SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 11/27/2007
Date Updated: 02/05/2006
Version 1.5
Section 1 - Product and Company Information
Product Name AZOBENZENE, 96%
Product Number 150738
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
AZOBENZENE 103-33-3 No
Formula C12H10N2
Synonyms Azobenzeen (Dutch) * Azobenzide * Azobenzol *
Azobisbenzene * Azodibenzene *
Azodibenzeneazofume * Azofume * Benzeneazobenzene
* Benzene, azodi * Benzofume * Diazobenzene *
Diphenyldiazene * 1,2-Diphenyldiazene *
Diphenyldiimide * ENT 14,611 * NCI-C02926 * USAF
EK-704
RTECS Number: CN1400000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
May cause cancer. Harmful by inhalation and if swallowed. Harmful:
danger of serious damage to health by prolonged exposure if
swallowed. Possible risk of irreversible effects. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Target organ(s): Liver. Calif. Prop. 65 carcinogen. Probable
Carcinogen (US).
HMIS RATING
HEALTH: 1*
FLAMMABILITY: 1
REACTIVITY: 0
NFPA RATING
HEALTH: 1
FLAMMABILITY: 1
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
212 癋 100 癈 Method: closed cup
AUTOIGNITION TEMP
477 癈
FLAMMABILITY
N/A
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Store under inert gas.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Red
Form: Fine crystals
Property Value At Temperature or Pressure
Molecular Weight 182.23 AMU
pH N/A
BP/BP Range 293 癈 760 mmHg
MP/MP Range 66 癈
Freezing Point N/A
Vapor Pressure 1 mmHg 104 癈
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.09 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 212 癋 100 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp 477 癈
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Liver. Spleen.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer.
TOXICITY DATA
Oral
Rat
1000 mg/kg
LD50
Intraperitoneal
Mouse
500 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Species: Rat
Route of Application: Oral
Dose: 7350 MG/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Tumors.
Species: Rat
Route of Application: Subcutaneous
Dose: 17 GM/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Ear:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 300 MG/KG
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Exposure Time: 8W
Frequency: I
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors.
Species: Rat
Route of Application: Oral
Dose: 15 GM/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Tumors.
Species: Rat
Route of Application: Oral
Dose: 7280 MG/KG
Exposure Time: 2Y
Frequency: C
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
NTP CARCINOGEN LIST
Rating: Clear evidence.
Species: Rat
Route: Feed
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Species: Human
Dose: 40 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Rat
Route: Oral
Dose: 375 MG/KG
Mutation test: Micronucleus test
Species: Rat
Dose: 300 UMOL/L
Cell Type: liver
Mutation test: DNA damage
Species: Mouse
Route: Oral
Dose: 500 MG/KG
Mutation test: DNA damage
Species: Mouse
Dose: 210 MG/KG
Cell Type: E. coli
Mutation test: Host-mediated assay
Species: Hamster
Dose: 250 UG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
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Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 5 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 48 h
Value: 1.7 - 2.5 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Environmentally hazardous
substances, solid, n.o.s.
UN#: 3077
Class: 9
Packing Group: Packing Group III
Hazard Label: Class 9
PIH: Not PIH
IATA
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IATA UN Number: 3077
Hazard Class: 9
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T-N
Indication of Danger: Toxic. Dangerous for the environment.
R: 45-20/22-48/22-68-50/53
Risk Statements: May cause cancer. Also harmful by inhalation
and if swallowed. Also harmful: danger of serious damage to
health by prolonged exposure if swallowed. Also possible risks
of irreversible effects. Very toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
S: 53-45-60-61
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
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Indication of Danger: Toxic.
Risk Statements: May cause cancer. Harmful by inhalation and if
swallowed. Harmful: danger of serious damage to health by
prolonged exposure if swallowed. Possible risk of irreversible
effects. Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
Safety Statements: Restricted to professional users. Attention -
Avoid exposure - obtain special instructions before use. In case
of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). This material and
its container must be disposed of as hazardous waste. Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Liver. Calif. Prop. 65
carcinogen. Probable Carcinogen (US).
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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