SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/JUN/2005
Date Updated: 21/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name GENTAMICIN SULFATE, MEETS USP TESTING
SPECIFICATIONS
Product Number G1914
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
GENTAMICIN SULFATE, MEETS USP 1405-41-0 215-778-9 None
TESTING SPECS.
Synonyms Garamycin * Genoptic * Genoptic S.O.P. *
Gentalline * Gentamycin sulfate * GM sulfate *
NSC-82261 * Refobacin * Sch 9724
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause sensitization by inhalation and skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing dust. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
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Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: LY2625000
ACUTE TOXICITY
LD50
Oral
Rat
> 5000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Skin and Appendages: Other: Hair.
LD50
Intraperitoneal
Rat
630 MG/KG
Remarks: Behavioral:Muscle contraction or spasticity. Lungs,
Thorax, or Respiration:Other changes.
LD50
Subcutaneous
Rat
873 MG(BASE)/KG
LD50
Intravenous
Rat
96 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
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righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Lungs, Thorax, or Respiration:Respiratory stimulation.
LD50
Intramuscular
Rat
384 MG/KG
LD50
Oral
Mouse
> 11269 mg/kg
LD50
Intraperitoneal
Mouse
245 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Convulsions or effect on seizure
threshold. Lungs, Thorax, or Respiration:Respiratory stimulation.
LD50
Subcutaneous
Mouse
478 MG/KG
LD50
Intravenous
Mouse
47 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Intramuscular
Mouse
250 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Lungs, Thorax, or Respiration:Respiratory
stimulation.
LD50
Intracerebral
Mouse
17300 UG/KG
Remarks: Peripheral Nerve and Sensation:Sensory change involving
peripheral nerve. Sense Organs and Special Senses (Nose, Eye,
Ear, and Taste):Eye:Etosis. Behavioral:Convulsions or effect on
seizure threshold.
LD50
Subcutaneous
Guinea pig
600 MG/KG
SENSITIZATION
Sensitization: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals. Causes
photosensitivity. Exposure to light can result in allergic
reactions resulting in dermatologic lesions, which can vary from
sunburnlike responses to edematous, vesiculated lesions, or
SIGMA - G1914 www.sigma-aldrich.com Page 4
bullae
SIGNS AND SYMPTOMS OF EXPOSURE
Aminoglycosides are associated with significant nephrotoxicity
and/or ototoxicity. Exposure can cause: Nausea, headache, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Aminoglycosides are associated with significant nephrotoxicity
and/or ototoxicity. Ears. Kidneys. Nerves.
CHRONIC EXPOSURE - MUTAGEN
Rat
70 MG/KG
Intraperitoneal
7D
DNA damage
Rat
9600 UG/KG
Unreported
8D
sperm
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 660 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-15D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Urogenital system.
Species: Rat
Dose: 375 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (14-18D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Effects on Newborn: Growth statistics (e.g., reduced weight
gain).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 660 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15-20D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
12 - Ecological Information
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No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 42/43
May cause sensitization by inhalation and skin contact.
S-PHRASES: 45 36/37/39 22
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). Wear suitable
protective clothing, gloves, and eye/face protection. Do not
breathe dust.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
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Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D or manufacturing use. Not for prescription compound or
other uses.
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