PowerVision & PowerVision+ Detection Systems (HRP/DAB)
Material Safety Data Sheet
1. PRODUCT AND COMPANY INFORMATION
Identification of the product
Product name: Catalogue code:
PowerVision+ Poly-HRP IHC Detection System PV6103, PV6104
PowerVision+ Poly-HRP IHC anti-Mouse Detection System PV6112, PV6113
PowerVision+ Poly-HRP IHC anti-Rabbit Detection System PV6118
PowerVision Homo Mouse Detection System (DAB) PV6134
Intended Use: Immunohistochemistry
Manufacturer / supplier identification
Company: Leica Biosystems Newcastle Ltd.
Balliol Business Park West
Benton Lane
Newcastle upon Tyne
NE12 8EW, UK.
Telephone: 0044 (0) 191 215 4242
Fax: 0044 (0) 191 215 1152
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 1 of 10
Component: Blocking, Post Blocking, Poly-HRP
Material Safety Data Sheet
2. COMPOSITION / INFORMATION ON INGREDIENTS
Component CAS# Percent Classification:
Composition Indications of Danger / R Phrases
Animal sera No data approx. 10% R20/21/22 R36/37/38
2-methyl-4-isothiazolin 2682-20-4 0.1% R36/37/38
-3-one
For indications of danger and R-phrases see Section 16.
3. HAZARDS IDENTIFICATION
This product is not classified as a dangerous preparation according to 1999/45/EC, 67/548/EEC, 2001/58/EC
directives and following amendments and modifications.
For additional information on toxicity, please refer to section 11.
4. FIRST AID MEASURES
Ingestion: If ingested, wash out mouth with water, provided person is conscious. Seek medical
advice immediately. Do not induce vomiting.
Inhalation: If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is
difficult, give oxygen. Seek medical advice immediately.
Skin: Immediately remove contaminated clothing and shoes. In case of skin contact, flush
with plenty of water for at least 15 minutes.
Eye: In case of contact with eyes, flush with plenty of water for at least 15 minutes. Assure
adequate flushing by separating the eyelids with fingers. Seek medical advice
immediately.
5. FIRE FIGHTING MEASURES
Autoignition Temp: N/A
Firefighting Protective
Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with
skin and eyes.
Specific Hazard(s): Thermal decomposition may produce toxic fumes.
6. ACCIDENTAL RELEASE MEASURES
Procedure(s) of Personal Precaution(s)
Wear enclosed footwear and chemical-resistant gloves.
Methods for Cleaning Up
Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site
after material pickup is complete.
7. HANDLING AND STORAGE
Handling: Avoid inhalation of vapor or mist. Avoid contact with eyes, skin, and clothing. Avoid
prolonged or repeated exposure.
Storage: Store at 2-8篊. Keep container tightly closed.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls: Safety shower and eye bath.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 2 of 10
Component: Blocking, Post Blocking, Poly-HRP
Material Safety Data Sheet
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical Appearance: Liquid Relative Density: No data
Color: Pale brown pH: No data
Odor: No data Flash Point: No data
Flammability: No data Solubility: Fully miscible with water
10. STABILITY AND REACTIVITY
Stability: Stable.
Materials to Avoid: Strong oxidising agents.
Hazardous Decomposition
Products: Nature of decomposition products not known.
11. TOXICOLOGICAL INFORMATION
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material is irritating to mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: May be harmful if swallowed.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly
investigated.
12. ECOLOGICAL INFORMATION
No data available.
13. DISPOSAL CONSIDERATIONS
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber.
Contact your local waste disposal authority for advice, or pass to a chemical disposal company. Rinse out
empty containers thoroughly before disposal.
14. TRANSPORTATION INFORMATION
This substance is considered to be non-hazardous for transport.
15. REGULATORY INFORMATION
This product is not classified as a dangerous preparation according to 1999/45/EC, 67/548/EEC, 2001/58/EC
directives and following amendments and modifications.
S-phrases: S36/37/39
Wear suitable protective clothing, gloves and eye/face protection.
EEC-No.: No data available.
Local regulations: No data available.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 3 of 10
Component: Blocking, Post Blocking, Poly-HRP
Material Safety Data Sheet
16. OTHER INFORMATION
Indications of danger: To the best of our knowledge no hazards are associated with the use of this product.
R-phrases: R20/21/22 R36/37/38
Harmful if inhaled, in contact with skin and if swallowed. Irritating to eyes respiratory
system and skin.
The information contained in this Material Safety Data Sheet is believed to be accurate but it is the responsibility
of the user or supplier to determine the applicability of the data to the formulation of necessary safety
precautions. Leica Biosystems Newcastle Ltd. shall not be held responsible for any damage resulting from the
use of the above product or the information contained in this Material Safety Data Sheet.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 4 of 10
Component: DAB Substrate
Material Safety Data Sheet
2. COMPOSITION / INFORMATION ON INGREDIENTS
Component CAS# Percent Classification:
Composition Indications of Danger / R Phrases
Acetic Acid 64-19-7 17% R 36/37/38
Hydrogen Peroxide 7722-84-1 1% R 36/37/38
Ethylenediaminetetraacetic
acid tetrasodium salt 13235-36-4 0.455% R 36/37/38
For indications of danger and R-phrases see Section 16.
3. HAZARDS IDENTIFICATION
According to 1999/45/EC, 67/548/EEC, 2001/58/EC directives and following amendments and modifications, the
preparation is classified as:
R 36/37/38
Irritating to eyes, respiratory system and skin
For additional information on toxicity, please refer to section 11.
4. FIRST AID MEASURES
Ingestion: If swallowed wash out mouth with water provided person is conscious. Call a
physician.
Inhalation: If inhaled, remove to fresh air. If breathing is difficult, give oxygen.
Skin: Immediately remove contaminated clothing and shoes. In case of skin contact, flush
with plenty of water for at least 15 minutes. Seek medical attention.
Eye: In case of contact with eyes, flush with plenty of water for at least 15 minutes. Assure
adequate flushing by separating the eyelids with fingers. Seek medical advice
immediately.
5. FIRE FIGHTING MEASURES
Autoignition Temp: N/A
Firefighting Protective
Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with
skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
6. ACCIDENTAL RELEASE MEASURES
Procedure(s) of Personal Precaution(s)
Wear enclosed footwear and chemical-resistant gloves.
Methods for Cleaning Up
Absorb on sand or vermiculite and place in closed containers for disposal. When spilled, the floor may be
slippery. Wipe up the spillage completely. Ventilate area and wash spill site after material pickup is complete.
7. HANDLING AND STORAGE
Handling: Do not breathe vapor. Avoid contact with eyes, skin and clothing. Avoid prolonged or
repeated exposure.
Storage: Keep tightly closed. Store at 2-8篊.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Component: DAB Substrate
Material Safety Data Sheet
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls: Safety shower and eye bath.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
General Hygiene: Wash contaminated clothing before reuse. Wash thoroughly after handling. Discard
contaminated shoes.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical Appearance: Liquid Relative Density: No data
Color: Colorless pH: No data
Odor: No data Flash Point: No data
Flammability: No data Solubility: No data
10. STABILITY AND REACTIVITY
Stability: Stable.
Conditions to Avoid: No data.
Materials to Avoid: Strong oxidizing agents.
Hazardous Decomposition
Products: Nature of decomposition products not known.
11. TOXICOLOGICAL INFORMATION
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly
investigated.
Conditions Aggravated by Exposure
No data.
Chronic Exposure Carcinogen
No data.
12. ECOLOGICAL INFORMATION
No data available.
13. DISPOSAL CONSIDERATIONS
Chemical residues are generally classified as special waste, and as such are covered by regulations which vary
according to location. Contact your local waste disposal authority for advice, or pass to a chemical disposal
company. Rinse out empty containers thoroughly before disposal.
14. TRANSPORTATION INFORMATION
Complete
Shipping Name: No data.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 6 of 10
Component: DAB Substrate
Material Safety Data Sheet
15. REGULATORY INFORMATION
This product is not classified as a dangerous preparation according to 1999/45/EC, 67/548/EEC, 2001/58/EC
directives and following amendments and modifications.
S-phrases: S 26 36/37/39 63/64
In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice. Wear suitable protective clothing, gloves, and eye/face protection. In case of
inhalation, remove casualty to fresh air. If swallowed, rinse mouth with water (only if
the person is conscious).
EEC-No.: No data available
Local regulations: No data available
16. OTHER INFORMATION
Risk Statements: R 36/37/38
Irritating to eyes, respiratory system and skin.
The information contained in this Material Safety Data Sheet is believed to be accurate but it is the responsibility
of the user or supplier to determine the applicability of the data to the formulation of necessary safety
precautions. Leica Biosystems Newcastle Ltd. shall not be held responsible for any damage resulting from the
use of the above product or the information contained in this Material Safety Data Sheet.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 7 of 10
Component: DAB Chromogen
Material Safety Data Sheet
2. COMPOSITION / INFORMATION ON INGREDIENTS
Component CAS# Percent Classification:
Composition Indications of Danger / R Phrases
3,3' diaminobenzidine
tetrahydrochloric acid 7411-49-6 2.5% Xn / R22, R36/37/38
Pyrocatechol 120-80-9 7.5% Xn / R21/22, R36/38
For indications of danger and R-phrases see Section 16.
3. HAZARDS IDENTIFICATION
Harmful in contact with skin and if swallowed. Irritating to eyes and skin.
4. FIRST AID MEASURES
Ingestion: If ingested, wash out mouth with water, provided person is conscious. Seek medical
advice immediately. Do not induce vomiting.
Inhalation: If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is
difficult, give oxygen. Seek medical advice immediately.
Skin: Immediately remove contaminated clothing and shoes. In case of skin contact, flush
with plenty of water for at least 15 minutes.
Eye: In case of contact with eyes, flush with plenty of water for at least 15 minutes. Assure
adequate flushing by separating the eyelids with fingers. Seek medical advice
immediately.
5. FIRE FIGHTING MEASURES
Autoignition Temp: N/A
Firefighting Protective
Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with
skin and eyes.
Specific Hazard(s): Thermal decomposition may produce toxic fumes.
6. ACCIDENTAL RELEASE MEASURES
Procedure(s) of Personal Precaution(s)
Wear enclosed footwear and chemical-resistant gloves.
Methods for Cleaning Up
Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site
after material pickup is complete.
7. HANDLING AND STORAGE
Handling: Avoid inhalation of vapor or mist. Avoid contact with eyes, skin, and clothing. Avoid
prolonged or repeated exposure.
Storage: Store at 2-8篊. Keep container tightly closed.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls: Safety shower and eye bath.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Component: DAB Chromogen
Material Safety Data Sheet
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical Appearance: Liquid Relative Density: No data
Color: Brown pH: No data
Odor: No data Flash Point: No data
Flammability: No data Solubility: Fully miscible with water
10. STABILITY AND REACTIVITY
Stability: Stable.
Materials to Avoid: Strong oxidising agents.
Hazardous Decomposition
Products: Nature of decomposition products not known.
11. TOXICOLOGICAL INFORMATION
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material is irritating to mucous membranes and upper respiratory tract. May be harmful
if inhaled.
Ingestion: May be harmful if swallowed.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly
investigated.
12. ECOLOGICAL INFORMATION
No data available.
13. DISPOSAL CONSIDERATIONS
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber.
Contact your local waste disposal authority for advice, or pass to a chemical disposal company. Rinse out
empty containers thoroughly before disposal.
14. TRANSPORTATION INFORMATION
This substance is considered to be non-hazardous for transport.
15. REGULATORY INFORMATION
This product is not classified as a dangerous preparation according to 1999/45/EC, 67/548/EEC, 2001/58/EC
directives and following amendments and modifications.
S-phrases: S26, 36/37/39
In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice. Wear suitable protective clothing, gloves and eye/face protection.
EEC-No.: No data available.
Local regulations: No data available.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 9 of 10
Component: DAB Chromogen
Material Safety Data Sheet
16. OTHER INFORMATION
Indications of danger: To the best of our knowledge no hazards are associated with the use of this product.
R-phrases: R20/21/22 R36/37/38
Harmful if inhaled, in contact with skin and if swallowed. Irritating to eyes respiratory
system and skin.
The information contained in this Material Safety Data Sheet is believed to be accurate but it is the responsibility
of the user or supplier to determine the applicability of the data to the formulation of necessary safety
precautions. Leica Biosystems Newcastle Ltd. shall not be held responsible for any damage resulting from the
use of the above product or the information contained in this Material Safety Data Sheet.
PV_MSDS_050.doc rev-A
Date Issued: 12/05/08
Page 10 of 10
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