Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Replaces version GHB/December 2004
Product name GLYPHOSATE 360 g/l SL
Page 1 of 9
SAFETY DATA SHEET
GLYPHOSATE 360 g/l SL
Table of contents
1. Identification of the substance/preparation 9. Physical and chemical properties
and of the company/undertaking 10. Stability and reactivity
2. Composition/information on ingredients 11. Toxicological information
3. Hazards identification 12. Ecological information
4. First aid measures 13. Disposal considerations
14.
5. Fire-fighting measures Transport information
6. Accidental release measures 15. Regulatory information
7. Handling and storage 16. Other information
8. Exposure controls/personal protection
Revision: Sections containing a revision or new information are marked with a .
IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING
1.
N GLYPHOSATE 360 g/l SL
Product name
Intended use Herbicide
CHEMINOVA A/S
Manufacturer
Dangerous P.O. Box 9
for the
DK-7620 Lemvig
environment
Denmark
Emergency (+45) 97 83 53 53
telephone no.
2. COMPOSITION/INFORMATION ON INGREDIENTS
2.1. ACTIVE INGREDIENT ............. Glyphosate, in the form of its isopropylamine salt
Glyphosate
CAS name ..................................... Glycine, N-(phosphonomethyl)-
CAS no. ........................................ 1071-83-6
IUPAC name ................................. N-(Phosphonomethyl)glycine
ISO name/EU name ....................... Glyphosate
EC no. (EINECS no.) ................... 213-997-4
EU index no. ................................ 607-315-00-8
EU classification of the substance Xi;R41 N;R51/53; see section 16.
Empirical formula ........................ C3H8NO5P
Molecular weight ......................... 169.07
O
Structural formula .........................
HOOCCH2NHCH2 P OH
OH
Glyphosate isopropylamine salt
CAS name ..................................... Glycine, N-(phosphonomethyl)-, compd. with 2-propanamine (1:1)
CAS no. ........................................ 38641-94-0
IUPAC name ................................. ?br>
EU name ........................................ N-(phosphonomethyl)glycine, compound with 2-propylamine (1:1)
Common name .............................. Glyphosate isopropylamine salt
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 2 of 9
Other name(s) ................................ Glyphosate-isopropylammonium
EC no. (EINECS no.) ................... 254-056-8
EU index no. ................................ 015-184-00-8
EU classification of the ingredient N;R51/53; see section 16.
Empirical formula ........................ C6H17N2O5P
Molecular weight ......................... 228.19
O
Structural formula .........................
+
HOOCCH2NHCH2 P OH H3N CH(CH3)2
O
2.2. TYPICAL CONTENT
Glyphosate, as isopropylamine salt*) .................. 42.0% by weight
Active ingredient ....................
Inert ingredients ...................... Surfactant, water, etc. .......................................... 58.0% by weight
*) The product contains 486 g/l of the active ingredient glyphosate
...........................................................................................isopropylamine
salt, equivalent to 360 g/l of the free acid glyphosate.
Reportable ingredient ............... Tallow alkyl amine ethoxylate ............................ 9% by weight
CAS no.: 61791-26-2
EU classification: Xn;R22 Xi;R41 N;R51/53; see section 16.
3. HAZARDS IDENTIFICATION
3.1. CLASSIFICATION
EU classification of the product .... N;R51/53; see 15.1.
(according to 1999/45/EC as amended)
WHO classification ....................... None. Unlikely to present acute hazard in normal use.
3.2. Health hazards (acute and chronic) The irritating properties of the product are the most serious health
hazard for all possible routes of exposure.
Eye contact.......................... The product may cause moderate to severe but temporary irritation
to the eyes.
Skin contact......................... The product may be slightly irritating to skin, especially on
prolonged contact. It is not considered to be harmful by skin
contact.
Ingestion ............................. The product can have irritating effects to the upper digestive tract.
It may be slightly harmful if swallowed.
Inhalation ............................ The product may be slightly harmful if inhaled. The most serious
effect of inhalation may be irritation of the respiratory tract,
resulting in coughing and sneezing.
3.3. Environmental hazards ................. The product is a herbicide and is therefore expected to be harmful
to all green plants. See section 12.
4. FIRST AID MEASURES
4.1. Signs and symptoms of exposure .. Primarily irritation. See 3.2. and section 11.
4.2. Emergency and first aid procedures Immediate medical attention is required in case of eye contact.
Obtain medical attention or advice as indicated for other exposure.
If in eyes ............................... Immediately flush with plenty of water or eyewash solution,
occasionally opening eyelids, until no evidence of chemical
remains. Remove contact lenses after a few minutes and flush
again. Get medical attention immediately.
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 3 of 9
If on skin ............................... Remove contaminated clothing and shoes. Wash with plenty of
water and soap. Get medical attention if irritation develops.
If swallowed ......................... The product may cause gastrointestinal tract irritation. Immediately
dilute by drinking milk. If not available, drink water. Do not induce
vomiting. If vomiting occurs, drink fluids again. Call a doctor or
get medical attention.
If inhaled ............................... If experiencing any discomfort, immediately remove to fresh air
and obtain medical advice if discomfort does not disappear.
4.3. Note to physician ........................... The irritating effects of this product can be treated as usual against
effects of acids or acid fumes. Probable mucosal damage may
contraindicate the use of gastric lavage.
5. FIRE-FIGHTING MEASURES
5.1. Extinguishing media and procedure Dry chemical or carbon dioxide for small fires. Water spray or
foam for large fires.
Use water spray to keep fire-exposed containers cool. Approach
fire from upwind to avoid hazardous vapours and toxic
decomposition products. Fight fire from protected location or
maximum possible distance. Avoid heavy hose streams. Dike area
to prevent water runoff. Firemen should wear self-contained
breathing apparatus and protective clothing.
5.2. Hazardous decomposition or The essential breakdown products are carbon monoxide, carbon
byproducts in a fire dioxide, phosphorus pentoxide and nitrogen oxides.
5.3. Unusual fire and explosion hazards The product does not present any unusual fire hazard. It is
advisable for firemen to avoid direct contact with the product such
as splashing.
6. ACCIDENTAL RELEASE MEASURES
6.1. Personal protection ....................... Observe all protection and safety precautions. Depending on the
magnitude of the spill this may mean wearing eye protection,
chemical resistant clothing, gloves and boots when cleaning up
spills. See section 8, Personal protection. Personal exposure by
splashing must be avoided.
6.2. Steps to be taken in case of spill ... It is recommended to have a predetermined plan for the handling of
spills.
Stop the source of the spill immediately if safe to do so. Contain the
spill to prevent any further contamination of surface, soil or water.
Spills on the floor or other impervious surface should be contained
or diked and then absorbed onto an absorptive material such as
hydrated lime, universal absorbent, attapulgite, bentonite or other
absorbent clays. Collect the contaminated absorbent and transfer to
suitable containers (not metal). Thoroughly scrub the area with a
strong industrial detergent and rinse with water. Washings must be
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 4 of 9
prevented from entering surface water drains.
Large spills which soak into the ground should be dug up and
transferred to suitable containers.
Spills in water should be contained as much as possible by isolation
of the contaminated water. The contaminated water must be
collected and removed for treatment or disposal. Uncontrolled
discharge into water courses must be alerted to the appropriate
regulatory body.
The used containers should be properly closed and labelled. Refer
to section 13 for disposal.
7. HANDLING AND STORAGE
7.1. Precautions to be taken in handling In an industrial environment it is recommended to avoid all
personal contact with the product, preferably by use of closed
systems and remote system control. Otherwise adequate ventilation
or local exhaust ventilation is required. The exhaust gases should be
filtered or treated otherwise. For personal protection, see section 8.
For its use as a pesticide, first look for precautions and personal
protection measures on the officially approved label on the
packaging or for other official guidance or policy in force. If these
are lacking, see section 8. The precautions of section 8 are
primarily meant for handling of the undiluted product and for
preparing the spray solution, but can be recommended for spraying
as well.
The product or its spray solutions should be mixed, stored or
applied using only stainless steel, aluminium, fiberglass, plastic or
plastic-lined containers. See 10.3.
Do not apply directly to water, to areas where surface water is
present or to intertidal areas below the mean high water mark.
Do not contaminate water when disposing of equipment
washwaters.
7.2. Precautions to be taken in storing The product is stable under normal conditions of warehouse
storage. Store in closed, labelled containers.
Do not contaminate water, foodstuffs, feed or seed by storage or
disposal.
7.3. Specific use ................................... This product is a registered pesticide, which may only be used for
the applications it is registered for, in accordance with a label
approved by the regulatory authorities.
7.4. Fire and explosion precautions ..... ?br>
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1. Exposure limit values .................... To our knowledge, personal exposure limits have not been
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 5 of 9
established for glyphosate or any other component in this product.
However, exposure limit values defined by local regulations may
exist and must be observed.
8.2. Personal protection ........................ When used in a closed system, personal protection equipment will
not be required. The following is meant for other situations, when
the use of a closed system is not possible, or when it is necessary to
open the system. Consider the need to render equipment or piping
systems nonhazardous before opening.
Respiratory protection ............ The product is not likely to present an airborne exposure concern
during normal handling. In the event of an accidental discharge of
the material which produces a heavy vapour or mist, workers
should put on officially approved respiratory protection equipment
with a universal filter type including particle filter.
Protective gloves ..................... Wear heavy duty, natural rubber gloves. The breakthrough times of
gloves for glyphosate are unknown, but it is expected that they will
give adequate protection because of the low dermal toxicity of the
product. It is recommended to limit the work to be done manually.
Eye protection ......................... Wear goggles, safety glasses or face shield. It is recommended to
have an eye wash fountain immediately available in the work area
when there is a potential for eye contact.
Skin protection ........................ Wear appropriate protective clothing to prevent skin contact.
Applicators and other handlers must wear long-sleeved shirt, long
pants, shoes plus socks and protective eyewear.
8.3. Work/hygienic practices ................ Avoid contact with eyes, skin or clothing. Avoid breathing vapour
or spray mist. Before removing gloves, wash them with water and
soap. Wash thoroughly with water and soap after handling. Remove
contaminated clothing immediately and wash before reuse.
After work, take off all work clothes and shoes. Shower, using
water and soap. Wear only clean clothes when leaving job. Do not
wear contaminated clothing.
8.4. Environmental exposure controls .. See section 13.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1. Physical state ................................ Clear, viscous solution
9.2. Colour ........................................... Yellow
9.3. Odour ........................................... Practically odourless to slight amine-like odour
9.4. Melting point ................................. < 0癈
9.5. Boiling point ................................. 113癈
9.6. Tap density .................................... 1.165 g/ml at 20癈
For glyphosate free acid: 1.75 x 10-7 mm Hg (1.31 x 10-5 Pa) at 25癈
9.7. Vapour pressure ............................
9.8. Viscosity ........................................ 43 cS at 20癈, 18 cS at 40癈 (kinematic viscosity)
9.9. Surface tension .............................. 39 mN/m at 20癈 (1% solution in water)
9.10. Solubility in water ......................... The product is miscible with water.
Solubility of glyphosate free acid: 10.5 g/l at 20癈.
P = 4.5 x 10-4; Log P = -3.3 (glyphosate free acid)
9.11. Partition coefficient n-octanol/water
9.12. pH ................................................. 4.5 at 20癈 (1% solution in water)
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 6 of 9
9.13. Flash point .................................... > 113癈
9.14. Autoignition temperature ............. Not available
9.15. Explosivity .................................... Not explosive
9.16. Oxidising properties ...................... Not oxidising
10. STABILITY AND REACTIVITY
10.1. Chemical stability .......................... The product is stable at ambient temperatures.
10.2. Hazardous decomposition or
byproducts ..................................... None (however, see 5.2.)
10.3. Materials to avoid ......................... Do not mix, store or apply this product or spray solutions of
this product in galvanised or unlined steel (except stainless
steel) containers or spray tanks.
This product or spray solutions of this product react with such
containers and tanks to produce hydrogen gas which may form a
highly combustible gas mixture with air. This gas mixture could
flash or explode, causing serious personal injury, if ignited by open
flame, spark, welders torch, lighted cigarette or other ignition
source.
The product can react with caustic (basic) materials in an acid-base
chemical neutralisation reaction which may be hazardous because
of heat release.
11. TOXICOLOGICAL INFORMATION
11.1. Acute toxicity ................................ The product is practically non-toxic. However, it should always be
treated with the usual care of handling chemicals. It may be slightly
harmful if swallowed. No significant adverse health effects are
expected to develop if only small amounts (less than a mouthful)
are swallowed. Ingestion of similar formulations has been reported
to produce gastrointestinal discomfort with nausea, vomiting and
diarrhoea. Oral ingestion of large quantities of one similar product
has been reported to result in hypotension and lung oedema.
The acute toxicity of the product is measured to be:
Route(s) of entry - Ingestion LD50, oral, rat: > 5000 mg/kg
- Skin LD50, dermal, rat: > 2000 mg/kg
- Inhalation LC50, inhalation, rat: > 4.86 mg/l/4 h
(maximally obtainable concentration; no signs of toxicity at this
concentration)
11.2. Irritancy ......................................... The product is moderately irritating to eyes and mildly irritating to
skin. It can have irritating effects on the upper digestive and
respiratory tract. Repeated and prolonged exposure to high
exposure levels may result in serious irritation.
11.3. Allergic sensitisation .................... No sensitising properties to guinea pigs are found in the
Magnusson-Kligmann Maximisation test. No allergic effects on
humans have been reported.
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 7 of 9
11.4. Chronic toxicity ............................. In long-term studies, body weight and liver weight changes were
noted in rats at exposure levels of 60-100 mg glyphosate/kg
bw/day. There were no signs of toxicity at any level, including the
highest exposure level of 4800 mg glyphosate/kg bw/day.
11.5. Carcinogenicity ............................ No indications of carcinogenic effects are found. US-EPA has
classified glyphosate in category E (evidence of non-
carcinogenicity for humans).
11.6. Reproductive effects ..................... A number of multigeneration studies did not indicate a specific
hazard of glyphosate for reproduction. The effects seen at very high
doses were the same as for chronic toxicity.
11.7. Teratogenicity .............................. Glyphosate does not cause teratogenicity. Only at very high doses
(4800 mg/kg bw/day) adverse effects on offspring were noted, such
as reduced weight of fetuses.
11.8. Mutagenicity ................................ Glyphosate was examined for mutagenicity in a wide range of tests
covering all relevant endpoints in vitro as well as in vivo. Against
the background of this large amount of data, it can be concluded
that glyphosate does not exhibit a mutagenic risk.
11.9. Cholinesterase inhibition ............... Glyphosate has no inhibitory effect on cholinesterase and is not
neurotoxic. Thus, the properties of glyphosate cannot be compared
to those of other organophosphate pesticides.
12. ECOLOGICAL INFORMATION
12.1. Ecotoxicity .................................... The product is a herbicide and therefore expected to be toxic to all
green plants. The product is harmful to fish and aquatic
invertebrates. It is considered as less harmful to birds and soil
micro- and macroorganisms.
The ecotoxicity of the product is measured to be:
- Fish Rainbow trout (Salmo gairdneri) .................. 96 h-LC50: 18.6 mg/l (static)
21-day NOEC: 0.43-0.81 mg/l
Bluegill sunfish (Lepomis macrochirus) ....... 96 h-LC50: 11.9 mg/l (static)
- Invertebrates Daphnids (Daphnia magna) .......................... 48 h-EC50: 21.6 mg/l
21-day NOEC: 1.5 mg/l
- Algae Green algae (Scenedesmus subspicatus) ....... 72-h IC50: 17.4 mg/l
(Selenastrum capricornutum) ..... 72-h IC50: 2.0 mg/l
- Plants Duckweed (Lemna gibba) ............................. 7-day EC50: 27 mg/l
- Earthworms Eisinia foetida foetida .................................. 14-day LC50: > 1000 mg/kg dry soil
- Birds Japanese quail (Coturnix japonica) ............... LD50: 1900 mg/kg
5-day dietary LD50: > 5000 ppm in feed
Honey bees (Apis mellifera) .......................... 48-h LD50, acute oral: > 100 礸/bee
- Bees
24-h LD50, topical: > 20 礸/bee
- Bacteria Activated sludge ........................................... IC50: > 100 mg/kg
12.2. Mobility ......................................... In the environment glyphosate is not mobile, but is rapidly
deactivated by adsorption to clay particles. Glyphosate binds
strongly to soil.
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 8 of 9
12.3. Persistence and degradability ........ Glyphosate is not readily biodegradable. It undergoes slow
degradation in the environment and in waste water treatment plants.
No adverse effects are found at concentrations up to 100 mg/l in
waste water treatment plants. Degradation is mainly
microbiological and aerobic, but anaerobic degradation does also
occur.
Degradation half-lives in the environment vary much with
circumstances, but are usually around 3-30 days in aerobic soil and
water.
12.4. Bioaccumulative potential ............. Glyphosate is not expected to bioaccumulate. Several studies have
been done on bioaccumulation of glyphosate, both in marine and
freshwater systems. Only low bioaccumulation factors were found.
13. DISPOSAL CONSIDERATIONS
13.1. Waste disposal method ................. Material that cannot be reused or chemically reprocessed should be
disposed of in a landfill approved for pesticide disposal. Other
possible methods of disposal are controlled incineration with flue
gas scrubbing or removal to a licensed chemical destruction plant.
Contact appropriate state agency when considering a land spreading
disposal option.
Do not contaminate water, foodstuffs, feed or seed by storage or
disposal.
13.2. Packaging/container disposal ....... Emptied containers may retain vapour and product residue. Observe
all labelled safeguards until container is cleaned or destroyed. DO
NOT CUT OR WELD ON OR NEAR THIS CONTAINER.
Triple rinse container (or equivalent) and offer for recycling or
reconditioning. The packaging can also be punctured to make it
unusable for other purposes and then be disposed of in a sanitary
landfill. Other methods of disposal are controlled incineration with
flue gas scrubbing or, if allowed by state and local regulations, by
burning. If burned, stay out of smoke.
Disposal of waste and packagings must always be in accordance
with all applicable local regulations.
14. TRANSPORT INFORMATION
ADR/RID CLASSIFICATION
Proper shipping name .................... Environmentally Hazardous Substance, Liquid, N.O.S. (Glyphosate
isopropylamine salt)
Class .............................................. 9
UN no. ........................................... 3082
Packaging group ............................ III
IMDG CLASSIFICATION
Not classified as hazardous material for transport by ship
Safety data sheet according to 91/155/EEC as amended.
Cheminova A/S Phone (+45) 96 90 96 90
P.O. Box 9 Fax (+45) 96 90 96 91
DK-7620 Lemvig www.cheminova.com
Denmark CVR-No. DK 12 76 00 43
GHB/May 2005
Product no. 45A/4510
Product name GLYPHOSATE 360 g/l SL
Page 9 of 9
IATA/ICAO CLASSIFICATION
Not classified as hazardous material for transport by air
15. REGULATORY INFORMATION
15.1. IN THE EU
Classification and labelling
(according to 1999/45/EC as amended):
Hazard symbol ................... N
Dangerous
for the
environment
Contains ............................. Glyphosate isopropylamine salt
R-phrases ........................... R51/53: Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S-phrases ............................ S60-61: This material and its container must be disposed of as
hazardous waste. Avoid release to the environment. Refer to special
instructions/safety data sheets.
Other mentions ................... To avoid risks to man and the environment, comply with the
instructions of use.
15.2. Regulatory status ........................... All components in this product are covered by EU chemical
legistation.
16. OTHER INFORMATION
Used R-phrases ............................. R22 Harmful if swallowed.
R41 Risk of serious damage to eyes.
R51/53 Toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
The information provided in this safety data sheet is believed to be accurate and reliable, but uses of the
product may vary and situations unforeseen by Cheminova A/S may exist. The user of the material has to
check the validity of the information under local circumstances.
Safety data sheet according to 91/155/EEC as amended.
|