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Section 1 - Chemical Product and Company Identification |
MSDS Name: Rhodamine B
Catalog Numbers:
AC132310000, AC132310250, AC132311000, AC132315000, AC296570000,
AC296570100, AC296570250, AC419000000, AC419000010, R21-100
Synonyms:
9-(2-Carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride;
(9-Carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-y
lidene)diethylammonium chloride; C.I. Basic Violet 10; C.I. 45170;
Tetraethylrhodamine; Basic Violet 10.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 81-88-9 |
Rhodamine B |
>97 | 201-383-9 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: dark green crystals.
Warning! Eye contact may result in permanent eye
damage. Harmful if swallowed. Possible risks of irreversible effects.
Target Organs: Kidneys, liver, respiratory
system, eyes.
Potential Health Effects
Eye:
Risk of serious damage to eyes.
Skin:
May cause skin irritation. May be harmful if absorbed through the
skin.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with
nausea, vomiting and diarrhea.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
May cause cancer according to animal studies. Possible risk of
irreversible effects.
Rhodamine B has caused tumors or has been a questionable tumorigenic
agent in studies of subcutaneous injection in rats (RTECS , 2001).
It increased thyroid and liver tumors in mice (Opresko, 1982) and
produced lymphomas and intestinal tumors when given to mice in the
drinking water (HSDB , 1997). However, Rhodamine B was not
carcinogenic when given at up to 4% in the diet to rats for two years
(Opresko, 1982). IARC has determined that rhodamine B has limited
evidence of being an experimental animal carcinogen (Group 3) (RTECS
,
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Immediately flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Get medical aid immediately. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing
is difficult, give oxygen. Get medical aid if cough or other symptoms
appear. Do not use mouth-to-mouth resuscitation if victim ingested or
inhaled the substance; induce artificial respiration with the aid of
a pocket mask equipped with a one-way valve or other proper
respiratory medical device.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid generating dusty conditions. Provide ventilation. Do
not let this chemical enter the environment.
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Section 7 - Handling and Storage
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Handling:
Minimize dust generation and accumulation. Do not get in eyes, on
skin, or on clothing. Do not ingest or inhale. Use with adequate
ventilation.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Rhodamine B
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Rhodamine B:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
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Section 9 - Physical and Chemical Properties
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Physical State: Crystals
Appearance: dark green
Odor: strong odor
pH: Not available.
Vapor Pressure: Negligible.
Vapor Density: Not available.
Evaporation Rate:Negligible.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:210 - 211 deg C(decom)
Decomposition Temperature:> 255 deg C
Solubility: Soluble.
Specific Gravity/Density:>1.0
Molecular Formula:C28H31ClN2O3
Molecular Weight:479.01
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 81-88-9:
BP3675000
LD50/LC50:
CAS# 81-88-9:
Oral, mouse: LD50 =
887 mg/kg;
.
Oral LD50 rat: 400-800 mg/kg. Dermal LD50 gpg: > 1.0 g/kg. Skin
irritation study in gpg: Slight irritant. Chronic feeding studies in
lab animals have indicated overexposure to Rhodamine B may cause
liver and thryroid cancer. (Eastman Kodak)
Carcinogenicity:
CAS# 81-88-9:
- ACGIH:
Not listed.
- California:
carcinogen, initial date 7/1/90
- NTP:
Not listed.
- IARC:
Not listed.
Epidemiology:
Tumorigenic effects have been reported in experimental
animals.
Teratogenicity:
Teratogenic effects have occurred in experimental animals.
Reproductive Effects:
Mice dosed with 60 mg/kg Rhodamine B intraperitoneally on
days 7 through 10 of their pregnancies experienced
significant fetotoxicity.
Mutagenicity:
Mutagenic effects have occurred in experimental animals.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information available.
Physical:
No information available.
Other:
Do not empty into drains.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not Regulated |
Not Regulated |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 81-88-9 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 81-88-9: immediate, delayed.
Section 313
This material contains Rhodamine B
(CAS# 81-88-9, >97%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 81-88-9 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Rhodamine B, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
R 41 Risk of serious damage to eyes.
R 68 Possible risk of irreversible effects.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
WGK (Water Danger/Protection)
CAS# 81-88-9: 2
Canada - DSL/NDSL
CAS# 81-88-9 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 81-88-9 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 12/12/1997
Revision #9 Date: 7/23/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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