTION KIT; AgPath-ID鈩? AIV-MATRIX
GENE DETECTION KIT; AgPath-ID鈩? ALV DETECTION KIT; AgPath-ID鈩? One-Step RT-PCR
Detection Kit; 00231996
PRODUCT USE: For Research Use Only. Not for use in diagnostic procedures.
CREATION DATE: Jul 10 2006
REVISION DATE: Dec 13 2006
2. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: TRADE SECRET
CAS NUMBER: Not assigned.
PERCENTAGE: >60
COMPONENT: TRADE SECRET 00232112
CAS NUMBER: Not assigned.
PERCENTAGE: 10-30
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 2 of 7
3. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=1 FIRE=1 REACTIVITY=0
EMERGENCY OVERVIEW:
PHYSICAL FORM: liquid
MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye
irritation
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, cough, chest pain, difficulty breathing
LONG TERM EXPOSURE: irritation, cough, difficulty breathing
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, allergic reactions
LONG TERM EXPOSURE: irritation, allergic reactions
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, eye damage
LONG TERM EXPOSURE: irritation
INGESTION:
SHORT TERM EXPOSURE: irritation (possibly severe), fever, nausea, vomiting,
diarrhea, headache, dizziness, sleep disturbances, blood disorders, kidney
damage, paralysis, reproductive effects, convulsions
LONG TERM EXPOSURE: no information on significant adverse effects
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give
artificial respiration if not breathing. Get immediate medical attention.
SKIN CONTACT: Wash skin with soap and water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention, if needed.
Thoroughly clean and dry contaminated clothing and shoes before reuse.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get
immediate medical attention.
INGESTION: If a large amount is swallowed, get medical attention.
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 3 of 7
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Slight fire hazard.
EXTINGUISHING MEDIA: carbon dioxide, regular dry chemical, regular foam, water
FIRE FIGHTING: Move container from fire area if it can be done without risk.
Avoid inhalation of material or combustion by-products. Stay upwind and keep
out of low areas.
FLASH POINT: No data available.
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition products or combustion: oxides of carbon, oxides of
nitrogen
6. ACCIDENTAL RELEASE MEASURES
OCCUPATIONAL RELEASE:
Stop leak if possible without personal risk. Small spills: Absorb with sand or
other non-combustible material. Collect spilled material in appropriate
container for disposal. Notify Local Emergency Planning Committee and State
Emergency Response Commission for release greater than or equal to RQ (U.S.
SARA Section 304). If release occurs in the U.S. and is reportable under
CERCLA Section 103, notify the National Response Center at (800)424-8802 (USA)
or (202)426-2675 (USA).
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and
standards. See original container for storage recommendations. Keep separated
from incompatible substances.
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 4 of 7
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
TRADE SECRET 00232112:
5 mg/m3 OSHA TWA (respirable dust fraction)
15 mg/m3 OSHA TWA (total dust)
10 mg/m3 OSHA TWA (total particulate) (vacated by 58 FR 35338, June 30,
1993)
10 mg/m3 ACGIH TWA
VENTILATION: Provide local exhaust ventilation system. Ensure compliance with
applicable exposure limits.
EYE PROTECTION: Wear splash resistant safety goggles with a faceshield.
Provide an emergency eye wash fountain and quick drench shower in the
immediate work area.
CLOTHING: Wear appropriate chemical resistant clothing.
GLOVES: Wear appropriate chemical resistant gloves.
RESPIRATOR: Under conditions of frequent use or heavy exposure, respiratory
protection may be needed. Respiratory protection is ranked in order from
minimum to maximum. Consider warning properties before use.
Any chemical cartridge respirator with organic vapor cartridge(s).
Any chemical cartridge respirator with a full facepiece and organic vapor
cartridge(s).
Any air-purifying respirator with a full facepiece and an organic vapor
canister.
For Unknown Concentrations or Immediately Dangerous to Life or Health -
Any supplied-air respirator with full facepiece and operated in a
pressure-demand or other positive-pressure mode in combination with a
separate escape supply.
Any self-contained breathing apparatus with a full facepiece.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
ODOR: Not available
BOILING POINT: Not available
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 5 of 7
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: 8.3
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition.
Avoid contact with incompatible materials.
INCOMPATIBILITIES: acids, bases, halogens, metals, oxidizing materials
HAZARDOUS DECOMPOSITION:
Thermal decomposition products or combustion: oxides of carbon, oxides of
nitrogen
POLYMERIZATION: Will not polymerize.
11. TOXICOLOGICAL INFORMATION
TRADE SECRET 00232112:
IRRITATION DATA:
500 mg/24 hour(s) skin-rabbit mild; 126 mg eyes-rabbit mild; 500 mg/24
hour(s) eyes-rabbit mild
TOXICITY DATA:
>570 mg/m3/1 hour(s) inhalation-rat LC50; >10 gm/kg skin-rabbit LD50; 12600
mg/kg oral-rat LD50
ACUTE TOXICITY LEVEL:
Slightly Toxic: ingestion
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 6 of 7
Additional toxicological data is available on the component(s) of this product. Please call 650-638-5635
or contact MSDS_Inquiry_CCRM@appliedbiosystems.com for more information.
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: No classification assigned.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: No classification assigned.
LAND TRANSPORT ADR: No classification assigned.
LAND TRANSPORT RID: No classification assigned.
AIR TRANSPORT IATA: No classification assigned.
AIR TRANSPORT ICAO: No classification assigned.
MARITIME TRANSPORT IMDG: No classification assigned.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.30):
Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.40):
Not regulated.
MSDS PART NUMBER: 4377786 US
OHS PART NUMBER: 00231996
Revision number : D
Page 7 of 7
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370.21):
ACUTE: Yes
CHRONIC: No
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated.
OSHA PROCESS SAFETY (29CFR1910.119): Not regulated.
STATE REGULATIONS:
California Proposition 65: Not regulated.
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: This product has been classified in accordance with
the hazard criteria of the CPR and the MSDS contains all of the
information required by the CPR.
NATIONAL INVENTORY STATUS:
U.S. INVENTORY (TSCA): Not listed on inventory. For purposes of 40 CFR
720.36, this product is for Research and Development (R&D) Use Only.
TSCA 12(b) EXPORT NOTIFICATION: Not listed.
16. OTHER INFORMATION
Copyright 1984-2006 MDL Information Systems, Inc. All rights reserved.
Ambion, INC Ambion, INC
2130 WOODWARD ST. LTD HUNTINGDON
AUSTIN, TX 78744 CAMBIDGESHIRE, UK PE29 6XY
(512) 651-0200 (USA) +44 1480 373 020 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
WEB ADDRESS: www.ambion.com (INTERNATIONAL)
MAIL: techserv@ambion.com MAIL: eurotech@ambion.com
Date: 09/19/2006
Product: Nuclease-free water
Part Number: 9914G8
OSHA Hazard Communication Standard
Ambion, Inc considers this product to be 鈥渘on-hazardous鈥? as defined under OSHA鈥檚 Hazard
Communication Standard (29 CFR 1910.1200). Therefore, we do not supply a Material Safety
Data Sheet (MSDS) for this product.
For further assistance, please send an email to: techserv@ambion.com or visit our website at:
http://www.ambion.com, then click the link for support.
U.S. EPA Toxic Substances Control Act
The United States Environmental Protection Agency (EPA), pursuant to the Toxic Substance
Control Act (TSCA), maintains an inventory of chemical substances for which information under
TSCA has been filed for distribution and use within the United States. EPA regulations allow
distribution of unlisted chemical substances for research and development (R&D), among other
exemptions. Under EPA regulations and guidelines, activities are considered R&D activities if
they are intended solely as scientific experimentation, research or analysis, including analysis,
experimentation or research on new or existing chemical substances (See EPA鈥檚 New Chemical
Information Bulletin. Exemptions for Research and Development and Test Marketing
(November, 1986)). We have been advised by the EPA that such activities include, for example,
analysis for forensic or paternity use as well as health and environmental effects testing and
efficacy and performance tests.
Ambion, Inc claims R&D exemption status under TSCA. This means that our products must be
used solely for R&D activities (that is, analysis, scientific experimentation or research, as
described above) or other activities deemed R&D activities under EPA regulations.
When using a product subject to the R&D exemption, the regulations also require that:
鈥? The activities must be conducted under the direct supervision of a technically qualified
person, who can understand and appreciate the exposure risks associated with the
material and minimize such risks.
鈥? Any unused material is disposed of according to local, state and federal regulations.
Additional information and guidance may be obtained at 40 CFR Section 720.36 or by calling the
TSCA Information Service at (202) 554-1404. A copy of the New Chemical Information Bulletin
cited above may be obtained from the TSCA Information Service.
Page 1 of 2 Rev B. August, 2006
Ambion, INC Ambion, INC
2130 WOODWARD ST. LTD HUNTINGDON
AUSTIN, TX 78744 CAMBIDGESHIRE, UK PE29 6XY
(512) 651-0200 (USA) +44 1480 373 020 (UK)
EMERGENCY CONTACT: EMERGENCY CONTACT:
1-800-424-9300 (NORTH AMERICA) +1-703-527-3887, REVERSE CHARGES
WEB ADDRESS: www.ambion.com (INTERNATIONAL)
MAIL: techserv@ambion.com MAIL: eurotech@ambion.com
Date: 09/19/2006
Product: Nuclease-free water
Part Number: 9914G8
This product is not classified as a 鈥榙angerous substance鈥? or 鈥榙angerous preparation鈥? according to
the criteria of European Directives 67/548/EEC (as amended) or 1999/45/EC. Therefore, we do
not supply a Safety Data Sheet (SDS) for this product.
For further assistance, please send an email to:
techserv@ambion.com or visit our website at:
http://www.ambion.com, then click the link for support.
Page 2 of 2 Rev B. August, 2006
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