Phorbol Myristate Acetate (PMA) Safety Data Sheet
Date: 02-02-05 Date of printing: 22-02-05 Page 1 of 2
1. Name of substance/preparation and company
1.1 Commercial product: Phorbol Myristate Acetate (PMA)
Cat.-No.: tlrl-pma
1.2 Company: CAYLA SAS- InvivoGen Corp.
5 rue Jean Rodier BP 4437 3950 Sorrento Valley Blvd
31 405 Toulouse Cedex 04 France San Diego, California 92 121 USA
Tel. ++33 (0)5 62 71 69 39 858 457 5873
Information obtainable from: ++33 (0)5 62 71 69 39 858 457 5873
This product is for laboratory use only and is not intended for human or animal diagnostics, therapeutic or clinical uses
2. Composition/Information on constituents
The following list shows components of this product classified as hazardous based on physical properties and health effects
No component classified as hazardous component
Origin: synthetic
CAS-No.:63597-44-4
Molecular weight: C36H56O8
EC number: None
3. Hazards identification
Warnings: The usual precautions when handling chemicals and phorbal derivates should be observed.
Potential health effects:
Phorbal derivates are purgatives if taken internally; Tumor promotor
- Eyes: May cause irritation.
- Skin contact: Can cause moderate skin irritation,
- Skin absorption : may be harmful if absorbed trough skin
- Inhalation: May be irritating to mucous membranes and upper respiratory tract. May be harmful if swallowed,
- Ingestion: may be harmful if swallowed,
4. First aid measures
First aid:
Eye contact: Wash immediately eyes with plenty of water for at least 15 minutes. Get medical attention;
Skin contact: Wash off with water and soap, remove contaminated clothes. Get medical attention
Ingestion: give plenty of water if conscious. If vomiting occurs naturally, wash mouth out. Be prepared to induce vomiting upon advice. Obtain
medical attention if symptoms develop.
Inhalation: Remove victim to fresh air, if malaise develops go to a physician
Instructions for symptomatic treatment by a physician: Treat symptomatically
5. Fire-fighting measures
Flash point Degree : Not available
Upper flammable limit %: Not available
Lower flammable limit %: Not available
Autoignition temperature degree: Not available
Extinguishing media: Use alcohol or resistant foam, carbon dioxide or dry chemical fighting fire.
Hazardous combustion products: toxic fumes of carbon dioxide, carbon monoxide, nitrogen oxides,
6. Accidental release measures
Refer to section 8 for personal protection equipment recommendations.
After spillage: Sweep up spilled substance carefully.
Absorbent material: suitable absorbent material like .
Damage limitation: Special measures to limit damage are to be taken.
7. Handling and storage
Storage of some material could be regulated by federal, state, and/or local laws.
7.1 Handling: Avoid contacting and breathing the material, avoid accidental autoinoculation.
Do not mouth pipette, do not come into contact with open wounds.
Use extreme caution when handling this compound with carcinogenic compounds.
7.2 Storage: Store in -20掳C at ambient pressure, and in suitable storage area.
Hydrophilic material; Keep tightly closed when not in use
Condition to avoid: light
Phorbol Myristate Acetate (PMA) Safety Data Sheet
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Date: 02.02-05 Date of printing: 22-02-05 Page 2 of 2
8. Exposure controls- personal protection
Engineering controls : local exhaust ventilation or other engineering controls are normally required when handling or using this product to avoid
overexposure.
Respiratory protection: protective respiratory mask is highly recommended
Eye protection: wear protective glasses
Hand protection: wear protective compatible resistant gloves
Hygiene: Wash hands before breaks and at the end of the work.
9. Physical and chemical properties
Physical state :lipidic film
Colour: translucide
Odor: none
PH: N.A.
Boiling point:N/A
Melting point: N/A
Solubility in water: DMSO/Methanol/Ethanol/Chloroform
Density : N/A
Viscosity: not determined
10. Stability and reactivity
Stability : stable under normal conditions
Light sensitvie
Reactions: Not known when used appropriately.
Hazardous decomposition products : Carbon monoxide, Carbon dioxide. Nitrogen oxides
Hazardous polymerisation: will not occur
11. Toxicological information
LD50 oral/ingestion : not known
LD50 dermal not known
LD50 inhalation/respiratory not known
Chronic exposure: CARCINOGEN
Phorbol esters are the most potent tumor promoters known to man. Some of the phorbol esters enhance tumor promotion of known carcinogens ten
fold
12. Ecological information
Hazards: no hazardous substance to water and ground water even if no ecological information is available
Environmental fate: Bioconcentration is not expected to occur
13. Disposal considerations
Regulatory information: not applicable
Waste disposal route: Can be sent to an incineration plant in accordance with all state, federal, local regulations.
Clean up and dispose of waste in accordance with all state, federal, local regulations.
14. Transport information
UN number
ICAO/IATA:
Proper Shipping Name: Phorbol Myristate Acetate
Notes: product non subject to current regulations for transportation of hazardous goods (GGVS/ADR,
GGVE/RID, IMDG, IATA/ICAO).
Hazard class Non hazardous component,
15. Regulatory Information
Notes: This product is not subject to labelling in accordance with EEC regulation on toxic product
R26/2728 Toxic product must be labelled with skin and in if swallowed
This by inhalation, in contact in accordance with EEC regulation on product class 6.1, Xn.
R48 Danger of serious damageor ifprolonged exposure
toxic in case of ingestion by swallowed
S24/26 Avoid contact with skin and eyes
Avoid contact with skin and eyes
S36/37/39 Wear protective clothing, respiratory mask, gloves and eyes protection
Wear protective clothing, respiratory mask, gloves and eyes protection
16. Other information
The information herein is believed to be correct as of the date hereof, but is provided without warranty
of any kind. The recipient of our product is responsible for ensuring that, where applicable, existing
laws and guidelines are observed.
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