SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/MAR/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 3-(3,4-DIHYDROXYPHENYL)-L-ALANINE
Product Number 37830
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
3,4-DIHYDROXY-L-PHENYLALANINE 59-92-7 200-445-2 None
Formula C9H11NO4
Molecular Weight 197.19 AMU
Synonyms Alanine, 3-(3,4-dihydroxyphenyl)-, (-)- *
2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid *
Bendopa * Biodopa * Brocadopa * Cerepap *
Cidandopa * DA * Deadopa *
Dihydroxy-L-phenylalanine *
L-Dihydroxyphenylalanine *
beta-(3,4-Dihydroxyphenyl)-alpha-alanine *
L-alpha-Dihydroxyphenylalanine *
L-beta-(3,4-Dihydroxyphenyl)alanine *
L-3,4-Dihydroxyphenylalanine *
L-3,4-Dihydroxyphenyl-alpha-alanine *
beta-(3,4-Dihydroxyphenyl)-L-alanine *
3-(3,4-Dihydroxyphenyl)-L-alanine *
(-)-3,4-Dihydroxyphenylalanine *
3,4-Dihydroxyphenyl-L-alanine *
3,4-Dihydroxy-L-phenylalanine * DOPA * L-DOPA *
Dopaflex * Dopal * Dopaidan * Dopal-fher *
Dopalina * Dopar * Doparkine * Doparl * Dopasol
* Dopaston * Dopastral * Doprin * Eldopal *
Eldopatec * Eurodopa * Helfo DOPA *
L-o-Hydroxytyrosine * 3-Hydroxy-L-tyrosine *
Insulamina * Larodopa * Levodopa * Levopa *
Maipedopa * Parda * Pardopa * Ro 4-6316 *
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Irritating to eyes, respiratory system and
skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Air and light sensitive.
8 - Exposure Controls / Personal Protection
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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 276 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light. Air.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: AY5600000
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ACUTE TOXICITY
LD50
Oral
Rat
1780 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Ataxia.
Behavioral:Aggression.
LD50
Intraperitoneal
Rat
624 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Other. Behavioral:Excitement. Skin and Appendages:
Other: Hair.
LD50
Subcutaneous
Rat
2 GM/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Gastrointestinal:Changes in structure or function of salivary
glands. Lungs, Thorax, or Respiration:Other changes.
LD50
Intravenous
Rat
>100 MG/KG
LD50
Oral
Mouse
2363 mg/kg
Remarks: Behavioral:Excitement.
LD50
Intraperitoneal
Mouse
588 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Somnolence (general depressed
activity). Lungs, Thorax, or Respiration:Other changes.
LD50
Subcutaneous
Mouse
4449 MG/KG
Remarks: Peripheral Nerve and Sensation:Local anesthetic.
Behavioral:Convulsions or effect on seizure threshold.
Gastrointestinal:Changes in structure or function of salivary
glands.
LD50
Intravenous
Mouse
450 MG/KG
LD50
Oral
Rabbit
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609 mg/kg
LD50
Oral
Bird (wild)
100 mg/kg
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, headache, and vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Heart.
CHRONIC EXPOSURE - CARCINOGEN
Man
Route of Application: Oral
Exposure Time: 1.5Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors.
CHRONIC EXPOSURE - MUTAGEN
Human
39400 UG/L
Cell Type: Embryo
Micronucleus test
Human
3 MMOL/L
Cell Type: fibroblast
DNA damage
Human
3 MMOL/L
Cell Type: Other cell types
DNA damage
Human
3 MMOL/L
Cell Type: fibroblast
DNA inhibition
Human
3 MMOL/L
Cell Type: Other cell types
DNA inhibition
Human
3 MMOL/L
Cell Type: fibroblast
Other mutation test systems
Human
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3 MMOL/L
Cell Type: Other cell types
Other mutation test systems
Rat
25 UMOL/L
Cell Type: lung
DNA damage
Mouse
3800 NMOL/L
Cell Type: Other cell types
DNA inhibition
Mouse
100 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
98500 UG/L
Cell Type: lung
Micronucleus test
Hamster
100 UMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (1-5D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 6600 MG/KG
Route of Application: Oral
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 700 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-7D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Mouse
Dose: 4800 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 900 MG/KG
Route of Application: Oral
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Exposure Time: (7-12D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Newborn: Physical.
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 1200 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7-12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 2250 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 22 GM/KG
Route of Application: Oral
Exposure Time: (1-22D PREG)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Species: Rat
Dose: 3600 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Newborn: Growth
statistics (e.g., reduced weight gain).
Species: Rat
Dose: 480 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 4500 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (15D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
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Species: Mouse
Dose: 5 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Mouse
Dose: 2400 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Mouse
Dose: 600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7-12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 36/37/38
Harmful if swallowed. Irritating to eyes, respiratory system
and skin.
S-PHRASES: 26 36
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear suitable protective
clothing.
16 - Other Information
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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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