SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 03/18/2008
Date Updated: 02/02/2006
Version 1.4
Section 1 - Product and Company Information
Product Name 2,4-DINITROANILINE, 98%
Product Number D193011
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
2,4-DINITROANILINE 97-02-9 No
Formula C6H5N3O4
Synonyms Benzenamine, 2,4-dinitro- (9CI) *
2,4-Dinitraniline * 2,4-Dinitroanilin (German) *
2,4-Dinitroanilina (Italian) * 2,4-Dinitroaniline
* 2,4-Dinitrobenzenamine * NCI-C60753
RTECS Number: BX9100000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU). Dangerous for the environment.
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Toxic to aquatic organisms, may
cause long-term adverse effects in the aquatic environment.
Irritating to eyes, respiratory system and skin.
Target organ(s): Blood.
HMIS RATING
HEALTH: 3*
FLAMMABILITY: 1
REACTIVITY: 1
NFPA RATING
HEALTH: 3
FLAMMABILITY: 1
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
EXPLOSION HAZARDS
May be heat and shock sensitive.
FLASH POINT
435.2 癋 224 癈 Method: closed cup
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
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Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face particle respirator type N100 (US) or
type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a
full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: Deep yellow
Property Value At Temperature or Pressure
Molecular Weight 183.12 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 176 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content 10 %
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 435.2 癋 224 癈 Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
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Materials to Avoid: Strong acids, Acid chlorides, Acid anhydrides,
Reacts violently with:, Chlorine, Strong oxidizing agents,
Hydrochloric acid.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be fatal if absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be fatal if inhaled.
Ingestion: May be fatal if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Blood.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer. Exposure can cause: Nausea,
dizziness, and headache.
TOXICITY DATA
Oral
Rat
285 mg/kg
LD50
Oral
Mouse
370 mg/kg
LD50
Oral
Guinea pig
1050 mg/kg
LD50
IRRITATION DATA
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1100 UG/M3/4H
Route of Application: Inhalation
Exposure Time: (1-7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
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e.g., stunted fetus).
Species: Rat
Dose: 17 MG/M3/4H
Route of Application: Inhalation
Exposure Time: (1-7D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - MUTAGEN
Species: Rat
Dose: 50 UMOL/L
Cell Type: liver
Mutation test: Unscheduled DNA synthesis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 17 MG/M3/4H
Route of Application: Inhalation
Exposure Time: (1-7D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Dinitroanilines
UN#: 1596
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Dinitroanilines
IATA UN Number: 1596
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: T+-N
Indication of Danger: Very toxic. Dangerous for the environment.
R: 26/27/28-33-51/53
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed. Danger of cumulative effects. Toxic to aquatic
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organisms, may cause long-term adverse effects in the aquatic
environment.
S: 28-36/37-45-61
Safety Statements: After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible). Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Dangerous for the environment.
Risk Statements: Very toxic by inhalation, in contact with skin
and if swallowed. Danger of cumulative effects. Toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment. Irritating to eyes, respiratory system and skin.
Safety Statements: After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible). Avoid
release to the environment. Refer to special instructions/safety
data sheets.
US Statements: Target organ(s): Blood.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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