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Section 1 - Chemical Product and Company Identification |
MSDS Name: Pyridine
Catalog Numbers:
AC131780000, AC131780051, AC180220000, AC180220040, AC180222500,
AC180225000, AC290860000, AC290860010, AC290860025, AC290861000,
AC339420000, AC339420010, AC339421000, AC364420000, AC364420010,
AC364421000, AC386560000, AC386560010, AC386560250, AC386562500,
AC418530000, AC418530010, AC418540000, AC418540010, AC418540025,
AC61044019, AC61044050, AC61044050, AC61044115, AC61044115,
AC61044200, 13178-0010, 13178-0025, 13178-0500, 18022-0010, 18022-0250,
41853-2500, 41854-5000, 61044-0010, 61044-1000, 61099-1000, BP1155-500,
BP1155RS-50, BP2622-100, NC9154755, NC9788809, P367-1, P368-1, P368-4,
P368-500, P368J-500, P368S-4, P368SS-200, P369-4, S80152
Synonyms:
Azabenzene; Azine.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 110-86-1 |
Pyridine |
100 | 203-809-9 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: colorless to light yellow liquid. Flash Point: 17 deg C.
Danger! Causes severe eye and skin irritation with
possible burns. Flammable liquid and vapor.
Causes respiratory tract irritation. Stench. May be harmful if
swallowed, inhaled, or absorbed through the skin. May cause central
nervous system depression.
Target Organs: Blood, kidneys, central nervous
system, liver, eyes, skin, mucous membranes.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye
burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the
skin. Effects may be delayed. May cause smarting of the skin and
first-degree burns on short exposure. Substance is readily absorbed
through the skin. Pyridine was determined not to be a skin sensitizer
in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause liver and kidney damage. May cause central
nervous system depression, characterized by excitement, followed by
headache, dizziness, drowsiness, and nausea. Advanced stages may
cause collapse, unconsciousness, coma and possible death due to
respiratory failure. May cause effects similar to those for
inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. May cause respiratory tract irritation. Prolonged exposure
may result in dizziness and general weakness. Other symptoms
reported with acute exposure to pyridine include nervousness,
insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic
inhalation and ingestion may cause effects similar to those of acute
inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt
clinical symptoms can cause liver damage and repeated low-level
exposures can cause cirrhosis. Feeding studies in rats produced
blood effects like changes in clotting factors.
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Section 4 - First Aid Measures
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Eyes:
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash
clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion. Use water spray to keep
fire-exposed containers cool. Containers may explode in the heat of
a fire. Flammable liquid and vapor. Vapors are heavier than air and
may travel to a source of ignition and flash back. Vapors can spread
along the ground and collect in low or confined areas.
Extinguishing Media:
Solid streams of water may be ineffective and spread material. Use
water spray, dry chemical, "alcohol resistant" foam, or carbon
dioxide.
Flash Point: 17 deg C ( 62.60 deg F)
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Explosion Limits, Lower:1.8%
Upper: 12.4%
NFPA Rating:
(estimated) Health: 3; Flammability: 3; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation.
Prevent spreading of vapors through sewers, ventilation systems and
confined areas. Evacuate unnecessary personnel. Approach spill from
upwind. Use water spray to cool and disperse vapors, protect
personnel, and dilute spills to form nonflammable mixtures. Control
runoff and isolate discharged material for proper disposal.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Do not get in eyes, on skin, or on clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Keep away from heat, sparks
and flame. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames. Do not
breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from sources of ignition. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from
incompatible substances. Flammables-area. Isolate from oxidizing
materials and acids.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower. Ventilation
fans and other electrical service must be non-sparking and have an
explosion-proof design.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Pyridine
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1 ppm TWA
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5 ppm TWA; 15 mg/m3 TWA 1000 ppm IDLH
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5 ppm TWA; 15 mg/m3 TWA
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OSHA Vacated PELs:
Pyridine:
5 ppm TWA; 15 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: colorless to light yellow
Odor: strong odor - fish-like - penetrating odor - nauseating - stench
pH: 8.5 (0.2 M aq soln)
Vapor Pressure: 18 mm Hg @ 20 deg C
Vapor Density: 2.73 (Air=1)
Evaporation Rate:Not available.
Viscosity: 0.95 mPa s 20 deg C
Boiling Point: 115 deg C
Freezing/Melting Point:-42 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:.9780
Molecular Formula:C5H5N
Molecular Weight:79.1
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 110-86-1:
UR8400000
LD50/LC50:
CAS# 110-86-1:
Dermal, guinea pig:
LD50 = 1 gm/kg;
Draize test,
rabbit, skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = 28500
mg/m3/1H;
Oral, mouse: LD50 = 1500
mg/kg;
Oral, rat: LD50 = 891
mg/kg;
Skin, rabbit: LD50 = 1121
mg/kg;
.
Inhalation, rat: LC50 = 28500 mg/m3/1H; Skin, guinea pig: LD50 = 1
gm/kg.
Carcinogenicity:
CAS# 110-86-1:
- ACGIH:
A3 - Confirmed animal carcinogen with unknown relevance to humans
- California:
carcinogen, initial date 5/17/02
- NTP:
Not listed.
- IARC:
Not listed.
Epidemiology:
No information found
Teratogenicity:
Pyridine caused muscle/skeletal effects when injected into
developing chickens but was not teratogenic in frogs at
sublethal doses. The relevance of these studies to human
reproduction is unclear.
Reproductive Effects:
No information found
Mutagenicity:
Pyridine's mutagenicity potential is equivocal. It was
reported to be both positive and negative in Salmonella
typhimurium strains. It was not mutagenic in tests for
chromosome aberrations, but did give weak positive results
in tests that detect sister chromatid exchanges.
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through
No data available.
Environmental:
Terrestrial: Should have very high mobility. It is adsorbed to acid
clay to a moderate extent. Complete degradation in one soil occurred
in less than 8 days. Aquatic: Should biodegrade after an acclimation
period and can also be lost through volatilization. Atmospheric:
Exists in the vapor phase based on a vapor pressure of 20.80 mm Hg
and react slowly with photochemically produced hydroxy radicals with
experimental half-lives of 32 and 16 days in clean and moderately
polluted atmospheres, respectively. Bioconcentration in aquatic
organisms should not be significant.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 110-86-1: waste
number U196.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
PYRIDINE |
PYRIDINE |
| Hazard Class: |
3 |
3 |
| UN Number: |
UN1282 |
UN1282 |
| Packing Group: |
II |
II |
| Additional Info: | | FLASHPOINT 17C |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 110-86-1 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 110-86-1: Effective 10/4/82, Sunset 10/4/92
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 110-86-1: immediate, delayed, fire.
Section 313
This material contains Pyridine
(CAS# 110-86-1, 100%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 110-86-1 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Pyridine, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with skin and if
swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 28A After contact with skin, wash immediately with plenty of water
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WGK (Water Danger/Protection)
CAS# 110-86-1: 2
Canada - DSL/NDSL
CAS# 110-86-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 110-86-1 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 4/28/1998
Revision #12 Date: 2/11/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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