SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 11/SEP/2005
Date Updated: 17/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name GLYCIDOL, 96%
Product Number G5809
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(+/-)-GLYCIDOL 556-52-5 209-128-3 603-063-00-8
Ingredient Name Percent CAS # EC no Annex I
Oxirane, <= 2 2238-07-5 218-802-6 None
2,2'-[oxybis(methylene)]b
is-
Formula C3H6O2
Molecular Weight 74.08 AMU
Synonyms Epihydrin alcohol * 2,3-Epoxypropanol *
2,3-Epoxy-1-propanol (ACGIH:OSHA) * Glycide *
Glycidol (ACGIH:OSHA) * Glycidyl alcohol *
3-Hydroxy-1,2-epoxypropane * Methanol, oxiranyl-
* NCI-C55549
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. May impair fertility. Also harmful in contact
with skin and if swallowed. Also toxic by inhalation. Irritating
to eyes, respiratory system and skin. Also possible risks of
irreversible effects.
Carc. Cat.2 Muta. Cat.3 Repr. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Combustible.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
ALDRICH - G5809 www.sigma-aldrich.com Page 2
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 6 mg/m3
Poland NDSCh -
Poland NDSP
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 1 mg/m3
0.2 ppm
Remarks: L
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 150 mg/m3
50 ppm
Remarks: =1=
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 75 mg/m3
25 ppm
Remarks: A
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 75 mg/m3
25 ppm
Remarks: P
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 162.0 - 165.0 掳C
MP/MP Range N/A
Flash Point 66 掳C Method: closed cup
Flammability N/A
Autoignition Temp 416 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.115 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2.15 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
ALDRICH - G5809 www.sigma-aldrich.com Page 3
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to moist air
or water.
Materials to Avoid: Heavy metals, Strong bases, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: UB4375000
ACUTE TOXICITY
LD50
Oral
Rat
420 mg/kg
LC50
Inhalation
Rat
580 ppm
8H
Remarks: Lungs, Thorax, or Respiration:Other changes. Lungs,
Thorax, or Respiration:Emphysema.
LD50
Intraperitoneal
Rat
200 MG/KG
LD50
Oral
Mouse
431 mg/kg
LC50
Inhalation
Mouse
450 ppm
4H
Remarks: Lungs, Thorax, or Respiration:Emphysema. Lungs, Thorax,
or Respiration:Other changes.
LD50
Intraperitoneal
Mouse
500 MG/KG
ALDRICH - G5809 www.sigma-aldrich.com Page 4
LD50
Skin
Rabbit
1980 mg/kg
IRRITATION DATA
Skin
Rabbit
558 mg
3D
Remarks: Moderate irritation effect
Skin
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
2 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Can cause CNS depression.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Readily absorbed through skin. Harmful if
absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: Toxic if inhaled. Material is irritating to mucous
membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors. Skin and Appendages: Other: Tumors.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Gastrointestinal:Tumors. Tumorigenic:Carcinogenic by
RTECS criteria. Skin and Appendages: Other: Tumors.
CHRONIC EXPOSURE - MUTAGEN
Human
400 UMOL/L
Cell Type: lymphocyte
Cytogenetic analysis
ALDRICH - G5809 www.sigma-aldrich.com Page 5
Human
50 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
320 MG/KG
Intraperitoneal
Cytogenetic analysis
Rat
600 MG/KG
Oral
Cytogenetic analysis
Mouse
1250 UG/KG
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
10 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
12500 UG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
10100 UG/L
Cell Type: ovary
Sister chromatid exchange
Hamster
1250 UMOL/L
Cell Type: lung
Sister chromatid exchange
Hamster
1 UMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 2 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 180 MG/KG
Route of Application: Oral
ALDRICH - G5809 www.sigma-aldrich.com Page 6
Exposure Time: (12D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Rat
Dose: 18200 MG/KG
Route of Application: Oral
Exposure Time: (13W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 500 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (5D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Mouse
Dose: 6825 MG/KG
Route of Application: Oral
Exposure Time: (13W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2810
Class: 6.1
PG: III
Proper Shipping Name: Toxic liquid, organic, n.o.s.
IMDG
UN#: 2810
Class: 6.1
PG: III
Proper Shipping Name: Toxic liquid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2810
Class: 6.1
PG: III
Proper Shipping Name: Toxic liquid, organic, n.o.s.
Inhalation Packing Group I: No
ALDRICH - G5809 www.sigma-aldrich.com Page 7
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-063-00-8
NOTA: E
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45-60-21/22-23-36/37/38-68
May cause cancer. May impair fertility. Also harmful in contact
with skin and if swallowed. Also toxic by inhalation.
Irritating to eyes, respiratory system and skin. Also possible
risks of irreversible effects.
S-PHRASES: 53-45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Declaration Number: 66725
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - G5809 www.sigma-aldrich.com Page 8
|