Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
Section 1 - Chemical Product and Company Identification
MSDS Name:
Bovine Thrombin 200/500
Catalog Numbers:
100601, 100606, 176297, 200601, 200606, 206689, 23176297, 23306291, 23306291DEM, 250601, 250606, 300606,
306291, CMS176297, CMS306291, PH100601
Synonyms:
Fibrinogen Reagent (Bovine) .
Company Identification:
Fisher Diagnostics
Fisher Scientific Company LLC
8365 Valley Pike
Middletown, VA 22645-0307
Company Phone Number:
(800) 528-0494
Emergency Phone Number:
(800) 528-0494
CHEMTREC Phone Number:
800-424-9300
CHEMTREC (International):
703-527-3887
Section 2 - Composition, Information on Ingredients
EINECS/
CAS# Chemical Name: ELINCS
Percent
77-86-1 Tris (hydroxymethyl) aminomethane 1.49% 201-064-4
Not available BSA Fraction V 0.9% Not available
7647-14-5 Sodium chloride 0.89% 231-598-3
9002-04-4 Bovine Thrombin 0.8-1.2% 232-648-7
10043-52-4 Calcium chloride 0.144 % 233-140-8
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: clear, colorless liquid
Caution! Each unit of source material used in the preparation of this product has been
tested by an FDA licensed method and found non-reactive for HBsAg and negative for
antibodies to HIV and HCV. However, no known test method can offer complete assurance
that products derived from human blood will not transmit hepatitis, AIDS, or other infectious
diseases. This product, like all materials of human origin, should be handled as potentially
infectious biological material. Causes eye irritation. May be absorbed through intact skin.
May cause skin irritation. May cause respiratory and digestive tract irritation.
Target Organs: none.
Potential Health Effects
Eye:
Causes eye irritation. Contact may cause transient eye irritation.
Skin:
Low hazard for usual industrial handling. May be absorbed through the skin.
Ingestion:
Ingestion of large amounts may cause gastrointestinal irritation. Low hazard for usual industrial handling.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.
Section 4 - First Aid Measures
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical
aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
Section 5 - Fire Fighting Measures
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or
equivalent), and full protective gear.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.
Autoignition Temperature:
Not applicable.
Explosion Limits:
Lower: Not available. Upper: Not available.
Flash Point:
Not applicable.
NFPA Rating:
(estimated) Health: 1; Flammability: 0; Reactivity: 0
Section 6 - Accidental Release Measures
General Information:
Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills
immediately, observing precautions in the Protective Equipment section.
Section 7 - Handling and Storage
Handling:
Wash thoroughly after handling. Wash thoroughly after handling. Remove contaminated clothing and wash before
reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool place in the original container and protect from sunlight. Keep container closed when not in use.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Good general ventilation should be sufficient to control airborne levels.
Exposure Limits
Chemical Name: ACGIH NIOSH OSHA
None of the components None of the components None of the components
Tris (hydroxymethyl)
are on this list. are on this list. are on this list.
aminomethane
None of the components None of the components None of the components
Sodium chloride
are on this list. are on this list. are on this list.
None of the components None of the components None of the components
Bovine Thrombin
are on this list. are on this list. are on this list.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
None of the components None of the components None of the components
Calcium chloride
are on this list. are on this list. are on this list.
OSHA Vacated PELs
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection
regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or
other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Color: clear, colorless
Odor: Odorless.
pH: No information found
Vapor Pressure: No information found
Vapor Density: No information found
Evaporation Rate: No information found
Viscosity: No information found
Boiling Point: Not available.
Freezing/Melting Point: No information found
Decomposition Temperature: No information found
Solubility in water: Soluble in water.
Specific Gravity/Density: No information found
Molecular Formula: Not applicable.
Molecular Weight: No information found
Section 10 - Stability and Reactivity
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials
Strong oxidants.
Hazardous Decomposition Products
No data available.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
Hazardous Polymerization
Has not been reported
Section 11 - Toxicological Information
RTECS:
CAS# 77-86-1: TY2900000.
CAS# 7647-14-5: VZ4725000.
CAS# 9002-04-4: XO8950000.
CAS# 10043-52-4: EV9800000.
LD50/LC50:
CAS# 77-86-1:
Oral, rat: LD50 = 5900 mg/kg.
CAS# 7647-14-5:
Draize test, rabbit, eye: 100 mg Mild
Draize test, rabbit, eye: 100 mg/24H Moderate
Draize test, rabbit, eye: 10 mg Moderate
Draize test, rabbit, skin: 50 mg/24H Mild
Draize test, rabbit, skin: 500 mg/24H Mild
Inhalation, rat: LC50 = >42 gm/m3/1H
Oral, mouse: LD50 = 4 gm/kg
Oral, rat: LD50 = 3000 mg/kg
Skin, rabbit: LD50 = >10 gm/kg.
CAS# 9002-04-4:
No information foundCAS# 10043-52-4:
Oral, mouse: LD50 = 1940 mg/kg
Oral, rabbit: LD50 = 1384 mg/kg
Oral, rat: LD50 = 1 gm/kg.
Carcinogenicity:
CAS# 77-86-1: Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65.
CAS# 7647-14-5: Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65.
CAS# 9002-04-4: Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65.
CAS# 10043-52-4: Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
No information found
Reproductive:
No information found
Mutagenicity:
No information found
Neurotoxicity:
No information found
Other:
See actual entry in RTECS for complete information.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
Section 12 - Ecological Information
No information found
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Part 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
RCRA P Series Wastes
None of the components are on this list.
RCRA U Series Wastes
None of the components are on this list.
Section 14 - Transport Information
US DOT Canadian TDG
Proper Shipping No information found No information
found
Name:
Hazard Class:
UN Number:
Packing Group:
Section 15 - Regulatory Information
US Federal
TSCA
CAS# 77-86-1 is listed on the TSCA Inventory.
CAS# 7647-14-5 is listed on the TSCA Inventory.
CAS# 9002-04-4 is listed on the TSCA Inventory.
CAS# 10043-52-4 is listed on the TSCA Inventory.
Health and Safety Reporting List
None of the components are on this list.
Chemical Test Rules
None of the components are on this list.
TSCA Section 12b
None of the components are on this list.
TSCA Significant New Use Rule (SNUR)
None of the components are on this list.
CERCLA Hazardous Substances and corresponding RQs
None of the components are on this list.
SARA Section 302 Extremely Hazardous Substances
None of the components are on this list.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
SARA Hazard Categories
CAS# 77-86-1: acute.
CAS# 7647-14-5: acute.
CAS# 10043-52-4: acute, chronic, reactive.
CERCLA/SARA Section 313
None of the components are on this list.
Clean Air Act - Hazardous Air Pollutants (HAPs)
None of the components are on this list.
Clean Air Act - Class 1 Ozone Depletors
None of the components are on this list.
Clean Air Act - Class 2 Ozone Depletors
None of the components are on this list.
Clean Water Act - Hazardous Substances
None of the components are on this list.
Clean Water Act - Priority Pollutants
None of the components are on this list.
Clean Water Act - Toxic Pollutants
None of the components are on this list.
OSHA - Highly Hazardous
None of the components are on this list.
US State
State Right to Know
California Regulations
CAS# 77-86-1: No information found
CAS# Not available: No information found
CAS# 7647-14-5: No information found
CAS# 9002-04-4: No information found
CAS# 10043-52-4: No information found
European/International Regulations
European Labelling in Accordance with EC Directives:
Hazard Symbols:
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 77-86-1: 1
CAS# Not available: No information found
CAS# 7647-14-5: 0
CAS# 9002-04-4: 1
CAS# 10043-52-4: 0
United Kingdom Occupational Exposure Limits
No information found
Canadian DSL/NDSL
CAS# 77-86-1 is listed on Canada's DSL List.
CAS# 7647-14-5 is listed on Canada's DSL List.
Print Date: 8/03/2007
ACC# 90142
Revision Date: 3/22/2006
Version: 4
Material Safety Data Sheet
Bovine Thrombin 200/500
CAS# 10043-52-4 is listed on Canada's DSL List.
Canadian WHMIS Classifications
No information found
Canadian Ingredient Disclosure List
CAS# 77-86-1 is not listed on Canada's Ingredient Disclosure List.
CAS# Not available is not listed on Canada's Ingredient Disclosure List.
CAS# 7647-14-5 is not listed on Canada's Ingredient Disclosure List.
CAS# 9002-04-4 is not listed on Canada's Ingredient Disclosure List.
CAS# 10043-52-4 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
Section 16 - Other Information
Color information has been
MSDS Creation Date: September 2, 1997
Revision Date: March 22, 2006
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of
merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should
make their own investigations to determine the suitability of the information for their particular purposes. In no event shall the company be liable for any
claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever
arising, even if the company has been advised of the possibility of such damages.
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