SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 08/JUN/2005
Date Updated: 13/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name FORMAMIDE
Product Number F7503
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
FORMAMIDE 75-12-7 200-842-0 616-052-00-8
Formula CH3NO
Molecular Weight 45.04 AMU
Synonyms Amid kyseliny mravenci (Czech) * Carbamaldehyde
* Formamide (ACGIH) * Formimidic acid *
Methanamide * Methanoic acid, amide
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause harm to the unborn child.
Repr. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not
breathe mist. Do not get in eyes, on skin, on clothing. Avoid
prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
USA ACGIH TLV 18 mg/m3
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 18 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 18 mg/m3
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Remarks: H,NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 18 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level20 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 18 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 37 mg/m3
20 ppm
OEL STEL 56 mg/m3
30 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH 4-5
BP/BP Range 210 掳C 760 mmHg
MP/MP Range 2 掳C
Flash Point 150 掳C Method: closed cup
Flammability N/A
Autoignition Temp 500 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.7 %
Upper: 19 %
Vapor Pressure 0.08 mmHg 20 掳C
SG/Density 1.132 g/cm3
Partition Coefficient Log Kow: -1.51
Viscosity N/A
Vapor Density 1.55 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. 180 掳C
Solvent Content N/A
Water Content < 0.1 %
Surface Tension N/A
Conductivity N/A
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Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Acids, Bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: LQ0525000
ACUTE TOXICITY
LD50
Oral
Rat
5,577 mg/kg
LD50
Oral
Mouse
3,150 mg/kg
LD50
Skin
Rabbit
17,000 mg/kg
LC50
Inhalation
Rat
3,900 mg/kg
6 HR.
LD50
Oral
Rat
5577 mg/kg
Remarks: Autonomic Nervous System:Other (direct)
parasympathomimetic. Behavioral:Ataxia. Kidney, Ureter,
Bladder:Incontinence.
LC50
Inhalation
Rat
> 3,900 ppm
6H
LD50
Intraperitoneal
Rat
5700 MG/KG
LD50
Subcutaneous
Rat
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>4 GM/KG
LD50
Oral
Mouse
3150 mg/kg
LD50
Intraperitoneal
Mouse
2450 MG/KG
LD50
Skin
Rabbit
17000 mg/kg
LD50
Intraperitoneal
Guinea pig
1250 MG/KG
Remarks: Autonomic Nervous System:Other (direct)
parasympathomimetic. Behavioral:Somnolence (general depressed
activity). Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Mammal
3150 mg/kg
IRRITATION DATA
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Gastrointestinal disturbances. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Readily absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Vapor or mist is
irritating to the mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Blood. Central nervous system. Liver. Kidneys.
CONDITIONS AGGRAVATED BY EXPOSURE
Material can cause severe burns and blistering which may not be
immediately painful or visible. The full extent of tissue damage
may not exhibit itself for 12-24 hours after exposure.
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
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Species: Rat
Dose: 7980 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 1200 MG/KG
Route of Application: Skin
Exposure Time: (10-11D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 2 GM/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rabbit
Dose: 910 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
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ANNEX I INDEX NUMBER: 616-052-00-8
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 61
May cause harm to the unborn child.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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