|
Section 1 - Chemical Product and Company Identification |
MSDS Name: p-Nitrophenol
Catalog Numbers:
BP612 1, BP612-1, BP6121, BP6121000
Synonyms:
4-Hydroxynitrobenzene; 4-Nitrophenol.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
|
Section 2 - Composition, Information on Ingredients
|
| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 100-02-7 | p-Nitrophenol |
98 | 202-811-7 |
Hazard Symbols: XN
Risk Phrases: 20/21/22 33
|
Section 3 - Hazards Identification
|
EMERGENCY OVERVIEW
Appearance: yellow solid.
May cause methemoglobinemia. May cause central nervous system
effects. May cause cyanosis (bluish discoloration of skin due to
deficient oxygenation of the blood). Warning!
Causes eye irritation. Causes severe skin irritation. May cause
respiratory and digestive tract irritation. Harmful if swallowed. May
cause kidney damage.
Target Organs: Blood, central nervous system.
Potential Health Effects
Eye:
Causes severe eye irritation.
Skin:
Causes severe skin irritation. If absorbed, causes symptoms similar
to those of ingestion.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause kidney damage. May cause
central nervous system depression, characterized by excitement,
followed by headache, dizziness, drowsiness, and nausea. Advanced
stages may cause collapse, unconsciousness, coma and possible death
due to respiratory failure. May cause methemoglobinemia, cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood), convulsions, and death. Methemoglobinemia is characterized
by dizziness, drowsiness, headache, shortness of breath, cyanosis
(bluish discoloration of skin due to deficient oxygenation of the
blood), rapid heart rate and chocolate-brown colored blood. May cause
cyanosis (bluish discoloration of skin due to deficient oxygenation
of the blood). Ingestion may produce shock, collapse, and
convulsions.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to
those described for ingestion.
Chronic:
Chronic inhalation and ingestion may cause effects similar to those
of acute inhalation and ingestion.
|
Section 4 - First Aid Measures
|
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse. Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish
discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive
measures: bed rest and oxygen inhalation. For methemoglobinemia,
administer oxygen alone or with Methylene Blue depending on the
methemoglobin concentration in the blood. Cleansing of the entire
contaminated area of the body is of utmost importance.
|
Section 5 - Fire Fighting Measures
|
General Information:
Evacuate area and fight fire from a safe distance. As in any fire,
wear a self-contained breathing apparatus in pressure-demand,
MSHA/NIOSH (approved or equivalent), and full protective gear.
Combustion generates toxic fumes. Containers may explode in the heat
of a fire. Combustible material; even though it may take some effort
to ignite.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: Not available.
Autoignition Temperature: 541 deg F ( 282.78 deg C)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 2
|
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Remove all sources of
ignition. Provide ventilation.
|
Section 7 - Handling and Storage
|
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes,
skin, and clothing. Keep container tightly closed. Keep away from
heat, sparks and flame. Do not ingest or inhale. Wash clothing before
reuse.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Keep away from food
and drinking water. Keep from contact with oxidizing materials. Store
in a cool, dry, well-ventilated area away from incompatible
substances.
|
Section 8 - Exposure Controls, Personal Protection
|
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| p-Nitrophenol | none listed |
none listed | none listed |
OSHA Vacated PELs:
p-Nitrophenol:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Always use
a NIOSH or European Standard EN 149 approved
respirator when necessary.
|
Section 9 - Physical and Chemical Properties
|
Physical State: Solid
Appearance: yellow
Odor: odorless
pH: Not available.
Vapor Pressure: .6 mm Hg @ 120 deg
Vapor Density: 4.8
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 534 deg F
Freezing/Melting Point:113.4 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble.
Specific Gravity/Density: 1.479 - 1.495
Molecular Formula:C6H5NO3
Molecular Weight:139.0399
|
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, temperatures above 125癈.
Incompatibilities with Other Materials:
Strong oxidizing agents; Strong bases; Diethyl phosphite
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
|
Section 11 - Toxicological Information
|
RTECS#:
CAS# 100-02-7: SM2275000
LD50/LC50:
CAS# 100-02-7:
Dermal, guinea pig: LD50 = >1 gm/kg;
Oral,
mouse: LD50 = 282 mg/kg;
Oral, rat: LD50 = 202 mg/kg;
Skin,
rat: LD50 = 1024 mg/kg;
Carcinogenicity:
CAS# 100-02-7:
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
Human mutation data has been reported.
Teratogenicity:
No information available.
Reproductive Effects:
No information available.
Neurotoxicity:
No information available.
Mutagenicity:
Mutagenic effects have occurred in experimental animals. Mutagenic
effects have occurred in humans.
Other Studies:
See actual entry in RTECS for complete information.
|
Section 12 - Ecological Information
|
No information available.
|
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 100-02-7: waste number
U170.
|
Section 14 - Transport Information
|
| |
US DOT |
IATA |
RID/ADR |
IMO |
Canada TDG |
| Shipping Name: |
NITROPHENOLS |
|
|
|
NITROPHENOLS |
| Hazard Class: |
6.1 |
|
|
|
6.1 |
| UN Number: |
UN1663 |
|
|
|
UN1663 |
| Packing Group: |
III |
|
|
|
III |
|
Section 15 - Regulatory Information
|
US FEDERAL
TSCA
CAS# 100-02-7 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 100-02-7: Effective 4/13/89; Sunset 6/30/98
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 100-02-7: 100 lb final RQ (Listed under Nitrophenol, mixed); 45.4 kg final RQ (Listed
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 100-02-7: acute, chronic, reactive.
Section 313
This material contains p-Nitrophenol (CAS# 100-02-7, 98%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 373.
Clean Air Act:
CAS# 100-02-7 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 100-02-7 is listed as a Hazardous Substance under the CWA.
CAS# 100-02-7 is listed as a Priority Pollutant under the Clean Water
Act.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
CAS# 100-02-7 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Massachusetts.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
WGK (Water Danger/Protection)
CAS# 100-02-7: 2
Canada - DSL/NDSL
CAS# 100-02-7 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B, D2B.
Canadian Ingredient Disclosure List
CAS# 100-02-7 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
|
Section 16 - Additional Information
|
MSDS Creation Date: 5/14/1998
Revision #4 Date: 3/18/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
|
|