MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 1: PRODUCT and COMPANY IDENTIFICATION
PRODUCT NAME: CATALOG #
Direct Enzymatic HbA1c Assay DZ168A
Lysis Buffer 60211
Reagent R1a 60200
Reagent R1b 60199
Reagent R1b 60201
Supplier: Diazyme Laboratories Manufacturer: Diazyme Laboratories Authorized Representative: MDSS GmbH
12889 Gregg Court 12889 Gregg Court Schiffgraben 41
Poway, CA 92064, USA Poway, CA 92064, USA 30175 Hannover
858-455-4754 858-455-4754 Germany
In case of Emergency: Please call local authorities. Diazyme Laboratories (858-455-4754) will assist with any questions on product safety.
Intended Use: Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
SECTION 2: HAZARDOUS INGREDIENTS
Product Ingredient Amount CAS # EINECS # Symbols R-Phrase S-Phrase
Lysis Buffer Triton X-100 2% 9002-93-1 None Xn-N 22-41-51/53 26-36/39-61
Lysis Buffer CHES 2% 103-47-9 None Xi 36 26
Reagent 1a None None None None None None None
Reagent 1b None None None None None None None
Reagent 2 D-Trehalose anhydrous 5% 99-20-7 202-739-6 Xi 38 26,37/39
NOTE: Physical and health hazard information on reagent mixtures has not been determined. Any physical and health information noted is based on 1) evaluation of
data for the pure ingredients from the chemical vendors, and 2) concentration of ingredients as packaged.
SECTION 3: HAZARD INDENTIFICATION
Eye: May cause eye irritation.
CHES:
Skin: Causes moderate skin irritation. May be harmful if absorbed
EMERGENCY OVERVIEW through the skin.
Irritating to eyes, respiratory system and skin.The toxicological properties of Ingestion: May cause irritation of the digestive tract. Expected to be a
this material have not been fully investigated.Hygroscopic (absorbs moisture low ingestion hazard.
from the air). Inhalation: May cause respiratory tract irritation. May be harmful if
inhaled.
Potential Health Effects
Chronic: No information available.
Eye: Causes eye irritation.
Skin: Possible skin irritation.
Ingestion: May cause irritation of the digestive tract. Expected to be a
TRITON X-100:
low ingestion hazard.
EMERGENCY OVERVIEW
Inhalation: May cause respiratory tract irritation. May be harmful if
Irritating to skin.
inhaled.
Chronic: Not known. Potential Health Effects
Eye: Risk of serious damage to eyes.
TREHALOSE: Skin: No information available.
EMERGENCY OVERVIEW
Ingestion: Harmful if swallowed.
Irritating to skin. Inhalation: No information available.
Chronic: No information available.
Potential Health Effects
MSDS 1029 Rev C Page 1 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 4: FIRST AID MEASURES
CHES: Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immedi-
Eyes: Flush eyes with plenty of water for at least 15 minutes,
ately. If not breathing, give artificial respiration. If
occasionally lifting the upper and lower eyelids. Get
breathing is difficult, give oxygen. Get medical aid.
medical aid immediately.
Notes to Physician: Treat symptomatically and supportively.
Skin: Flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Wash
clothing before reuse. TRITON X-100:
Ingestion: Wash mouth out with water. Get medical aid. Eyes: Flush eyes with plenty of water for at least 15 minutes,
Inhalation: Remove from exposure and move to fresh air immedi- occasionally lifting the upper and lower eyelids. Get
ately. If breathing is difficult, give oxygen. Get medical medical aid.
aid. Skin: Flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes.
TREHALOSE:
Ingestion: Get medical aid. Wash mouth out with water.
Eyes: Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get Inhalation: Remove from exposure and move to fresh air immedi-
medical aid. ately. If breathing is difficult, give oxygen. Get medical
aid.
Skin: Get medical aid. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing Notes to Physician: Treat symptomatically and supportively.
and shoes.
SECTION 5: FIRE FIGHTING MEASURES
combustion. Dangerous fire hazard in the form of
CHES:
dust when exposed to heat or flame.
General Information: As in any fire, wear a self-contained breathing
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or
apparatus in pressure-demand, MSHA/NIOSH
chemical foam.
(approved or equivalent), and full protective gear.
During a fire, irritating and highly toxic gases
TRITON X-100:
may be generated by thermal decomposition or
combustion. General Information: As in any fire, wear a self-contained breathing
apparatus in pressure-demand, MSHA/NIOSH
Extinguishing Media: In case of fire, use water, dry chemical, chemical
(approved or equivalent), and full protective gear.
foam, or alcohol-resistant foam.
During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or
TREHALOSE:
combustion. Dangerous fire hazard in the form of
General Information: As in any fire, wear a self-contained breathing dust when exposed to heat or flame.
apparatus in pressure-demand, MSHA/NIOSH
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or
(approved or equivalent), and full protective gear.
chemical foam.
During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or
SECTION 6: ACCIDENTAL RELEASE MEASURES
Spills/Leaks: Vacuum or sweep up material and place into a
CHES:
suitable disposal container. Avoid generating
General Information: Use proper personal protective equipment as dusty conditions. Do not let this chemical enter
indicated in Section 8. the environment.
Spills/Leaks: Vacuum or sweep up material and place into a TRITON X-100:
suitable disposal container. Avoid generating
General Information: Use proper personal protective equipment as
dusty conditions.
indicated in Section 8.
Spills/Leaks: Absorb on sand or vermiculite and place into a
TREHALOSE:
suitable disposal container. Ventilate area. Do not
let this chemical enter the environment.
General Information: Use proper personal protective equipment as
indicated in Section 8.
MSDS 1029 Rev C Page 2 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 7: HANDLING AND STORAGE
CHES: TREHALOSE:
General Information: Use proper personal protective equipment as Handling: Wash thoroughly after handling. Remove contaminated
indicated in Section 8. clothing and wash before reuse. Avoid contact with eyes,
Spills/Leaks: Clean up spills immediately, observing precau- skin, and clothing. Avoid ingestion and inhalation.
tions in the Protective Equipment section. Sweep Storage: Store in a cool, dry place. Keep container closed when not in
up material, then place into a suitable clean, dry, use.
closed container for disposal. Avoid generating
dusty conditions. Provide ventilation.
TRITON X-100:
Handling: Do not breathe vapor. Avoid contact with eyes, skin, and
clothing. Avoid Avoid prolonged and repeated exposure.
Storage: Store in a cool, dry place. Keep container closed when not in
use.
SECTION 8: EXPOSURE CONTROLS / PERSONAL PROTECTION
CHES: Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Engineering Controls:
Skin: Wear appropriate protective gloves to prevent skin exposure.
Facilities storing or utilizing this material should be equipped with an eye-
wash facility and a safety shower. Use adequate ventilation to keep airborne Clothing: Wear appropriate protective clothing to prevent skin expo-
concentrations low. sure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR
Exposure Limits
1910.134 or European Standard EN 149. Use a
CAS# 103-47-9:
NIOSH/MSHA or European Standard EN 149 approved res-
Personal Protective Equipment pirator if exposure limits are exceeded or if irritation or other
Eyes: Wear appropriate protective eyeglasses or chemical safety symptoms are experienced.
goggles as described by OSHA's eye and face protection
regulations in 29 CFR 1910.133 or European Standard
EN166. TRITON X-100:
Skin: Wear appropriate protective gloves to prevent skin exposure.
Engineering Controls:
Clothing: Wear appropriate protective clothing to prevent skin expo-
Facilities storing or utilizing this material should be equipped with an eye-
sure.
wash facility and a safety shower. Use adequate ventilation to keep airborne
Respirators: A respiratory protection program that meets OSHA's 29 CFR concentrations low.
1910.134 and ANSI Z88.2 requirements or European Stan-
Exposure Limits
dard EN 149 must be followed whenever workplace condi-
1ppm (ACGIH, TLV).
tions warrant respirator use.
Personal Protective Equipment
Eyes: Wear chemical splash goggles.
TREHALOSE:
Skin: Wear appropriate protective gloves to prevent skin exposure.
Engineering Controls:
Clothing: Wear appropriate protective clothing to prevent skin expo-
Facilities storing or utilizing this material should be equipped with an eye- sure.
wash facility and a safety shower. Use adequate ventilation to keep airborne
Respirators: Follow the OSHA respirator regulations found in 29 CFR
concentrations low.
1910.134 or European Standard EN 149. Use a
Exposure Limits NIOSH/MSHA or European Standard EN 149 approved res-
pirator if exposure limits are exceeded or if irritation or other
CAS# 99-20-7: Not available.
symptoms are experienced.
MSDS 1029 Rev C Page 3 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Autoignition Temperature: Not available
CHES:
Flash Point: Not available
Physical State: Fine Crystals Explosion Limits: Lower: Not available
Color: White Explosion Limits: Upper: Not available
Odor: Not available Decomposition Temperature: Not available
pH: 3.0-5.0 Solubility in water: Soluble
Vapor Pressure: Not available Specific Gravity/Density: Not available
Viscosity: Not available Molecular Formula: C8H17NO3S
Boiling Point: Not available Molecular Weight: 209.29
Freezing/Melting Point: Not available
Auto ignition Temperature: Not available.
TRITON X-100:
Flash Point: Not available
Explosion Limits: Lower: Not available Physical State: Clear Liquid
Explosion Limits: Upper: Not available Color: Faintly yellow
Decomposition Temperature: Not available Odor: Not available
Solubility in water: Moderately Soluble pH: 9.7
Specific Gravity/Density: Not available. Vapor Pressure: <1 mmHG
Molecular Formula: (CH2OH)3CNH2 Viscosity: Not available
Molecular Weight: 121.14 Boiling Point: >200癈
Freezing/Melting Point: 6癈
TREHALOSE: Autoignition Temperature: Not available
Flash Point: 485癋 or 251癈
Physical State: Crystalline powder
Explosion Limits: Lower: Not available
Color: white to off-white
Explosion Limits: Upper: Not available
Odor: Not available
Decomposition Temperature: Not available
pH: Not available
Solubility in water: Soluble
Vapor Pressure: Not available
Specific Gravity/Density: 1.07 g/cm3
Viscosity: Not available
Molecular Formula: (C2H4O) nCl4H220
Boiling Point: Not available
Freezing/Melting Point: Not available
SECTION 10: STABILITY AND REACTIVITY
CHES: Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon diox-
Chemical Stability: Stable under normal tempera-
ide.
tures and pressures.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: Dust generation, exposure to
moist air or water.
Incompatibilities with Other Materials Strong oxidizing agents, strong
TRITON X-100:
acids.
Hazardous Decomposition Products Carbon monoxide, carbon diox- Chemical Stability: Stable under normal tempera-
ide, Notrigen oxides, sulfur ox- tures and pressures.
ides. Conditions to Avoid: Dust generation, exposure to
Hazardous Polymerization Will not occur. moist air or water.
Incompatibilities with Other Materials Strong oxidizing agents, strong
TREHALOSE: acids.
Hazardous Decomposition Products Carbon monoxide, carbon diox-
Chemical Stability: Hygroscopic: absorbs moisture
ide.
or water from the air.
Hazardous Polymerization Will not occur.
Conditions to Avoid: Incompatible materials, exposure
to moist air or water.
MSDS 1029 Rev C Page 4 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
SECTION 11: TOXICOLOGICAL INFORMATION
CHES: Carcinogenicity: D-Trehalose anhydrous - Not listed as a carcinogen by
ACGIH, IARC, NTP, or CA Prop 65.
RTECS#: CAS# 77-86-1: TY2900000
Other: The toxicological properties have not been fully inves-
LD50/LC50: RTECS:
tigated. See actual entry in RTECS for complete infor-
CAS# 103-47-9: Not known
mation.
Carcinogenicity: Not listed as a carcinogen by ACGIH, IARC, NTP, or
TRITON X-100:
CA Prop 65.
RTECS#: MD0907700
Other: The toxicological properties have not been fully inves-
LD50/LC50: Oral rat female LD50 = 707 mg/kg. Oral rat male LD50
tigated. See actual entry in RTECS for complete in-
= 500 mg/kg
formation.
Carcinogenicity: Not listed as a carcinogen by ACGIH, IARC, NTP, or
CA Prop 65.
TREHALOSE:
Other: Complete toxicological properties may have not been
RTECS#: CAS# 99-20-7: None listed
fully investigated. See actual entry in RTECS for com-
LD50/LC50: RTECS: Not available. plete information.
SECTION 12: ECOLOGICAL INFORMATION
CHES:
TRITON X-100:
Other: No information available.
Other: Do not empty into drains.
TREHALOSE:
Other: Do not empty into drains.
SECTION 13: DISPOSAL CONSIDERATIONS
CHES: TREHALOSE:
Dispose of in a manner consistent with federal, state, and local regulations. Dispose of in a manner consistent with federal, state, and local regulations.
TRITON X-100:
Dispose of in a manner consistent with federal, state, and local regulations.
SECTION 14: TRANSPORTATION INFORMATION
CHES, TREHALOSE: TRITON X-100:
IATA IMO IATA IMO
RID/ADR RID/ADR
Shipping Name: Not regulated. Not regulated. Not Shipping Name: Regulated. Not regulated. Not
regulated. regulated.
Hazard Class: 9
Hazard Class:
UN Number: 3082
UN Number:
Packing Group: III
Packing Group:
SECTION 15: REGULATORY INFORMATION
Not listed on SARA
CHES:
TREHALOSE:
European/International Regulations
European Labeling in Accordance with EC Directives European/International Regulations
Hazard Symbols: Xi European Labeling in Accordance with EC Directives
Risk Phrases: Hazard Symbols: XI
R 36 Risk Phrases:
Safety Phrases: R 38 Irritating to skin.
S 26 Safety Phrases:
WGK (Water Danger/Protection) S 26 In case of contact with eyes, rinse immediately with
plenty of water and seek medical advice.
Not available
S 37/39 Wear suitable gloves and eye/face protection.
Canada
WGK (Water Danger/Protection)
Is listed on Canada's NDSL List
Not available
US Federal
MSDS 1029 Rev C Page 5 of 6
MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC and ISO 11014-1 Responsible Name: Diazyme Administration
Effective 08/06/08
R 22-41-51/53
Canada
Safety Phrases:
Is listed on Canada's DSL List
S 26-36/39-61
US Federal
WGK (Water Danger/Protection)
Is listed on the TSCA Inventory.
Not available
Canada
TRITON X-100: Listed on Canada's DSL List
European/International Regulations US Federal
European Labeling in Accordance with EC Directives TSCA Inventory Item: Yes
Hazard Symbols: Xn-N
Risk Phrases:
SECTION 16: OTHER INFORMATION
PREPARED BY: Diazyme Administration
PHONE NO: 858-455-4754
DATE PREPARED: 28 March 2007
The information provided on this Material Safety Data Sheet is provided in the interest of promoting safe handling of the material. While this information is believed to
be correct, Diazyme makes no warranty in respect to any of the information disclosed. Observe all federal, provincial, state and local laws concerning health and envi-
ronmental pollution.
MSDS 1029 Rev C Page 6 of 6
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