Analysis

Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
75-31-0	Isopropylamine	99	200-860-9

Section 3 - Hazards Identification

Appearance: clear, colorless liquid. Flash Point: -37 deg C.
Danger! Extremely flammable liquid and vapor. Vapor may cause flash fire. Causes eye and skin burns. Causes digestive and respiratory tract burns. Harmful if swallowed, inhaled, or absorbed through the skin.
Target Organs: Eyes, skin, mucous membranes.


Potential Health Effects
Eye: Low vapor concentrations may cause a temporary visual disturbance known as 'blue haze' or 'halo vision'. Causes eye irritation and burns. May cause tearing, conjunctivitis and corneal edema when vapor is absorbed into the tissue of the eye. Direct contact with liquid may cause blindness or permanent eye damage.
Skin: Harmful if absorbed through the skin. Causes severe skin irritation and burns. One review describes isopropylamine as causing skin sensitization in very rare cases. This report cannot be confirmed. Otherwise, there are no human or animal reports of isopropylamine causing skin sensitization.
Ingestion: Harmful if swallowed. Causes gastrointestinal tract burns. May cause central nervous system effects. Central nervous system signs were observed during acute oral toxicity testing in rats.
Inhalation: Can produce delayed pulmonary edema. Causes respiratory tract irritation with possible burns.
Chronic: Prolonged or repeated skin contact may cause dermatitis.

Section 4 - First Aid Measures

Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid immediately.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do NOT induce vomiting. Get medical aid immediately. If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extremely flammable liquid and vapor. Vapor may cause flash fire. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media: Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Water may be ineffective because it will not cool material below its flash point.
Flash Point: -37 deg C ( -34.60 deg F)
Autoignition Temperature: 402 deg C ( 755.60 deg F)
Explosion Limits, Lower:2.0 vol %
Upper: 10.4 vol %
NFPA Rating: (estimated) Health: 3; Flammability: 4; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Storage: Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Isopropylamine	5 ppm TWA; 10 ppm STEL	750 ppm IDLH	5 ppm TWA; 12 mg/m3 TWA

OSHA Vacated PELs: Isopropylamine: 5 ppm TWA; 12 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear chemical splash goggles and face shield.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear, colorless
Odor: ammonia-like
pH: 11.8 (0.1M aq soln)
Vapor Pressure: 580 mm Hg @ 25 deg C
Vapor Density: 2.03 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 33-34 deg C
Freezing/Melting Point:-101 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:0.69
Molecular Formula:C3H9N
Molecular Weight:59.11

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: High temperatures, ignition sources, confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information

RTECS#:      
CAS# 75-31-0: NT8400000
LD50/LC50:
CAS# 75-31-0:
     Draize test, rabbit, eye: 100 uL Severe;
     Inhalation, rat: LC50 = 4000 ppm/4H;
     Oral, mouse: LD50 = 2200 mg/kg;
     Oral, rabbit: LD50 = 3200 mg/kg;
     Oral, rat: LD50 = 111 mg/kg;
     Skin, rabbit: LD50 = 380 mg/kg;
.

Carcinogenicity:
CAS# 75-31-0: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: Nose & throat irritation were reported by volunteer subjects after brief exposures at 10-20 ppm isopropylamine. Workers complained of transient visual problems (halos around lights) after exposure to vapor for 8 hrs which usually cleared in 3-4 hrs.
Teratogenicity: No information available.
Reproductive Effects: No information found
Mutagenicity: No information found
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: Water flea Daphnia: EC50 = 91.5-91.6 mg/L; 48 Hr; Unspecified Based on the vapor pressure, isopropylamine should rapidly evaporate from dry surfaces, especially when present in high concn such as in spill situations. The miscibility of isopropylamine in water suggests that adsorption and bioconcentration, in addition to volatilization, are not important fate processes. This is supported by low estimates for the bioconcentration factor (log BCF = 0.43) and soil adsorption coefficient (Koc = 33).
Environmental: Isopropylamine has the potential to bind to soil and partition from the water column to sediments and suspended solids. Limited data suggests isopropylamine should biodegrade rapidly in soil and water; however, it may be toxic to micro-organisms at high concn. Isopropylamine is expected to exist almost entirely in the vapor phase in ambient air, where vapor phase reactions with photochemically produced hydroxyl radicals may be important (estimated half-life of 10 hrs).
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	ISOPROPYLAMINE	ISOPROPYLAMINE
Hazard Class:	3	3(8)
UN Number:	UN1221	UN1221
Packing Group:	I	I
Additional Info:		FLASHPOINT -37 C

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 75-31-0 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 75-31-0: immediate, fire.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     CAS# 75-31-0 is considered highly hazardous by OSHA.
STATE
     CAS# 75-31-0 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XI F+
Risk Phrases:
     R 12 Extremely flammable.
     R 36/37/38 Irritating to eyes, respiratory system and skin.

Safety Phrases:
     S 16 Keep away from sources of ignition - No smoking.
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 29 Do not empty into drains.

WGK (Water Danger/Protection)
     CAS# 75-31-0: 2
Canada - DSL/NDSL
     CAS# 75-31-0 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B2, E, D1B.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 75-31-0 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 6/17/1999
Revision #5 Date: 3/16/2007

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.