SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 03/APR/2005
Date Updated: 14/MAR/2004
Version 1.3
According to 91/155/EEC
1 - Product and Company Information
Product Name L-LEUCINE
Product Number 61819
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
L(+)-LEUCINE 61-90-5 200-522-0 None
Formula C6H13NO2
Molecular Weight 131.18 AMU
Synonyms alpha-Aminoisocaproic acid *
L-alpha-Aminoisocaproic acid *
2-Amino-4-methylpentanoic acid *
(S)-2-Amino-4-methylpentanoic acid *
alpha-Amino-gamma-methylvaleric acid *
(S)-2-Amino-4-methylvaleric acid * Leu * Leucin
(German) * Leucine * L-(+)-Leucine * (S)-Leucine
* Norvaline, 4-methyl- * L-Norvaline, 4-methyl-
* Pentanoic acid, 2-amino-4-methyl-, (S)- *
Valeric acid, 2-amino-4-methyl-
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 300 掳C
Flash Point N/A
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Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1M HCl 1M, 20掳C complete,
colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: OH2850000
ACUTE TOXICITY
LD50
Intraperitoneal
Rat
5379 MG/KG
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Nutritional and
Gross Metabolic:Changes in:Body temperature decrease.
SIGNS AND SYMPTOMS OF EXPOSURE
The levorotary (l) forms of leucine, isoleucine, and valine have
been found to have tumor-promoting activity for bladder
carcinomas. Science 231, 843, 21 February 1986. To the best of
our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
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CHRONIC EXPOSURE - MUTAGEN
Human
10 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 90 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Specific Developmental Abnormalities: Body wall.
Species: Rat
Dose: 90 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
Species: Rat
Dose: 60 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Effects
on Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Species: Rat
Dose: 60 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 138 GM/KG
Route of Application: Oral
Exposure Time: (5-15D PREG)
Result: Effects on Fertility: Other measures of fertility
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rat
Dose: 90 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-6D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Other developmental
abnormalities.
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EC.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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