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Biomolecules for research                           MATERIAL SAFETY DATA SHEET







Section 1 : Substance Identification



              Amifostine

     Name:                                                  CAS Number:        20537-88-6



     Catalog Number:      GR-341                            Chemical Formula:      C5H15N2O3PS



     Chemical Name:      2-(3-Aminopropyl)aminoethyl phosphorothioate



     Synonyms:      WR2721



     Chemical Class:    Not Available



     Company Identification:     BIOMOL International L.P.

                                 5120 Butler Pike

                                 Plymouth Meeting PA 19462-1202 USA

                                 (610) 941-0430 (9am-5pm ET)









Section 2 : Health Hazard Data



     Acute Health Effects:     Active pharmaceutical ingredient. Exercise appropriate precautions to prevent

     overexposure via inhalation, or contact with the eyes. May cause irritation of mucus membranes. May be

     harmful if ingested.

     Chronic Health Effects:      unknown

     Target Organs: Cardiovascular system







Section 3 : First Aid Measures



     Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15

             minutes separating eyelids. Seek medical attention immediately.

     Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.

             Seek medical attention immediately.

     Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,

             administer artificial respiration. Seek medical attention immediately. Provide chemical label

             and MSDS if possible.

      Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call

              physician or poison control immediately. Provide chemical label and MSDS information if

              possible.









Section 4 : Fire and Explosion Data





      Flammability: Not Available

      Flash Point: Not Available

      Combustion Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides,

              Phosphorous oxides

      Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray

      Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to

              prevent contact with skin and eyes.

      Unusual Fire/Explosion Hazards: None known









 Section 5 : Spill or Leak Procedures



      Cleanup Procedures:      Wearing appropriate protective gear as outlined under "Protective Equipment"

            wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate

            the area and wash spill site after material has been removed.

      Waste Disposal Method:      Observe all Federal, State and Local regulations concerning the disposal of

            this product.









 Section 6 : Storage and Handling Precautions



      Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber

              gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or

              NIOSH/MSHA approved respirator is recommended.

      Storage and Handling: This product should be stored at room temperature. It should be kept in a tightly

              closed container. This product should be handled only by qualified experienced professionals.

              Wash thoroughly after handling this material.









Section 7 : Physical Data



      Appearance: Solid                                              Odor: Not Available

      Molecular Weight: 214.2                                        Taste: Not Available

      Boiling Point: Not Available                                   Melting Point: Not Available

      Solubility: Water                                              Vapor Density: Not Available

      Specific Gravity: Not Available                                Vapor Pressure: Not Available

      Volatility: Not Available

Section 8 : Stability and Reactivity Data



         Stability: This material is stable if stored as directed

         Conditions to Avoid: None known

         Incompatibles: Strong oxidizing agents







Section 9 : Toxicity Data



         RTECS#:         TE6491000



         Oral LD50:                   Mouse : 842 mg/kg                     Rat : 826 mg/kg

                                      Monkey : >10000 mg/kg                 Guinea Pig : 635 mg/kg



         I.P. LD50:                   Rat : 418 mg/kg                       Mouse : 321 mg/kg

                                      Guinea Pig : 407 mg/kg



         I.M. LD50:                   Rat : 396 mg/kg                       Mouse : 514 mg/kg



         I.V. LD50:                   Mouse : 557 mg/kg









Section 10 : Ecological Data



         Ecotoxicological Information: None Available







The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of

safe use of this material rests entirely with the user.





Emergency Contact:



BIOMOL International L.P.

5120 Butler Pike

Plymouth Meeting, PA 19462 USA



(610) 941-0430







Last Revised : 12/3/04