SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAY/2005
Date Updated: 03/FEB/2005
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name TETRACYCLINE HYDROCHLORIDE
Product Number 87130
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
TETRACYCLINE HYDROCHLORIDE 64-75-5 200-593-8 None
Formula C22H24N2O8路HCl
Molecular Weight 480.91 AMU
Synonyms Achromycin hydrochloride * ALA TET * Amycin,
hydrochloride * Artomycin * Bristacycline *
Cancycline-250 * Cefracycline tablets *
Chlorhydrate de tetracycline (French) *
Chlorowodorku tetracykliny (Polish) * Cyclopar *
Diacycine * Dumocyclin * Hostacycline *
Medamycin * Mephacyclin * NCI-C55561 *
Neocycline B * Paltet * Panmycin hydrochloride *
Partrex * Piracaps * Polycycline hydrochloride *
Polyotic ointment * Qidtet * Quadracycline *
Quatrex * Remicyclin * Ricycline * Ro-Cycline *
Sanclomycine * Steclin * Stilciclina * Subamycin
* Sumycin * Supramycin * Tefilin * Teline *
Telotrex * Tet-Cy * Tetrabakat * Tetrabid *
Tetrablet * Tetracaps * Tetrachel * Tetraciclina
cloridrato (Italian) * Tetracompren *
Tetracycline chlorohydrate * Tetracycline
hydrochloride * Tetra-D * Tetrakap * Tetralution
* Tetramavan * Tetra-wedel * Tetrosol *
Topicycline * Triphacyclin * U-5965 * Unicin *
Unimycin * Vetquamycin-324
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
FLUKA - 87130 www.sigma-aldrich.com Page 2
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 220 - 223 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: QI9100000
ACUTE TOXICITY
LD50
Oral
Rat
6443 mg/kg
LD50
Intraperitoneal
Rat
318 MG/KG
FLUKA - 87130 www.sigma-aldrich.com Page 3
LD50
Subcutaneous
Rat
700 MG/KG
Remarks: Gastrointestinal:Hypermotility, diarrhea.
LD50
Intravenous
Rat
128 MG/KG
LD50
Oral
Mouse
2759 mg/kg
LD50
Intraperitoneal
Mouse
368 MG/KG
LD50
Intravenous
Mouse
157 MG/KG
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause phototoxic reactions, gastrointestinal disturbances,
turn teeth yellow and reduce mineralization.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Teeth. Bones.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is probably
not carcinogenic based on its IARC, ACGIH, NTP, or EPA
classification.
CHRONIC EXPOSURE - MUTAGEN
Human
500 UMOL/L
Cell Type: fibroblast
DNA damage
Human
750 UMOL/L
Cell Type: fibroblast
Unscheduled DNA synthesis
FLUKA - 87130 www.sigma-aldrich.com Page 4
Human
1250 UMOL/L
Cell Type: fibroblast
DNA inhibition
Rat
200 UMOL/L
Cell Type: liver
DNA damage
Mouse
31600 UG/L
Cell Type: mammary gland
DNA inhibition
Mouse
31600 UG/L
Cell Type: mammary gland
Other mutation test systems
Mouse
31600 UG/L
24H
Cell Type: mammary gland
Cytogenetic analysis
Mouse
120 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
100 MG/L
Cell Type: mammary gland
Mutation in mammalian somatic cells.
Hamster
3 MG/L
Cell Type: Embryo
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
Species: Rat
Dose: 14 GM/KG
Route of Application: Oral
Exposure Time: (3D MALE/3D PRE-22D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 240 MG/KG
Route of Application: Subcutaneous
Exposure Time: (16-20D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Species: Rat
Dose: 240 MG/KG
Route of Application: Intramuscular
Exposure Time: (10-15D PREG)
FLUKA - 87130 www.sigma-aldrich.com Page 5
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-13D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 150 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 2250 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-18D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Effects on Newborn: Viability index (e.g., # alive at day 4 per
# born alive). Effects on Newborn: Growth statistics (e.g.,
reduced weight gain).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 6 GM/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 425 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (14-18D PREG)
Result: Effects on Fertility: Abortion. Effects on Embryo or
Fetus: Extra embryonic structures (e.g., placenta, umbilical
cord).
Species: Rat
Dose: 450 MG/KG
Route of Application: Unreported
Exposure Time: (7-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 765 MG/KG
Route of Application: Unreported
Exposure Time: (7-15D PREG)
Result: Effects on Fertility: Abortion.
Species: Rat
Dose: 100 MG/KG
Route of Application: Intrauterine
Exposure Time: (1D PRE)
FLUKA - 87130 www.sigma-aldrich.com Page 6
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse
Dose: 900 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8-13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 750 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1-6D PREG)
Result: Effects on Fertility: Abortion.
Species: Mouse
Dose: 2250 MG/KG
Route of Application: Parenteral
Exposure Time: (10-18D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rabbit
Dose: 9 GM/KG
Route of Application: Oral
Exposure Time: (8-16D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36/37/38
Irritating to eyes, respiratory system and skin.
FLUKA - 87130 www.sigma-aldrich.com Page 7
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
FLUKA - 87130 www.sigma-aldrich.com Page 8
|