SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 06/FEB/2005
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name BIS[TRI-N-BUTYLTIN(IV)]OXIDE, 96%
Product Number B53383
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BIS(TRIBUTYLTIN) OXIDE 56-35-9 200-268-0 050-008-00-3
Formula C24H54OSn2
Molecular Weight 596.08 AMU
Synonyms Aceto TBTO * BioMet SRM * BioMet TBTO *
Bis-(tri-n-butylcin)oxid (Czech) *
Bis(tributyloxide) of tin *
Bis(tributylstannium) oxide *
Bis(tributylstannyl)oxide *
Bis(tributyltin)oxide * Bis(tri-n-butyltin)oxide
* Bis(tri-n-butylzinn)-oxyd (German) * BTO *
Butinox * C-Sn-9 * Di-tributyltin oxide * Drall
* ENT 24,979 * Hexabutyldistannioxan (Czech) *
Hexabutyldistannoxane * Hexabutylditin oxide *
Intercide 340A * Kyslicnik tri-n-butylcinicity
(Czech) * Lastanox F * Lastanox Q * Lastanox
Super * Lastanox T * L.S. 3394 * Mykolastanox F
* OTBE (French) * Oxybis(tributyltin) * Oxyde de
tributyletain * Stannane, tri-n-butyl-, oxide *
Stannicide A * Stannicide O * TBTO * Tin,
bis(tributyl)-, oxide * Tin, oxybis(tributyl- *
Tributyltin oxide * Vikol AF 25 * Vikol LO 25 *
ZK 21995
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful in contact with skin. Toxic if swallowed. Irritating to
eyes and skin. Toxic: danger of serious damage to health by
prolonged exposure through inhalation and if swallowed. Very toxic
to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area and keep personnel upwind.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
prolonged or repeated exposure. Do not get in eyes, on skin, on
clothing.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 0.1 mg/m3
Remarks: SKIN
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 0.05 mg/m3
0.002 ppm
Remarks: 4
Remarks: H,Y
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 0.05 mg/m3
0.0021ppm*
Remarks: C
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL TWA 0.1MG(SN)/M3
OEL STEL 0.2 mg(Sn)/m3
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 180 掳C 2 mmHg
MP/MP Range N/A
Flash Point 113 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.173 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
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Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Tin/tin oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: JN8750000
ACUTE TOXICITY
LD50
Oral
Rat
87 mg/kg
LC50
Inhalation
Rat
64 UL/M3
4H
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea.
LD50
Skin
Rat
> 300 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Skin and Appendages:Skin: After systemic exposure: Dermatitis,
other
LD50
Intraperitoneal
Rat
5 MG/KG
Remarks: Behavioral:Coma. Gastrointestinal:Alteration in gastric
secretion. Nutritional and Gross Metabolic:Changes in:Other
changes.
LD50
Oral
Mouse
55 mg/kg
LD50
Skin
Mouse
163 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
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righting reflex). Behavioral:Change in motor activity (specific
assay). Kidney, Ureter, Bladder:Other changes.
LD50
Intraperitoneal
Mouse
12500 UG/KG
Remarks: Nutritional and Gross Metabolic:Changes in:Body
temperature decrease.
LD50
Intravenous
Mouse
6 MG/KG
Remarks: Peripheral Nerve and Sensation:Spastic paralysis with
or without sensory change. Lungs, Thorax, or Respiration:Other
changes.
LD50
Skin
Rabbit
900 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Acute pulmonary edema.
Gastrointestinal:Hypermotility, diarrhea.
IRRITATION DATA
Skin
Rabbit
0.5 ml
24H
Remarks: Severe irritation effect
Eyes
Rabbit
0.05 mg
24H
Remarks: Severe irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Mild irritation effect
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Vapor or mist is
irritating to the mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
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Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Endocrine:Tumors. Endocrine:Thyroid tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Mouse
60 MG/KG
Oral
Micronucleus test
Hamster
15 UG/L
Cell Type: ovary
Other mutation test systems
Hamster
5 MG/L
Cell Type: ovary
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 150 MG/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive). Effects on Newborn: Delayed effects.
Species: Rat
Dose: 40 MG/KG
Route of Application: Oral
Exposure Time: (5D POST)
Result: Specific Developmental Abnormalities: Central nervous
system. Effects on Newborn: Delayed effects.
Species: Mouse
Dose: 400 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 50 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 324 MG/KG
Route of Application: Oral
Exposure Time: (6-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
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e.g., stunted fetus). Specific Developmental Abnormalities:
Craniofacial (including nose and tongue).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 150 MG/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Effects on
Embryo or Fetus: Fetal death.
Species: Rat
Dose: 150 MG/KG
Route of Application: Oral
Exposure Time: (6-20D PREG)
Result: Effects on Newborn: Behavioral.
Species: Mouse
Dose: 324 MG/KG
Route of Application: Oral
Exposure Time: (6-17D PREG)
Result: Maternal Effects: Other effects. Specific Developmental
Abnormalities: Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2922
Class: 8
PG: II
Proper Shipping Name: Corrosive liquid, toxic, n.o.s.
IMDG
UN#: 2922
Class: 8
PG: II
Subrisk: 6.1
Proper Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2922
Class: 8
PG: II
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Subrisk: 6.1
Proper Shipping Name: Corrosive liquid, toxic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 050-008-00-3
NOTA: A
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 21 25 36/38 48/23/25 50/53
Harmful in contact with skin. Toxic if swallowed. Irritating to
eyes and skin. Toxic: danger of serious damage to health by
prolonged exposure through inhalation and if swallowed. Very
toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
S-PHRASES: 35 36/37/39 45 60 61
This material and its container must be disposed of in a safe
way. Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
This material and its container must be disposed of as
hazardous waste. Avoid release to the environment. Refer to
special instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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