SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TETRACYCLINE
Product Number 87128
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TETRACYCLINE FREE BASE 60-54-8 200-481-9 None
Formula C22H24N2O8
Molecular Weight 444.44 AMU
Synonyms Abramycin * Abricycline * Achromycin
(naphthracene derivatives) * Agromicina *
Ambramicina * Ambramycin * Amycin * Biocycline *
Cefracycline suspension * Criseociclina *
Cyclomycin * Cytome * Deschlorobiomycin *
Hostacyclin * Liquamycin * Medocycline *
6-Methyl-1,11-dioxy-2-naphthacenecarboxamide *
Micycline * Neocycline * Oletetrin * Omegamycin
* Orlycycline * Panmycin * Polycycline
(antibiotic) * Resteclin * Roviciclina * Sumycin
syrup * Tetrabon * Tetra-Co * Tetracycline *
Tetracycline I * Tetracycline II * Tetracyn *
Tetradecin * Tetrafil * Tsiklomitsin * T-125 *
Veracin * Vetacyclinum
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
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Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Yellow
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 172 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content 4 - 11 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: QI8750000
ACUTE TOXICITY
LDLO
Multiple
Woman
310 MG/KG
Remarks: Gastrointestinal:Nausea or vomiting. Liver:Jaundice,
other or unclassified. Nutritional and Gross Metabolic:Changes
in:Metabolic acidosis.
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LD50
Oral
Rat
807 mg/kg
LD50
Intraperitoneal
Rat
310 MG/KG
LD50
Intravenous
Rat
129 MG/KG
LD50
Oral
Mouse
678 mg/kg
LD50
Intraperitoneal
Mouse
120 MG/KG
LD50
Subcutaneous
Mouse
400 MG/KG
LD50
Intravenous
Mouse
157 MG/KG
LD50
Oral
Guinea pig
1875 mg/kg
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
Skin: Can cause skin photosensitization.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause phototoxic reactions, gastrointestinal disturbances,
turn teeth yellow and reduce mineralization.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Teeth. Bones.
CHRONIC EXPOSURE - CARCINOGEN
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Result: This product is or contains a component that is probably
not carcinogenic based on its IARC, ACGIH, NTP, or EPA
classification.
CHRONIC EXPOSURE - MUTAGEN
Mouse
110 MG/KG
Intraperitoneal
24H
Micronucleus test
S. typhimurium
ZNEG
Histidine reversion (Ames)
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 100 UG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-20D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 1 MG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-20D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 3 GM/KG
Route of Application: Unreported
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (14D POST)
Result: Specific Developmental Abnormalities: Skin and skin
appendages.
Species: Mammal
Dose: 55 MG/KG
Route of Application: Intravenous
Exposure Time: (8-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 200 MG/KG
Route of Application: Unreported
Exposure Time: (34-35W PREG)
Result: Effects on Newborn: Delayed effects.
Species: Woman
Dose: 80 MG/KG
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Route of Application: Unreported
Exposure Time: (1-39W PREG)
Result: Effects on Newborn: Other postnatal measures or effects.
Species: Rat
Dose: 10 GM/KG
Route of Application: Oral
Exposure Time: (8-21D PREG/7D POST)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 863 MG/KG
Route of Application: Oral
Exposure Time: (4D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Rat
Dose: 413 MG/KG
Route of Application: Oral
Exposure Time: (3D POST)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Physical.
Species: Rat
Dose: 700 MG/KG
Route of Application: Intramuscular
Exposure Time: (8-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
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S-PHRASES: 22 36
Do not breathe dust. Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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