SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/FEB/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CEFOTAXIME SODIUM
Product Number C7912
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CEFOTAXIM SODIUM SALT* 64485-93-4 264-915-9 None
Formula C16H16N5NaO7S2
Molecular Weight 477.5 AMU
Synonyms Cefotaxime sodium * Claforan * CTX * HR 756 *
Sodium
7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamid
o)cephalosporanate * RU 24756
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause sensitization by inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Color: Very faintly beige
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
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Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content <4%
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:50 mg/ml H2O clear,
faintly yellow
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sulfur oxides, Nitrogen oxides, Sodium/sodium oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: XI0250000
ACUTE TOXICITY
LD50
Oral
Rat
> 20000 mg/kg
Remarks: Behavioral:Food intake (animal). Behavioral:Ataxia.
Lungs, Thorax, or Respiration:Other changes.
LD50
Intraperitoneal
Rat
10 GM/KG
Remarks: Behavioral:Food intake (animal). Behavioral:Ataxia.
Lungs, Thorax, or Respiration:Other changes.
LD50
Subcutaneous
Rat
18400 MG/KG
Remarks: Behavioral:Food intake (animal). Behavioral:Ataxia.
Lungs, Thorax, or Respiration:Other changes.
LD50
Intravenous
Rat
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7 GM/KG
LD50
Intramuscular
Rat
>2 GM/KG
LD50
Oral
Mouse
> 20000 mg/kg
Remarks: Behavioral:Food intake (animal). Behavioral:Ataxia.
Lungs, Thorax, or Respiration:Other changes.
LD50
Intraperitoneal
Mouse
10 GM/KG
LD50
Subcutaneous
Mouse
12950 MG/KG
LD50
Intravenous
Mouse
6845 MG/KG
LD50
Intravenous
Dog
>1500 MG/KG
LD50
Intramuscular
Dog
>716 MG/KG
LD50
Intravenous
Rabbit
1880 MG/KG
Remarks: Behavioral:Food intake (animal). Behavioral:Ataxia.
Lungs, Thorax, or Respiration:Other changes.
SENSITIZATION
Sensitization: May cause allergic reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Because of the similarity in structure of the penicillins and
cephalosporins, those who are allergic to one class of agents
may manifest cross-allergenicity when a member of the other
class is encountered. May cause gastrointestinal disturbances,
hypersensitivity reactions, neutropenia, rise in liver enzymes,
rise in blood urea nitrogen. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract.
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Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption. Causes eye and skin irritation.
CHRONIC EXPOSURE - TERATOGEN
Species: Rabbit
Dose: 325 MG/KG
Route of Application: Intravenous
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 42/43
May cause sensitization by inhalation and skin contact.
S-PHRASES: 22 36/37
Do not breathe dust. Wear suitable protective clothing and
gloves.
16 - Other Information
DISCLAIMER
For R&D or manufacturing use. Not for prescription compound or
other uses.
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