SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/FEB/2005
Date Updated: 13/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CATECHOL CRYSTALLINE
Product Number C9510
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CATECHOL 120-80-9 204-427-5 604-016-00-4
Formula C6H6O2
Molecular Weight 110.11 AMU
Synonyms Benzene, o-dihydroxy- * o-Benzenediol *
1,2-Benzenediol * Catechin (phenol) * Catechol
(ACGIH) * Catechol (phenol) * C.I. 76500 * C.I.
Oxidation Base 26 * o-Dihydroxybenzene *
1,2-Dihydroxybenzene * o-Dioxybenzene *
o-Diphenol * Durafur developer C * Fouramine PCH
* Fourrine 68 * o-Hydroquinone * o-Hydroxyphenol
* 2-Hydroxyphenol * Katechol (Czech) *
NCI-C55856 * Oxyphenic acid * Pelagol Grey C *
o-Phenylenediol * Phthalhydroquinone *
Pyrocatechin * Pyrocatechine * Pyrokatechin
(Czech)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful in contact with skin and if swallowed. Irritating to eyes
and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place. Store under inert gas.
SPECIAL REQUIREMENTS: Store under inert gas. Air and light
sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
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OEL TWA 20 mg/m3
5 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 20 mg/m3, E
Remarks: H,NL
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 20 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 23 mg/m3
5 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 23 mg/m3
5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 245 掳C 760 mmHg
MP/MP Range 104 掳C
Flash Point 127 掳C Method: closed cup
Flammability N/A
Autoignition Temp 510 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.97 %
Vapor Pressure 1 mmHg 75 掳C
SG/Density N/A
Partition Coefficient Log Kow: 0.88
Viscosity N/A
Vapor Density 3.8 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Other Solvents: ETHER, CARBON TETRACHLORIDE
SOLUBLE IN CHLOROFORM, ACETAT VERY SOLUBLE
IN PYRIDINE
10 - Stability and Reactivity
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STABILITY
Stable: Stable.
Conditions of Instability: May discolor on exposure to air. May
discolor on exposure to light.
Materials to Avoid: Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: UX1050000
ACUTE TOXICITY
LD50
Oral
Rat
260 mg/kg
LD50
Oral
Mouse
260 mg/kg
LD50
Intraperitoneal
Mouse
68 MG/KG
LD50
Subcutaneous
Mouse
247 MG/KG
LD50
Oral
Dog
130 mg/kg
LD50
Oral
Cat
100 mg/kg
LD50
Skin
Rabbit
800 mg/kg
Remarks: Skin and Appendages:Skin: After topical
exposure:Primary irritation. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
LD50
Oral
Guinea pig
210 mg/kg
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LD50
Oral
Mammal
240 mg/kg
Remarks: Behavioral:Change in motor activity (specific assay).
Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Dyspnea.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Kidneys. Liver.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 96W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Rat
Route of Application: Oral
Exposure Time: 24W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Gastrointestinal:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Rat
Route of Application: Oral
Exposure Time: 51W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
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IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: lymphocyte
DNA damage
Human
200 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Human
40 UMOL/L
Cell Type: lymphocyte
Other mutation test systems
Human
40 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
3 MMOL/L
Cell Type: liver
DNA damage
Rat
1 GM/KG
Oral
Unscheduled DNA synthesis
Mouse
40 MG/KG
Oral
Micronucleus test
Mouse
10 MG/KG
Intraperitoneal
Micronucleus test
Mouse
500 UMOL/L
Cell Type: lymphocyte
DNA damage
Mouse
250 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Mouse
2500 UG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
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25 UMOL/L
Cell Type: lung
Micronucleus test
Hamster
1 UMOL/L
Cell Type: Embryo
Morphological transformation.
Hamster
1 UMOL/L
Cell Type: Embryo
Unscheduled DNA synthesis
Hamster
3 UMOL/L
Cell Type: Embryo
Cytogenetic analysis
Hamster
50 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
12500 NMOL/L
Cell Type: lung
Sister chromatid exchange
Hamster
10 UMOL/L
Cell Type: Embryo
Sister chromatid exchange
Hamster
30 UMOL/L
Cell Type: Embryo
SLN
Hamster
10 UMOL/L
Cell Type: Embryo
Mutation in mammalian somatic cells.
Rabbit
2 MMOL/L
Cell Type: Bone marrow
Other mutation test systems
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (11D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rat
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
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Result: Maternal Effects: Ovaries, fallopian tubes.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 8.9 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 3.5 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 604-016-00-4
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 21/22 36/38
Harmful in contact with skin and if swallowed. Irritating to
eyes and skin.
S-PHRASES: 22 26 37
Do not breathe dust. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
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suitable gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 2
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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