MATERIAL SAFETY DATA SHEET CACODYLIC ACID
PRODUCT CODE NUMBER(S): 2690-5
PRODUCT IDENTIFICATION FIRE AND EXPLOSION DATA
Chemical Name and Synonyms: Cacodylic acid; Flammability: Not combustible. Not expected to be an ex-
Dimethylarsinic acid; Hydroxydimethylarsine oxide plosion hazard.
Chemical Family: Organo-arsenic compound Extinguishing Media: Use an extinguisher appropriate to
the surrounding material that is burning. Use water as spray
Chemical Formula: C2H7AsO2
or fog to cool containers, prevent dust formation, flush
Product Use: Laboratory reagent chemcial away from fire. Fight fire from upwind, from a safe
Manufacturer's Name and Address: distance. Firefighters must wear protective equipment (posi-
Caledon Laboratories Ltd. tive-pressure, full face-piece self-contained breathing
apparatus) and clothing (chemical splash suit) sufficient to
40 Armstrong Avenue
prevent inhalation of dust or fumes, and contact with skin,
Georgetown, Ontario L7G 4R9
eyes, and clothing.
Telephone No: (905) 877-0101
Flash Point (Method Used): None
Fax No: (905) 877-6666
Autoignition Temperature: Not applicable
Emergency Telephone No: CANUTEC (613) 996-6666
Upper Flammable Limit (% by volume): Not applicable
HAZARDOUS INGREDIENTS OF MATERIALS Lower Flammable Limit (% by volume): Not applicable
Hazardous Combustion Products: COx, arsenic oxides,
Ingredients % TLV Units CAS No. toxic gases.
Sensitivity to Impact: None identified
3
Cacodylic acid >98 0.01 mg/m 75-60-5
Sensitivity to Static discharge: None identified
(as As)
TOXICOLOGICAL PROPERTIES AND HEALTH DATA
PHYSICAL DATA
Physical State: Solid Toxicological Data:
Odour and Appearance: White crystals, odourless LD50: (oral, rat) 644 mg/kg
Odour Threshold (ppm): Not applicable LCLO: Not available
Vapour Pressure (mm Hg): Not available
Vapour Density (Air = 1): Not available Effects of Acute Exposure to Product:
Evaporation Rate: Not available Toxic by all routes of exposure.
Boiling Point (degrees C): >200癈 Inhaled: Highly toxic. Readily absorbed through respiratory
Melting Point (degrees C): 195 to 196癈 tract. Inhalation of dust, mist or vapour may cause short-
ness of breath, rapid heart beat, headache, restlessness,
pH: 1 (0.1M, calc.)
low blood pressure, convulsions, collapse and death from
Specific Gravity: >1.1 @ 20癈
circulatory failutre. May cause severe irritation of mucous
Coefficient of Water/Oil distribution: Not available membranes and pulmonary edema, with cough, frothy spu-
tum, noisy breathing, shortness of breath, cyanosis, and
SHIPPING DESCRIPTION death.
In contact with skin: Highly toxic. May cause irritation,
UN: 1572
with redness and pain. Exposure to arsenic compounds
T.D.G. Class: 6.1 may produce hyperpigmentation of the skin and
Pkg. Group: II hyperkeratoses of plantar and palmar surfaces. May be ab-
sorbed through skin, with symptoms as in "Ingested".
REACTIVITY DATA In contact with eyes: May cause moderate to severe irrita-
tion, with redness, tearing, pain, possible damage to
Chemical Stability: Stable, deliquescent
conjunctiva.
Incompatibility with other substances: May react vio- Ingested: Highly toxic. Causes burning in throat and
lently or explosively with strong oxidizng agents, strong esophagus, severe abdominal pain, nausea, projectile vom-
acids, strong bases. Reacts with acid to form highly toxic iting, vomiting of blood, bloody diarrhea and shock with
gas, dimethylarsine. Aqueous solutions react violently with weak, rapid pulse, shallow breathing, strong odour of garlic
active metals. on breath, in urine and sweat. May cause severe damage to
Reactivity: Avoid excessive heat, ignition sources, incom- liver and kidneys. Ingestion of arsenic compounds can
patible materials, generation of dust. cause convulsions, coma, and possibly death within 24
Hazardous Decomposition Products: COx, arsenic ox- hours. Estimated lethal dose for humans, 120 mg.
ides, toxic gases.
MSDS CACODYLIC ACID
CODE: 2690-5
Effects of Chronic Exposure to Product: from damage, and inspect frequently for signs of damage or
leaking.
Prolonged or repeated skin exposure to arsenic can cause
bronzing of the skin, edema, dermatits, lesions. Prolonged FIRST AID MEASURES
or repeated inhalation can cause damage to nasal septum.
Chronic exposure may cause hair and weight loss, garlic Specific Measures:
odour on the breath and in perspiration, excessive salivation
Eyes: Flush thoroughly with running water for at least fif-
and perspiration, damage to liver, kidneys, gastrointestinal
teen (15) minutes, holding eyelids open while flushing.
cardiovascular, and central nervous systems, bone marrow,
Take care not to flush contaminated water into unaffected
cellular composition of the blood. eye. Wear protective gloves to avoid contact during first aid
Carcinogenicity: Possible carcinogen. IARC group 1, car- procedures. Get medical advice immediately.
cinogenic to humans. ACGIH, NTP have no listing for this Skin: Remove contaminated clothing (including shoes,
chemical watches, belts, rings). Drench skin with plenty of running
Teratogenicity: Possible teratogen. Evidence inconclusive water for at least fifteen (15) minutes. Get medical attention
at present; has caused effects in animal testing. immediately. Decontaminate clothing completely before re-
Reproductive Effects: Has caused effects in testing with use, or discard; inform laundry of hazards of contaminated
laboratory animals clothing.
Mutagenicity: Has caused mutagenic effects in humans Inhalation: Immediately remove to fresh air (caution must
be used by rescuers to avoid exposure to contaminating
Synergistic Products: None known
dust or fumes). Give oxygen or get medical attention for
any breathing difficulty. If breathing has stopped begin artifi-
PREVENTIVE MEASURES
cial respiration immediately. Use mouth guard to avoid
Engineering Controls: Local exhaust ventilation required. contact. GET MEDICAL ATTENTION. Onset of symptoms
may be delayed; if victim feels unwell during the next 24
Respiratory Protection: Dust/mist mask. Use in a
hours, get medical attention immediately.
fumehood. Up to 10x TLV, or the maximum use specified by
Ingestion: If victim is alert and not convulsing, rinse mouth
the respirator supplier, whichever is lowest, NIOSH/OSHA
thoroughly with water, give 2 to 4 glasses of water to drink
approved half- face dust/mist filter respirator. Up to 50x TLV,
to dilute, and induce vomiting by sticking a finger down the
or the maximum use specified by the respirator supplier,
throat, or by giving syrup of ipecac. GET MEDICAL ATTEN-
whichever is lowest, NIOSH/OSHA approved full face-piece
TION. If spontaneous vomiting occurs, rinse mouth
dust/mist filter respirator. Higher or unknown concentra-
thoroughly with water, and give 2 to 4 more glasses of water
tions, or for fire or spill conditions, self-contained breathing
to drink. Onset of symptoms may be delayed; if victim feels
apparatus, or full face-piece, positive-pressure supplied-air
unwell during the next 24 hours, get medical attention im-
respirator.
mediately.
Eye Protection: Chemical safety goggles or face shield.
Note to physician: If emesis is unsuccessful after two
Do not wear contact lenses when working with chemicals.
doses of ipecac, consider gastric lavage. Monitor urine ar-
Skin Protection: Impervious rubber or plastic gloves. Im-
senic level. Alkalization of urine may help prevent
pervious apron, sleeve and boots sufficient to prevent
disposition of red cell breakdown products in renal cell tubu-
contact.
lar cells. Abdominal x-rays should be done for all
Other Personal Protective Equipment: Safety shower
ingestions. Chelation therapy with BAL, followed by
and eye-wash fountain in work area.
n-penicillamine may be useful, but dosing guidelines are not
Leak and Spill Procedure: Evacuate area of spill. clearly established.
Cleanup personnel must be thoroughly trained in the han-
dling of hazardous materials, and must wear protective
REFERENCES USED
equipment and clothing sufficient to prevent inhalation of
dusts or fumes and contact with skin and eyes. Do not CCINFO disc: Cheminfo, MSDS's
touch spilled material. Avoid raising dust. Mix with wet Budavari: The Merck Index, 12th ed., 1997
sand, 10 to 20 times by weight, transfer carefully into con-
Sax, Lewis: Hawley's Condensed Chemical Dictionary, 11th
tainer and arrange removal by disposal company. Wash site
ed., 1987
of spillage thoroughly with water and detergent.
Suppliers' Material Safety Data Sheets
Waste Disposal: Follow all federal, provincial and local
regulations for disposal.
ADDITIONAL INFORMATION
Handling Procedures and Equipment: HIGHLY TOXIC.
Workers must be thoroughly trained in the hazards of this
Date Issued: May 20, 1999
substance and its safe use, and must wear appropriate pro-
Revision: May 2008
tective equipment and clothing. Avoid all contact and
inhalation. Avoid generating dust. Use the smallest amount MSDS: 2690-5
possible for the purpose, in a a designated area with ade- Proposed WHMIS Designation: D1A; D2A; D2B
quate ventilation. Use good housekeeping procedures to
minimize production of dust. Keep work area free of extra-
Prepared by: Caledon Laboratories Ltd. (905) 877-0101
neous materials. Wear appropriate protective clothing, and
Caledon Laboratories Ltd. believes the information contained
wash thoroughly after working with this chemical. Empty
herein is reliable and accurate. Caledon makes no warranty
containers may contain hazardous residues; treat with ex-
with respect thereto and expressly disclaims all liability for reli-
treme caution.
ance thereon. Such information is solely for your consider-
Storage Requirements: Store in suitable, labelled contain-
ers, in a cool, dry, well-ventilated area, out of direct sunlight ation, investigation, and verification.
and away from all incompatible materials. Keep containers
tightly closed when not in use and when empty. Protect
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