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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
* 1 Identification of substance:
?Product details:
?Trade name: Propylene oxide
?Synonyma
Methyloxirane
1,2-Epoxypropane
?Article number: 33715
?Application of the substance / the preparation Laboratory chemicals
?Manufacturer/Supplier:
SERVA Electrophoresis GmbH
Carl-Benz-Str. 7
D-69115 Heidelberg
Tel.: +49 6221 13840-0
FAX: +49 6221 13840-10
msds.info@serva.de
?Information department: Product Safety department Tel.: +49 6221 13840-35
?Emergency information: +49 6131 19240 (university hospital Mainz)
* 2 Hazards identification
?Hazard description:
T Toxic
F+ Extremely flammable
?Information pertaining to particular dangers for man and environment
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 12 Extremely flammable.
R 20/21/22 Also harmful by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Only for trade users / technical specialists
?Classification system
The classification was made according to the latest editions of the EU-lists, and expanded upon fom company
and literature data.
?GHS label elements
Danger
2.6/1 - Extremely flammable liquid and vapour.
Danger
3.1/3 - Toxic if swallowed.
3.1/3 - Toxic in contact with skin.
3.1/4 - Harmful if inhaled.
3.2/2 - Causes skin irritation.
3.3/2A - Causes serious eye irritation.
3.8/3 - May cause respiratory irritation.
(Contd. on page 2)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 1)
Danger
3.5/1B - May cause genetic defects.
3.6/1B - May cause cancer.
?Prevention:
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Ground/bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting/ equipment.
Use only non-sparking tools.
Take precautionary measures against static discharge.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective gloves/protective clothing/eye protection/face protection.
Use personal protective equipment as required.
?Response:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF ON SKIN: Wash with plenty of soap and water.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/
shower.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing.
IF exposed or concerned: Get medical advice/attention.
Call a POISON CENTER or doctor/physician if you feel unwell.
Specific treatment (see label).
Specific measures (see label).
Rinse mouth.
If skin irritation occurs: Get medical advice/attention.
If eye irritation persists: Get medical advice/attention.
Remove/Take off immediately all contaminated clothing.
Take off contaminated clothing and wash before reuse.
Wash contaminated clothing before reuse.
In case of fire: Use for extinction: CO2, powder or water spray.
?Storage:
Store in a well-ventilated place. Keep container tightly closed.
Store in a well-ventilated place. Keep cool.
Store locked up.
?Disposal:
Dispose of contents/container in accordance with local/regional/national/international regulations.
* 3 Composition/information on ingredients
?Chemical characterization:
?CAS No. Description:
75-56-9 Methyloxirane
?Identification number(s):
?EINECS Number: 200-879-2
?Index number: 603-055-00-4
?Chemical characterization
?Description:
?Empirical formula: C H O
(Contd. on page 3)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 2)
?MW: 58,1
* 4 First aid measures
?General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48
hours after the accident.
Remove contaminated clothing.
?After inhalation Supply fresh air or oxygen; call for doctor.
?After skin contact Immediately wash with water and soap and rinse thoroughly.
?After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult doctor.
?After swallowing
Rinse out mouth and then drink plenty of water.
Call a doctor immediately.
* 5 Fire fighting measures
?Suitable extinguishing agents
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
?Protective equipment: Wear self-contained respiatory protective device.
* 6 Accidental release measures
?Person-related safety precautions: Wear protective equipment. Keep unprotected persons away.
?Measures for environmental protection:
Do not allow to penetrate the ground/soil.
Do not allow to enter sewers/ surface or ground water.
?Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
* 7 Handling and storage
?Handling
?Information for safe handling:
Ensure good ventilation/exhaustion at the workplace.
Open and handle receptacle with care.
?Information about protection against explosions and fires:
Fumes can combine with air to form an explosive mixture.
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Keep respiratory protective device available.
?Storage
?Requirements to be met by storerooms and receptacles:
Store in a cool location.
Store only in the original receptacle.
?Information about storage in one common storage facility: Not required.
?Further information about storage conditions:
Store receptacle in a well ventilated area.
Store in cool, dry conditions in well sealed receptacles.
Protect from heat and direct sunlight.
(Contd. on page 4)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 3)
Store under lock and key and with access restricted to technical experts or their assistants only.
* 8 Exposure controls and personal protection
?Additional information about design of technical systems: No further data; see item 7.
?Components with limit values that require monitoring at the workplace:
75-56-9 Methyloxirane (80-100%)
WEL Long-term value: 12 mg/m? 5 ppm
Carc
?Additional information: The lists that were valid during the creation were used as basis.
?Personal protective equipment
?General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
?Breathing equipment:
Short term filter device:
Filter AX.
?Protection of hands:
Protective gloves.
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/
the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradation
?Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality
and varies from manufacturer to manufacturer.
?Penetration time of glove material
The exact break trough time has to be found out by the manufacturer of the protective gloves and has to be
observed.
?For the permanent contact of a maximum of 15 minutes gloves made of the following materials are
suitable:
Neoprene gloves
?Not suitable are gloves made of the following materials:
Natural rubber, NR
Butyl rubber, BR
?Eye protection: Tightly sealed goggles.
?Body protection: Protective work clothing.
* 9 Physical and chemical properties:
?General Information
Liquid
Form:
Colourless
Colour:
Ether-like
Odour:
?Change in condition
Melting point/Melting range: - 112癈
Boiling point/Boiling range: 34癈
-37癈
?Flash point:
(Contd. on page 5)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 4)
430癈
?Ignition temperature:
Product is not explosive. However, formation of explosive air/vapour
?Danger of explosion:
mixtures are possible.
?Explosion limits:
1.9 Vol %
Lower:
38.8 Vol %
Upper:
590 hPa
?Vapour pressure at 20癈:
0.83 g/cm?br>
?Density at 20癈:
?Solubility in / Miscibility with
405 g/l
Water at 20癈:
~7
?pH-value (400 g/l) at 20癈:
?Viscosity:
0.38 mPas
dynamic at 10癈:
There are no more data available.
?Additional information
* 10 Stability and reactivity
?Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
?Dangerous reactions Danger of polymerisation
?Dangerous products of decomposition:
Carbon monoxide and carbon dioxide
Irritant gases/vapours
* 11 Toxicological information
?Acute toxicity:
?LD/LC50 values that are relevant for classification:
Oral LD50 380 mg/kg (rat)
Dermal LD50 1245 mg/kg (rbt)
LC50/96h 215 mg/l (Fish)
?Primary irritant effect:
?on the skin: Irritant to skin and mucous membranes.
?on the eye: Irritating effect.
?Sensitization: No sensitizing effects known.
?Additional toxicological information:
After inhalation: mucous membran irritation, cough, dispnoea, sickness, dysentery, amentia
?CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)
Carc. Cat. 2, Muta. Cat. 2
* 12 Ecological information:
?Information about elimination (persistence and degradability):
?Other information:
The product is difficultly biodegradable.
12 - 14 % in 28 d
?Behaviour in environmental systems:
?Mobility and bioaccumulation potential:
Due to the distribution coefficient n-octanol/water an accumulation in organisms is not expected.
(Contd. on page 6)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 5)
?Ecotoxical effects:
?Acquatic toxicity:
EC50/48h 350 mg/l (Daphnia magna)
?Remark:
EC50 / 96 h (Algae): 240 mg/l
EC10 / 17h (Bacteria): 10mg/l (DIN 38412 part 8)
?General notes:
Water danger class 3 (German Regulation) (Assessment by list): extremely hazardous for water.
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
* 13 Disposal considerations
?Product:
?Recommendation Must be specially treated adhering to official regulations.
?Uncleaned packagings:
?Recommendation:
Empty contaminated packagings thoroughly. They can be recycled after thorough and proper cleaning.
Packagings that cannot be cleansed are to be disposed of in the same manner as the product.
?Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
?Land transport ADR/RID (cross-border)
3 Flammable liquids.
?ADR/RID class:
33
?Danger code (Kemler):
1280
?UN-Number:
I
?Packaging group:
3
?Label
1280 PROPYLENE OXIDE
?Description of goods:
?Maritime transport IMDG:
3
?IMDG Class:
1280
?UN Number:
3
?Label
I
?Packaging group:
F-E,S-D
?EMS Number:
No
?Marine pollutant:
?Propper shipping name: PROPYLENE OXIDE
?Air transport ICAO-TI and IATA-DGR:
3
?ICAO/IATA Class:
(Contd. on page 7)
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Safety Data Sheet
according to 1907/2006/EC, Article 31
Printing date 16.10.2008 Revision: 16.10.2008
Trade name: Propylene oxide
(Contd. of page 6)
1280
?UN/ID Number:
3
?Label
I
?Packaging group:
?Propper shipping name: PROPYLENE OXIDE
?UN "Model Regulation": UN1280, PROPYLENE OXIDE, 3, I
* 15 Regulations
?Markings according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on Hazardous
Materials
?Code letter and hazard designation of product:
T Toxic
F+ Extremely flammable
?Risk phrases:
45 May cause cancer.
46 May cause heritable genetic damage.
12 Extremely flammable.
20/21/22 Also harmful by inhalation, in contact with skin and if swallowed.
36/37/38 Irritating to eyes, respiratory system and skin.
?Safety phrases:
53 Avoid exposure - obtain special instructions before use.
45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
?Special labeling of certain preparations:
Only for trade users / technical specialists
?National regulations
?Technical instructions (air):
Class Share in %
III 80-100
?Water hazard class: Water danger class 3 (Assessment by list): extremely hazardous for water.
16 Other information:
This information is based on our present knowledge. However, this shall not constitute a guarantee for any
specific product features and shall not establish a legally valid contractual relationship.
?Department issuing MSDS: Product safety department
?Contact: +49 6221 13840-35
?Abbreviations and acronyms:
ADR: Accord europ閑n sur le transport des marchandises Dangereuses par Route (European Agreement concerning the International
Carriage of Dangerous Goods by Road)
RID: Reglement internationale concernent le transport des merchandises dangereuses par chemin de fer (Regulations Concerning the
International Transport of Dangerous Goods by Rail)
IMDG: International Maritime Code for Dangerous Goods
IATA: International Air Transport Association
IATA-DGR: Dangerous Goods Regulations by the "International Air Transport Association" (IATA)
ICAO: International Civil Aviation Organization
ICAO-TI: Technical Instructions by the "International Civil Aviation Organization" (ICAO)
GHS: Globally Harmonized System of Classification and Labelling of Chemicals
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
?* Data compared to the previous version altered.
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