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Section 1 - Chemical Product and Company Identification |
MSDS Name: Propionitrile, 99%
Catalog Numbers:
AC180890000, AC180890050, AC180891000, AC180895000, AC9621447, AC9621448,
XXAC18089-11, XXAC18089-19, XXAC18089-26
Synonyms:
Cyanoethane; Ethyl cyanide; Hydrocyanic ether; Propionic nitrile.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 107-12-0 |
Propionitrile |
99 | 203-464-4 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: clear, colorless liquid. Flash Point: 6 deg C.
Danger! May be fatal if swallowed.
Flammable liquid and vapor. Causes eye, skin, and
respiratory tract irritation. Harmful if absorbed through skin or if
inhaled.
Target Organs: Respiratory system, eyes, skin.
Potential Health Effects
Eye:
Vapors cause eye irritation.
Skin:
Causes skin irritation. Harmful if absorbed through the skin.
Ingestion:
May be fatal if swallowed. Contains cyanide.
Inhalation:
Harmful if inhaled. Vapors may cause dizziness or suffocation. Vapor
or mist is irritating to the mucous membranes and upper respiratory
tract.
Chronic:
May cause cyanosis - a blue-gray coloring of the skin and lips
caused by a lack of oxygen. Massive doses may produce, without
warning, sudden loss of consciousness and prompt death from
respiratory arrest.
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. Do NOT use mouth-to-mouth resuscitation. Administer
oxygen. If breathing has ceased apply artificial respiration using
oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.
Antidote:
Always have a cyanide antidote kit on hand when working with cyanide
compounds. Get medical advice to use. The combination of sodium
thiosulfate and hydroxycobalamin has been used as an effective
antidote.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a
fire, irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Will burn if involved in a fire. Use
water spray to keep fire-exposed containers cool. Water may be
ineffective. Material is lighter than water and a fire may be spread
by the use of water. Containers may explode in the heat of a fire.
Flammable liquid and vapor. Vapors may be heavier than air. They
can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Do NOT use water directly on fire. Use water
spray to cool fire-exposed containers. Use foam, dry chemical, or
carbon dioxide. Water may be ineffective. Do NOT use straight streams
of water. Use water spray, dry chemical, carbon dioxide, or
appropriate foam.
Flash Point: 6 deg C ( 42.80 deg F)
Autoignition Temperature: 510 deg C ( 950.00 deg F)
Explosion Limits, Lower:3.10 vol %
Upper: .00 vol %
NFPA Rating:
(estimated) Health: 4; Flammability: 3; Instability: 1
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Keep away from heat, sparks
and flame. Do not get on skin or in eyes. Do not ingest or inhale.
Use with adequate ventilation. Wash clothing before reuse. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty
containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Flammables-area.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Propionitrile
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none listed
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6 ppm TWA; 14 mg/m3 TWA
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none listed
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OSHA Vacated PELs:
Propionitrile:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: clear, colorless
Odor: Pleasant, ethereal-sweetish odor
pH: Not available.
Vapor Pressure: 40 mm Hg @ 23 deg C
Vapor Density: 1.9 (air=1)
Evaporation Rate:Not available.
Viscosity: 0.44 mPas 20 deg C
Boiling Point: 97 deg C @ 760 mm Hg
Freezing/Melting Point:-93 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:.7720 g/cm3
Molecular Formula:C3H5N
Molecular Weight:55.08
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong acids, strong
bases.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 107-12-0:
UF9625000
LD50/LC50:
CAS# 107-12-0:
Draize test,
rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 500 mg/24H
Mild;
Inhalation, mouse: LC50 =
163 ppm/1H;
Oral, mouse: LD50 =
35797 ug/kg;
Oral, rat: LD50 = 39
mg/kg;
Skin, rabbit: LD50 = 210
uL/kg;
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Carcinogenicity:
CAS# 107-12-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information available.
Teratogenicity:
No information available.
Reproductive Effects:
Oral, rat: TDLo = 1120 mg/kg (female 6-19 days after
conception).; Inhalation, rat: TCLo = 100 ppm/6H (female
6-20 days after conception).; Intraperitoneal, hamster:
TDLo = 238 mg/kg (female 8-20 days after conception).
Mutagenicity:
Sex chromosome loss and nondisjunction: Inhalation,
Drosophil melanogaster = 51 ppm and Saccharomyces
cerevisiae = 15100 mg/L.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
Estimated BCF Value = 0.78. This value suggests that propionitrile is
not expected to bioconcentrate in aquatic organisms. Estimated Koc
Value = 1.2. This suggests that it will not be expected to adsorb
significantly to soil.
Environmental:
No information available.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: CAS# 107-12-0: waste number
P101.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
PROPIONITRILE |
PROPIONITRILE |
| Hazard Class: |
3 |
3(6.1) |
| UN Number: |
UN2404 |
UN2404 |
| Packing Group: |
II |
II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 107-12-0 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 107-12-0: 10 lb final RQ; 4.54 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 107-12-0: 500 lb TPQ
SARA Codes
CAS # 107-12-0: immediate, fire.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 107-12-0 can be found on the
following state right to know lists: New Jersey, Pennsylvania,
Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T F
Risk Phrases:
R 11 Highly flammable.
R 23/24/25 Toxic by inhalation, in contact with skin and if
swallowed.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 27 Take off immediately all contaminated clothing.
S 33 Take precautionary measures against static discharges.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 9 Keep container in a well-ventilated place.
WGK (Water Danger/Protection)
CAS# 107-12-0: 1
Canada - DSL/NDSL
CAS# 107-12-0 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D1A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 107-12-0 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 12/08/1998
Revision #4 Date: 3/15/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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