CAP A SOLUTION MSDS
MATERIAL SAFETY DATA SHEET
Transgenomic, Inc. Effective Date: 01 Dec 2003
12325 Emmet Street Document No.: MSD-17-1234-XX
Omaha, NE 68164 Revision No.: 1
Emergency Phone: 800-424-9300
(CHEMTREC 24hr)
SECTION 1. CHEMICAL IDENTIFICATION
CATALOG #: 17-1234-XX
NAME: CAP A SOLUTION
SECTION 2. COMPOSITION/INFORMATION ON INGREDIENTS
CAS#: 75-05-8 ACETONITRILE, ~80%
MF: CH3CN mw: 41.06
TRADE NAME: Ethanenitrile; Methyl Cyanide; Cyanomethane; Ethyl Nitrile
EC NUMBER (EINECS): 200-835-2
EC INDEX NUMBER: 608-001-00-3
CAS#: 616-47-7 1-METHYL-1H-IMIDAZOLE, ~20%
MF: CH3C3H3N2 mw: 82.11
TRADE NAME: Imidazole; 1-Methylimidazole; N-Methylimidazole; Oxalmethylene.
EC NUMBER (EINECS): 210-484-7
EC INDEX NUMBER: 613-035-00-7
UN1760
RTECS: NI7000000
SECTION 3. HAZARDS IDENTIFICATION
LABEL PRECAUTIONARY STATEMENTS: FLAMMABLE; CORROSIVE.
ROUTES OF ENTRY: INHALATION, ABSORPTION AND INGESTION.
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CAP A SOLUTION MSDS
NFPA Ratings (SCALE 0-4): HEALTH=2 FIRE=3 REACTIVITY=1
MAJOR HEALTH HAZARDS: Respiratory tract irritation, eye irritation, skin irritation,
and central nervous system depression.
PHYSICAL HAZARDS: Extremely Flammable liquid and vapor. Vapor may cause flash
fire.
POTENTIAL HEALTH EFFECTS:
-INHALATION:
Short Term Exposure: Irritation, nausea, changes in blood pressure, vomiting,
drowsiness, dizziness, wheezing, headache, symptoms of drunkenness,
disorientation, suffocation, convulsions and coma.
Long Term Exposure: Irritation, nosebleed, liver damage, reproductive effects,
brain damage, lung damage and coma.
-SKIN CONTACT: Irritation, may cause burns, same effects reported in short term
inhalation.
-EYE CONTACT: Irritation and tearing with possible eye damage.
-INGESTION: Irritation, nausea, vomiting, diarrhea, lung congestion, stomach pain with
possible liver and kidney damage.
CARCINOGEN STATUS:
-OSHA: No.
-NTP: No.
-IARC: No.
SECTION 4. FIRST-AID MEASURES
SEEK MEDICAL ASSISTANCE FOR ANY OVEREXPOSURE.
INHALATION: Remove victim to uncontaminated area. Get medical attention
immediately.
SKIN: Wash thoroughly with soap and water.
EYES: Immediately flush thoroughly with water for at least 15 minutes.
INGESTION: Contact local Poison Control Center or physician immediately. Never
give anything by mouth to an unconscious person.
SECTION 5. FIRE FIGHTING MEASURES
SEVERE FIRE HAZARD.
EXTINGUISHING MEDIA: Alcohol resistant foam, carbon dioxide, regular dry
chemical or water.
SPECIAL FIREFIGHTING PROCEDURES: Wear self璫ontained breathing apparatus
and protective clothing to prevent contact with skin and eyes. Water may be ineffective.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Hazardous polymerization may occur
with a heat source. Vapor/air mixtures are explosive. The vapor is heavier than air.
Vapors or gases may ignite at distant sources and flash back.
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CAP A SOLUTION MSDS
FLASH POINT: 6癈 cc
LOWER FLAMMABLE LIMIT: 4.4%
UPPER FLAMMABLE LIMIT: 16%
FLAMMABILITY CLASS (OSHA): IB
SECTION 6. ACCIDENTAL RELEASE MEASURES
Evacuate all unnecessary personnel. Wear a respirator, chemical safety goggles, rubber
boots and rubber gloves. Turn off all sources of ignition. Absorb with sand or
other non-combustible material and place in a closed container. Wash spill site with
soapy water.
Notify Local Emergency Planning Committee and State Emergency Response
Commission for releases greater than or equal to RQ (U.S. SARA Section 304).
If release occurs in the U.S. and is reportable under CERCLA Section 103, notify the
National Response Center at (800) 424-8802 (USA) or (202) 426-2675 (USA). Pyridine
is subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Prop
65). Keep out of water supplies and sewers.
SECTION 7. HANDLING AND STORAGE
Store and handle in accordance with all current regulations and standards. Keep separated
from incompatible substances. Store with flammable liquids. Store in a cool dry place.
Subject to storage regulations: U.S. OSHA 29 CFR 1910.106.
SECTION 8. EXPOSURE CONTROLS AND
PERSONAL PROTECTION
EXPOSURE LIMIT for ACETONITRILE:
40 ppm OSHA TWA
60 ppm OSHA STEL
40 ppm ACGIH TWA
60 ppm ACGIH STEL
20 NIOSH recommended TWA 10 hours
40 ppm UK OES TWA (skin)
60ppm UK OES STEL (skin)
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CAP A SOLUTION MSDS
EXPOSURE LIMIT for IMIDAZOLE: No Occupational Exposure Limits Established.
MECHANICAL EXHAUST REQUIRED
CHEMICAL SAFETY GOGGLES.
NIOSH/MSHA-APPROVED RESPIRATOR.
SAFETY SHOWER AND EYE BATH.
COMPATIBLE CHEMICAL-RESISTANT GLOVES (RUBBER).
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
KEEP TIGHTLY CLOSED.
FLAMMABLE.
CORROSIVE.
STORE IN A COOL DRY PLACE.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE: Colorless liquid.
BOILING POINT: No Data.
For 100% ACN: 81癈
For 100% IMIDAZOLE: 195癈
WATER SOLUBILITY: Water Soluble.
SPECIFIC GRAVITY: No Data.
For 100% ACN: 0.786 g/mL
SECTION 10. STABILITY AND REACTIVITY
REACTIVITY: May form explosive peroxides. Avoid prolonged storage or contact with
air, light or storage and use above room temperature.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition.
Minimize contact with material. Avoid inhalation. Keep out of water supplies
and sewers.
INCOMPATIBILITIES: Acids, metals, bases, oxidizing materials, combustible materials
and oxidizing materials.
HAZARDOUS POLYMERIZATION: MAY OCCUR IF LEFT EXPOSED TO AIR OR
HEAT FOR PROLONGED TIME.
DECOMPOSITION PRODUCTS: Oxides of carbon and nitrogen.
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CAP A SOLUTION MSDS
SECTION 11. TOXICOLOGICAL INFORMATION
To the best of our knowledge, the chemical, physical and toxicological properties have
not been thoroughly investigated.
CARCINOGEN STATUS: A4-Not classifiable as a Human Carcinogen.
LOCAL EFFECTS: Corrosive by inhalation, skin and eye.
ACUTE TOXICITY LEVEL:
MODERATELY TOXIC: Ingestion, inhalation and dermal absorption.
TARGET ORGANS: Central Nervous System and Immune System (sensitizer).
TUMORIGENIC DATA: No Data
MUTAGENIC DATA: No Data
REPRODUCTIVE EFFECTS DATA: No Data
TOXICITY DATA: No Data
HEALTH EFFECTS:
INHALATION:
For ACETONITRILE (this solution contains ~80%): Inhalation of
500 ppm for a short duration may cause irritation of the nose and
throat. Humans exposed to 160 ppm for 4 hours experienced
delayed symptoms of slight flushing of the face and slight
bronchial tightness. A burning sensation, wheezing and laryngitis
may also occur.
For 100% IMIDAZOLE (this solution contains ~20%): May cause
severe irritation of the respiratory tract with coughing, choking,
pain and possible burns of the mucous membranes. In some cases,
pulmonary edema may develop, which may be fatal. Symptoms
may include tightness of the chest, dyspnea, frothy sputum,
cyanosis and dizziness.
SKIN CONTACT:
For ACETONITRILE: Contact may cause irritation. Skin absorption may
occur resulting in systemic toxicity as detailed in inhalation above.
Repeated or prolonged exposure may cause dermatitis.
For 100% IMIDAZOLE (this solution contains ~20%): Direct contact
with liquid may cause severe irritation, pain or burns. Repeated
exposure may cause dermatitis.
EYE CONTACT:
For ACETONITRILE: Vapors may cause irritation, blurred vision
and tearing. Repeated or prolonged exposure to irritants may cause
conjunctivitis.
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CAP A SOLUTION MSDS
For 100% IMIDAZOLE (this solution contains ~20%): Direct contact
with liquid may cause severe irritation, pain or burns. Repeated or
prolonged exposure may cause conjunctivitis.
INGESTION:
For ACETONITRILE: Ingestion of sufficient amounts may cause
systemic toxicity as detailed in inhalation. Reproductive effects
have been reported in animals.
For 100% IMIDAZOLE (this solution contains ~20%): May
cause immediate pain and severe burns of the mucous membranes.
Swallowing and speech may be difficult at first and ten almost
impossible. The effects on the esophagus and gastrointestinal tract
may range from irritation to severe corrosion. Edema of the
epiglottis and shock may occur.
SECTION 12. ECOLOGICAL INFORMATION
FOR ACETONITRILE:
INVERTEBRATE TOXICITY: 0.024-0.199 礸/L for 4-72 hrs (residue)
Bentnosed clam (Macoma nasuta)
FISH TOXICITY: 1g/L for 96hrs LC50 (Mortality) Fathead minnow
(Pimephales promelas).
No Data for IMIDAZOLE.
SECTION 13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
SECTION 14. TRANSPORTATION INFORMATION
U.S. DOT 49 CFR 172.101
PROPER SHIPPING NAME: Flammable liquid, corrosive, n.o.s..
UN2924
CLASS 3; Subsidiary Risk 8
PACKAGING GROUP: II
LABELS: Flammable Liquid 3 & Corrosive (with out the numeral 8).
AIR TRANSPORT (IATA/ICAO):
PROPER SHIPPING NAME: Flammable liquid, corrosive, n.o.s.
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CAP A SOLUTION MSDS
UN2924
CLASS 3; Subsidiary Risk 8
PACKAGING GROUP: II
LABELS: Flammable Liquid 3 & Corrosive (with out the numeral 8).
MARITIME TRANSPORT:
IMDG CLASS: 3
PACKAGING GROUP: II
UN2924
LABELS: Flammable Liquid 3 & Corrosive (with out the numeral 8).
SECTION 15. REGULATORY INFORMATION
TSCA INVENTORY STATUS: Yes (ACN & Imidazole).
TSCA 12 (b) EXPORT NOTIFICATION: Not Listed.
CERCLA SECTION 103 (40CFR302.4): Yes, ACN, 5000 lbs.
SARA SECTION 302 (40CFR355.30): No.
SARA SECTION 304 (40CFR355.40): No.
SARA SECTION 313 (40CFR372.65) Yes (ACN)
SARA HAZARD CATEGORIES, SARA SECTIONS 311/312 (40CFR370.21):
ACUTE: Yes, (ACN, Imidazole).
CHRONIC: No.
FIRE: Yes, (ACN, Imidazole).
REACTIVE: No.
SUDDEN RELEASE: No.
OSHA PROCESS SAFETY (29CFR1910.119): No.
STATE REGULATIONS: No
CANADIAN REGULATIONS:
WHMIS CLASSIFIACTIONS: Not Determined
SECTION 16. OTHER INFORMATION
The above information is believed to be correct and shall be used only as a guide. The
information may be inclusive. Transgenomic, Inc. shall not be held liable for any
damage resulting from handling or from contact with the above material.
2032 CONCOURSE DRIVE 12325 EMMET STREET THE QUADRANGLE,CREWE HALL WESTON RD. 8-14-21 NISHI-SHINJUKU SHINJUKU-KU
SOEI BUILDING, 4TH FLOOR
SAN JOSE, CA 95131 OMAHA, NE 68164 CREWE, CHESHIRE, UK CW1 6UZ
ph 408.432.3230 ph 402.452.5400 ph (44) 1270.259.359 TOKYO, HONSHU, JAPAN 160-0023
fax 408.432.3231 fax 402.452.5401 fax (44) 1270.259.358 ph +81-3-5338.0181
fax +81-3-5338.0184
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