SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/31/2008
Date Updated: 02/01/2006
Version 1.3
Section 1 - Product and Company Information
Product Name EUGENOL, 99%
Product Number E51791
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
EUGENOL 97-53-0 No
Formula C10H12O2
Synonyms 4-Allylcatechol-2-methyl ether * p-Allylguaiacol
* 4-Allylguaiacol *
4-Allyl-1-hydroxy-2-methoxybenzene *
4-Allyl-2-methoxyphenol * Caryophyllic acid *
Eugenic acid * Eugenol * p-Eugenol *
1,3,4-Eugenol * FA 100 * FEMA No. 2467 *
1-Hydroxy-2-methoxy-4-allylbenzene *
4-Hydroxy-3-methoxyallylbenzene *
1-Hydroxy-2-methoxy-4-prop-2-enylbenzene *
2-Methoxy-4-allylphenol *
2-Methoxy-1-hydroxy-4-allylbenzene *
2-Methoxy-4-prop-2-enylphenol *
2-Methoxy-4-(2-propenyl)phenol *
2-Metoksy-4-allilofenol (Polish) * NCI-C50453 *
Phenol, 2-methoxy-4-(2-propenyl)- * Synthetic
eugenol
RTECS Number: SJ4375000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed. Irritating to eyes, respiratory system and
skin. May cause sensitization by inhalation and skin contact.
Target organ(s): Kidneys. Central nervous system.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 1
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 1
REACTIVITY: 1
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
233.6 癋 112 癈 Method: closed cup
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
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STORAGE
Suitable: Keep tightly closed. Store in a cool dry place. Store
under nitrogen.
SPECIAL REQUIREMENTS
Store under inert gas. Air sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type AXBEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Clear liquid
Color: Very faintly yellow
Property Value At Temperature or Pressure
Molecular Weight 164.2 AMU
pH N/A
BP/BP Range 253 癈
MP/MP Range - 12.0 - -10. 癈
Freezing Point N/A
Vapor Pressure < 0.1 mmHg 25 癈
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 1.066 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 2.7
Decomposition Temp. N/A
Flash Point 233.6 癋 112 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index 1.541
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
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N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions to Avoid: Air.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
TARGET ORGAN(S) OR SYSTEM(S)
Lungs. G.I. System. Central nervous system. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
1930 mg/kg
LD50
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Coma. Lungs, Thorax, or
Respiration:Dyspnea.
Intratracheal
Rat
11 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Structural or functional
change in trachea or bronchi. Lungs, Thorax, or
Respiration:Acute pulmonary edema. Lungs, Thorax, or
Respiration:Chronic pulmonary edema.
Oral
Mouse
3000 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Intraperitoneal
Mouse
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500 MG/KG
LD50
Intravenous
Mouse
72 MG/KG
LD50
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax, or
Respiration:Respiratory stimulation.
Oral
Guinea pig
2130 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Intratracheal
Hamster
17 MG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Structural or functional
change in trachea or bronchi. Lungs, Thorax, or
Respiration:Acute pulmonary edema. Lungs, Thorax, or
Respiration:Chronic pulmonary edema.
IRRITATION DATA
Skin
Human
40 mg
48H
Remarks: Mild irritation effect
Skin
Man
16 mg
48H
Remarks: Moderate irritation effect
Skin
Rabbit
100 mg
24H
Remarks: Severe irritation effect
Skin
Pig
50 mg
48H
Remarks: Mild irritation effect
Skin
Guinea pig
100 mg
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
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Species: Mouse
Route of Application: Oral
Dose: 37080 MG/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
NTP CARCINOGEN LIST
Rating: Equivocal evidence.
Species: Mouse
Route: Feed
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Dose: 50 UMOL/L
Cell Type: liver
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 296 MG/KG
Exposure Time: 24H
Mutation test: Micronucleus test
Species: Mouse
Route: Oral
Dose: 29589 MG/KG
Exposure Time: 24H
Mutation test: Micronucleus test
Species: Mouse
Dose: 21300 UG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 3 PPM
Cell Type: Embryo
Mutation test: Morphological transformation.
Species: Hamster
Dose: 1 PPM
Cell Type: Embryo
Mutation test: Unscheduled DNA synthesis
Species: Hamster
Dose: 400 MG/L
Cell Type: ovary
Mutation test: Other mutation test systems
Species: Hamster
Dose: 125 MG/L
Cell Type: fibroblast
Mutation test: Cytogenetic analysis
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Species: Hamster
Dose: 300 MG/L
Cell Type: ovary
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 75 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 300 PPB
Cell Type: Embryo
Mutation test: Sister chromatid exchange
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 22-36/37/38-42/43
Risk Statements: Harmful if swallowed. Irritating to eyes,
respiratory system and skin. May cause sensitization by
inhalation and skin contact.
S: 26-36
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed. Irritating to eyes,
respiratory system and skin. May cause sensitization by
inhalation and skin contact.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing.
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US Statements: Target organ(s): Kidneys. Central nervous system.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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