SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 10/FEB/2005
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TETRAETHYLTHIURAM DISULFIDE CRYSTALLINE
Product Number T1132
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DISULFIRAM TETRAETHYLTHIURAM 97-77-8 202-607-8 006-079-00-8
DISULFIDE
Formula C10H20N2S4
Molecular Weight 296.54 AMU
Synonyms Abstensil * Abstinil * Abstinyl * Alcophobin *
Antabus * Antabuse * Antaenyl * Antaethyl *
Antalcol * Antetan * Antetil * Anti-ethyl *
Antietil * Antikol * Antivitium * Aversan *
Averzan *
Bis((diethylamino)thioxomethyl)disulphide *
Bis(diethylthiocarbamoyl) disulfide *
Bis(N,N-diethylthiocarbamoyl) disulfide *
Bis(diethylthiocarbamoyl)disulphide *
Bis(N,N-diethylthiocarbamoyl)disulphide *
Contralin * Cronetal * Dicupral * Disulfiram
(ACGIH) * Disulfuram * Disulphuram *
1,1'-Dithiobis(N,N-diethylthioformamide) * Dupon
4472 * Dupont fungicide 4472 * Ekagom TEDS * ENT
27,340 * Ephorran * Espenal * Esperal * Etabus *
Ethyldithiourame * Ethyldithiurame * Ethyl
thiram * Ethyl thiurad * Ethyl tuads * Ethyl
TUEX * Exhoran * Formamide,
1,1'-dithiobis(N,N-diethylthio- * HOCA *
Krotenal * NCI-C02959 * Nocbin * Noxal * NSC
190940 * Refusal * Ro-Sulfiram * Stopetyl *
Tenurid * Tenutex * TETD * Tetidis * Tetradin *
Tetradine * Tetraethylthioperoxydicarbonic
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. May cause sensitization by skin contact.
Also harmful: danger of serious damage to health by prolonged
exposure if swallowed. Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing dust. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
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Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 2 mg/m3
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 2 mg/m3, E
Remarks: 4
Remarks: 20
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 2 mg/m3
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level8 mg/m3
Remarks: S
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 2 mg/m3
Remarks: E D* S*
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 69 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
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Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: JO1225000
ACUTE TOXICITY
LDLO
Oral
Woman
90 mg/kg
18D-I
Remarks: Behavioral:Coma. Liver:Jaundice, other or unclassified.
Kidney, Ureter, Bladder:Changes in tubules (including acute
renal failure, acute tubular necrosis).
LDLO
Oral
Man
150 mg/kg
6W-I
Remarks: Liver:Hepatitis (hepatocellular necrosis), diffuse.
LDLO
Oral
Human
160 mg/kg
Remarks: Behavioral:Coma. Gastrointestinal:Ulceration or
bleeding from large intestine. Liver:Hepatitis, fibrous
(cirrhosis, post-necrotic scarring).
LD50
Oral
Rat
500 mg/kg
LD50
Intraperitoneal
Rat
248 MG/KG
Remarks: Behavioral:Change in motor activity (specific assay).
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
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LD50
Oral
Mouse
1980 mg/kg
LD50
Intraperitoneal
Mouse
75 MG/KG
LD50
Subcutaneous
Mouse
2600 MG/KG
LD50
Oral
Rabbit
1800 mg/kg
Remarks: Peripheral Nerve and Sensation:Flaccid paralysis
without anesthesia (usually neuromuscular blockage).
Behavioral:Ataxia. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
IRRITATION DATA
Eyes
Rabbit
100 mg
Remarks: Mild irritation effect
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
A serious toxic interaction has been observed in rats fed
tetraethylthiuram (antabuse, ro-sulfiram) and then exposed to
vapors of 1,2-dibromoethane. Ingestion of ethyl alcohol may
result in: nausea, vomiting, pallor, hypotension, dizziness,
headache, dyspnea, convulsions, cardiac arrhythmias,
unconsciousness, and death. May cause acneform eruptions,
allergic dermatitis, urticaria, lassitude, reduced sexual
potency, a garlic-like or metallic taste. Peripheral neuritis,
polyneuritis and optic neuritis as well as both cholestatic and
fulminant hepatitis have been reported. Sensitization to alcohol
may last for as long as 6 to 14 days after last ingestion of
tetraethylthiuram disulfide.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CONDITIONS AGGRAVATED BY EXPOSURE
May cause nervous system disturbances.
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CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Subcutaneous
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Blood:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Rat
12600 MG/KG
Oral
6W
Morphological transformation.
Mouse
16 UG/L
Cell Type: lymphocyte
specific locus test
Mouse
10 MG/L
Cell Type: Embryo
DNA inhibition
Mouse
200 MG/KG
Oral
Sister chromatid exchange
Hamster
20 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
5 UMOL/L
Cell Type: ovary
Sister chromatid exchange
Chicken
120 NMOL/L
Cell Type: Embryo
DNA inhibition
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Chicken
120 NMOL/L
Cell Type: Embryo
Other mutation test systems
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 400 MG/KG
Route of Application: Parenteral
Exposure Time: (4-11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 800 MG/KG
Route of Application: Parenteral
Exposure Time: (2D MALE/2D PRE)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 1278 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 5 GM/KG
Route of Application: Oral
Exposure Time: (3-12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 310 MG/KG
Route of Application: Oral
Exposure Time: (31D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 13200 MG/KG
Route of Application: Oral
Exposure Time: (15D PRE/1-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 39200 MG/KG
Route of Application: Oral
Exposure Time: (7-14D PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Species: Mouse
Dose: 1278 MG/KG
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Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Extra embryonic structures (e.g., placenta, umbilical cord).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 006-079-00-8
INDICATION OF DANGER: Xn N
Harmful. Dangerous for the environment.
R-PHRASES: 22 43 48/22 50/53
Harmful if swallowed. May cause sensitization by skin contact.
Also harmful: danger of serious damage to health by prolonged
exposure if swallowed. Very toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
S-PHRASES: 24 37 60 61
Avoid contact with skin. Wear suitable gloves. This material
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and its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special
instructions/safety data sheets.
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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