Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
Praxair Material Safety Data Sheet
1. Chemical Product and Company Identification
Trade Name:
OXYFUME 12 OXYFUME 12
Product Name:
Product Use: Not available.
Chemical Name: Synonym:
OXYFUME Sterilant Mixture 12 Sterilant Mixture; 12-88
Chemical Formula: Chemical Family:
Mix. ethylene oxide & Not applicable.
dichlorodifluoromethane
Telephone: Emergencies: * 1-800-363-0042 Supplier Praxair Canada Inc.
/Manufacture: 1 City Centre Drive
Suite 1200
Mississauga, ON L5B 1M2
Phone: 905-803-1600
Fax: 905-803-1682
*Call emergency numbers 24 hours a day only for spills, leaks, fire, exposure, or accidents involving this product. For routine
information, contact your supplier or Praxair sales representative.
2. Composition and Information on Ingredients
INGREDIENTS % (VOL) CAS LD50 LC50 TLV-TWA
NUMBER (Species & (Rat, 4 hrs.) (ACGIH)
Routes)
1) Ethylene oxide 12 75-21-8 Not available. 1462 ppm 1 ppm
2) Dichlorodifluoromethane 88 75-71-8 Not available. Not available. 1000 ppm
3. Hazards Identification
Emergency Overview
WARNING! Flammable, high-pressure gas. May form explosive mixture with air. Can cause rapid suffocation. May cause
dizziness and drowsiness. Self-contained breathing apparatus may be required by rescue workers.
ROUTES OF EXPOSURE: Absorbed through skin. Eye contact. Inhalation. Ingestion.
THRESHOLD LIMIT VALUE: TLV-TWA Data from 2001 Guide to Occupational Exposure Values (ACGIH). TLV-TWAs should be
used as a guide in the control of health hazards and not as fine lines between safe and dangerous concentrations.
EFFECTS OF A SINGLE (ACUTE) OVEREXPOSURE:
INHALATION: Asphyxiant. Moderate concentrations may cause headaches, drowsiness, dizziness, stinging of the
nose and throat, excitation, rapid breathing, excess salivation, vomiting, and unconsciousness. Lack of
oxygen can kill. Causes irritation of the respiratory tract. Depending on the degree of exposure, there
may be coughing, chest tightness, nausea, diarrhea, weakness, cyanosis, loss of coordination,
convulsions and coma. May cause lung injury and the delayed onset of pulmonary edema.
SKIN CONTACT: A highly unlikely route of exposure. This product is a gas at normal temperature and pressure. Liquid
may cause frostbite. With liquid or solutions in water, there may occur a local erythema, edema, and
formation of vesicles. There may be a latent period of several hours prior to the onset of these signs.
Sustained contact with the skin is unlikely, but can cause headache, dizziness, nausea and vomiting.
SKIN ABSORPTION:
A dilute solution may penetrate skin, producing, a chemical burn.
SWALLOWING:
A highly unlikely route of exposure. Will cause severe irritation and ulceration of the mouth and throat,
abdominal pain, nausea, vomiting, collapse and coma. Frostbite of the lips and mouth may result from
contact with the liquid.
EYE CONTACT:
Severe irritation with corneal injury from liquid. Moderate irritation from high concentrations of vapour.
Copyright ?2001, Praxair Canada Inc. Page 1 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
EFFECTS OF REPEATED (CHRONIC) OVEREXPOSURE:
Ethylene Oxide: Allergic contact dermatitis may occur in a small proportion of exposed workers. In various reports involving
recurrent exposures to high concentrations of ethylene oxide vapour, peripheral neurotoxic effects, and, in some cases, indications
of central nervous system toxicity, where described resulting from gross overexposure. In most cases, there was marked
improvement on removal from further exposure. A few cases of cataract formation have increased incidence of abortions, the
laboratory findings indicated that if adverse reproductive effects are produced by ethylene oxide, these occur only at high exposure
concentrations. Several studies on ethylene oxide exposed workers have demonstrated an increased incidence of chromosomal
aberrations and sister chromatic exchanges; the relevance of such effects to human health hazards evaluation is currently
uncertain. OSHA considers that, at excess levels, Ethylene Oxide may present reproductive, mutagenic, genotoxic, neurologic and
sensitization hazards.
OTHER EFFECTS OF OVEREXPOSURE:
At very high concentrations may produce cardiac arrhythmias or arrest due to sensitization of the heart to adrenalin and
non-adrenalin. This mixture is an asphyxiant. Lack of oxygen can cause death.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE:
A knowledge of the available toxicology information and of the physical and chemical properties of the material suggests that
overexposure is unlikely to aggravate existing medical conditions.
CARCINOGENIC AND MUTAGENIC ASSESSMENT: Ethylene Oxide is considers by OSHA, IARC and NTP as a potential human
carcinogen and mutagen.
SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH HAZARD EVALUATION:
Ethylene oxide has been shown to product mutagenic and cytogenic effects in a variety of test systems.
Animals exposed to ethylene oxide vapour for up to two years have shown an increase in the incidence of certain malignant tumors
in comparison to nonexposed controls.
In humans, an increased occurrence of leukemia and stomach cancer has been reported by one group of investigators who pooled
results from three Swedish facilities producing or using ethylene oxide, among other materials. Based on experimental and
observational data ethylene oxide is a suspect cancer hazard, and should be treated as possible causing cancer in humans.
Laboratory studies with mice have shown that acute exposure to ethylene oxide vapour at concentrations of 3090 pppm and above
cause testicular injury as evidenced by concentrations-related increased embryonic deaths following the mating of exposed males
to nonexposed females (Dominant Lethal Test). Also, a one generation reproduction study in rats showed decreased numbers of
pups at 100 byt not at 33 ppm. Inhalation teratology studies have shown genotoxicity at 100 ppm and above, but no evidence for
birth defects.
CARCINOGENICITY:
Classified 1 (Proven for human.) by IARC, 1 (Clear evidence.) by NTP, + (Proven.) by OSHA, + (Proven.) by NIOSH [Ethylene
oxide]. Classified A2 (Suspected for human.) by ACGIH [Ethylene oxide].
4. First Aid Measures
INHALATION:
Remove to fresh air. If not breathing, give artifical respiration. If breathing is difficult, qualified personnel may give oxygen. Call a
physician.
SKIN CONTACT:
Immediately flush skin with plenty of water while removing contaminated clothing and shoes. Wash with soap and water. For
exposure to liquid, immediately warm frostbite area with warm water (not to exceed 42 C/105 F). In case of massive exposure,
remove clothing while showering with warm water. Call a physician. Wash contaminated clothing before re-use. Discard leather
goods and shoes.
SWALLOWING:
Give at least two glasses of water at once. Do not induce vomiting. Call a physician.
EYE CONTACT:
Immediately flush eyes with water for a least 15 minutes. See a physician, preferably an ophthalmologist, immediately.
NOTES TO PHYSICIAN:
Do not administer Adrenalin due to the sensitizing effect of fluorocarbons on the myocardium. Treatment of overexposure should be
directed at the control of symptoms and the clinical condition. (1)Persons exposed to ethylene oxide may develop severe and
intractable vomiting, requiring the use of antiemetics given intravenously. (2) Prolonged or high vapour concentrations exposure may
result in the development of pulmonary edema after a latent phase of several hours. Also, respiratory tract injury caused by ethylene
oxide may predispose to the development of a secondary respiratory infraction. Individuals exposed to moderately high vapour
concentrations of ethylene oxide should be retained for observation. (3) Following skin contamination, primary irritation and blister
formation may be delayed in onset. (4) When introduced directly into the blood stream ethylene oxide may act as a hapten and lead
to the development of anaphylactoid reactions of varying severity. This have been noted in a few haemodialysis and plasmapheresis
patients due to desorption of ethylene oxide from the sterilized equipment. There appears to be a close association to the presence
of lgE antibodies to albumin/ethylene oxide conjugates.
Copyright ?2001, Praxair Canada Inc. Page 2 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
5. Fire Fighting Measures
FLAMMABLE : IF YES, UNDER WHAT CONDITIONS?
Yes. Mixtures with air in the presence of ignition source.
FLASH POINT AUTOIGNITION Not available.
Not applicable.
(test method) TEMPERATURE
FLAMMABLE LIMITS LOWER: UPPER:
Not available. Not available.
IN AIR, % by volume:
EXTIGUISHING MEDIA:
In case of fire, use water spray (fog), foam, dry chemical, or CO2. Use alcohol foam, water spray or fog.
SPECIAL FIRE FIGHTING PROCEDURES:
WARNING! Evacuate all personnel from danger area. Immediately cool cylinders with water spray from maximum distance taking
care not to extinguish flames. Remove ignition source if without risk. If flames are accidentally extinguished. explosive
re-ignition may occur; therefore, appropriate measures should be taken; e.g., total evacuation. Reapproach with
extreme caution. Use self-contained breathing apparatus. Stop flow of gas if without risk while continuing cooling
water spray. Remove all containers from area if without risk. Allow fire to burn out. Dilution of ethylene oxide with 23
volumes of water renders it nonflammable, the manufacturer recommends dilution with 100 volumes of water as an
additional safe practice. Shut off source of fuel if possible. Withdraw immediately in case of rising sound from tank
car safety valve.
UNUSUAL FIRE AND EXPLOSION HAZARD:
Flammable gas. Forms explosive mixtures with air and oxidizing agents. Container may rupture due to heat of fire. Do not
extinguish flames due to possibility of explosive re-ignition. Vapours form from this product and may travel or be moved by air
currents an ignited by pilot lights, other flames, smoking, sparks, heaters, electrical equipment, static discharges, or other ignition
sources at locations distant from product handling point. Explosive atmospheres may linger. Before entering area, especially
confined areas, check atmosphere with approved device. No part of a container should be subjected to temperature higher than 52
C (approximately 125 F). Most containers are provided with a pressure relief device designed to vent contents when they are
exposed to elevated temperature.
HAZARDOUS COMBUSTION PRODUCTS:
These products are carbon oxides (CO, CO2)
SENSITIVITY TO IMPACT:
Avoid impact against container.
SENSITIVITY TO STATIC DISCHARGE:
Possible, ground containers.
6. Accidental Release Measures
STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED:
WARNING! Container may rupture due to heat of fire. No part of a container should be subjected to a temperature higher than
52 C. Containers are designed to vent contents when they are exposed to elevated temperature.
Under ordinary conditions, Oxyfume Sterilant Mixture 12 cannot catch fire. Controlled tests have shown that in the
event of a liquid spill and subsequent formation of a pool of liquid it is possible for some of the
Dichlorodifluomethane to boil off first, leaving behind a mixture enriched in Ethylene Oxide, This enriched mixture
may be flammable.
WASTE DISPOSAL METHOD:
Prevent waste from contaminating the surrounding environment. Keep personnel away. Discard any product, residue, disposable
container, or liner in an environmentally acceptable manner, in full compliance with federal, provincial, and local regulations. If
necessary, call your local supplier for assistance.
Copyright ?2001, Praxair Canada Inc. Page 3 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
7. Handling and Storage
PRECAUTIONS TO BE TAKEN IN STORAGE:
Store and use with adequate ventilation. Separate flammable cylinders from oxygen, chlorine, and other oxidizers by at least 6.1 m
or use a barricade of non-combustible material. This barricade should be at least 1.53 m high and have a fire resistance rating of
at least ?hour. Firmly secure cylinders upright to keep them from falling or being knocked over. Screw valve protection cap firmly
in place by hand. Post "No Smoking or Open Flames" signs in storage and use areas. There must be no sources of ignition. All
electrical equipment in storage areas must be explosion-proof. Storage areas must meet national electric codes for Class 1
hazardous areas. Store only where temperature will not exceed 52 C. Store full and empty cylinders separately. Use a first-in,
first-out inventory system to prevent storing full cylinders for long periods. For full details and requirements, see NFPA 50A,
published by the National Fire Protection Association.
PRECAUTIONS TO BE TAKEN IN HANDLING:
Protect cylinders from damage. Use a suitable hand truck to move cylinders; do not drag, roll, slide, or drop. Never attempt to lift a
cylinder by its cap; the cap is intended solely to protect the valve. Never insert an object (e.g., wrench, screwdriver, pry bar) into
cap openings; doing so may damage the valve and cause a leak. Use an adjustable strap wrench to remove over-tight or rusted
caps. Open valve slowly. If valve is hard to open, discontinue use and contact your supplier.
For additional information on stroage and handling, refer to Compressed Gas Association (CGA) pamphlet P-1, Safe Handling of
Compressed Gases in Containers, available from the CGA. Refer to section 16 for the address and phone number along with a list
of other available publications.
OTHER HAZARDOUS CONDITIONS OF HANDLING, STORAGE, AND USE:
Flammable high-pressure gas. Use only in a closed system. Use piping and equipment adequately designed to withstand pressures
and temperatures to be encountered. Use only spark-proof tools and explosion-proof equipment. Keep away from heat, open flame
and sparks. Gas can cause rapid suffocation due to oxygen deficiency. Store and use with adequate ventilation. Close valve after
each use; keep closed even when empty. Prevent reverse flow. Reverse flow into cylinder may cause rupture. Use a check valve or
other protective device in any line or piping from the cylinder. Never work on a pressurized system. If there is a leak, close the
cylinder valve. Blow the system down in an environmentally safe manner in compliance with all federal, provincial, and local laws,
then repair the leak. Never place a compressed gas cylinder where it may become part of an electrical circuit.
8. Exposure Controls/Personal Protection
VENTILATION/ENGINEERING CONTROLS:
LOCAL EXHAUST: Preferred. See SPECIAL.
MECHANICAL (general): Acceptable. See SPECIAL.
SPECIAL: Use only in a closed system. Ventilation should be designed in such a
manner that no person is exposed to concentrations of ethylene oxide
exceeding the TLV of 1ppm.
OTHER: See SPECIAL.
PERSONAL PROTECTION:
RESPIRATORY PROTECTION: Use respirable fume respirator or air supplied respirator when working
in confined space or where local exhaust or ventilation does not keep
exposure below TLV. Select in accordance with the provincial
regulations or guidelines. Selection should also be based on the current
CSA standards Z94.4, "Selection, care and use of respirators".
Respirators should be approved by NIOSH and MSHA.
SKIN PROTECTION: Butyl rubber. Gloves have a lifetime of approximately one half to one
hour after contact with liquid ethylene oxide.
EYE PROTECTION: Wear safety glasses when handling cylinders.
Select in accordance with the current CSA standard Z94.3, "Industrial
Eye and Face Protection", and any provincial regulations, local bylaws
or guidelines.
OTHER PROTECTIVE EQUIPMENT: Metatarsal shoes for cylinder handling. Protective clothing where
needed. Cuffless trousers should be worn outside the shoes. Select in
accordance with the current CSA standard Z195, "Protective Foot
Wear", and any provincial regulations, local bylaws or guidelines.
Copyright ?2001, Praxair Canada Inc. Page 4 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
9. Physical and Chemical Properties
PHYSICAL STATE: Gas. FREEZING POINT: Not available. pH: Not available.
BOILING POINT VAPOUR PRESSURE 68 psig MOLECULAR WEIGHT: Not applicable.
Not available.
SOLUBILITY IN WATER, Moderate. See Section VII.
SPECIFIC GRAVITY: 1.24
LIQUID ( Water = 1)
SPECIFIC GRAVITY: 2.82 EVAPORATION RATE High. COEFFICIENT OF WATER/OIL Not applicable.
DISTRIBUTION:
VAPOUR (Butyl Acetate=1):
(air = 1)
VAPOUR DENSITY: Not available. % VOLATILES BY 100% ODOUR THRESHOLD: Not available.
VOLUME:
APPEARANCE & ODOUR: Colourless gas at normal temperature and pressure. Ether-like odour in high concentrations.
10. Stability and Reactivity
STABILITY: The product is stable.
CONDITIONS OF CHEMICAL INSTABILITY: Elevated temperatures (the presence of certain
metals promote catalytic decomposition of the
Dichlorodifluoromethane component).
Dichlorodifluoromethane will decompose above
760 C. Mixture is stable at ordinary conditions of
temperature and pressure and in ordinary use
handling and storage. At higher temperatures
(ignition temperatures 463 C), is capable of
forming weakly combustible mixtures with air,
which do not propagate flame throughout the
mixture.
INCOMPATIBILITY (materials to avoid): Alkalies and acids; natural rubber, magnesium
and aluminum alloys containing more than 2%
magnesium. Strong oxidizers, mercaptans,
alkalai metals, alkaline earth metals, alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS: Thermal decomposition or burning may produce
carbon monoxide/carbon dioxide and toxic fumes
of fluorides and chlorides.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS OF REACTIVITY: Trace polymers may be present under ordinary
conditions of temperature, pressure, etc.
However, Ethylene Oxide will polymerize
violently if contaminated with aqueous alkalies,
amines, mineral acids, metal chlorides or metal
oxides. Avoid exposing stored cylinders to heat
or sources of ignition.
11. Toxicological Information
See section 3.
Copyright ?2001, Praxair Canada Inc. Page 5 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
12. Ecological Information
No adverse ecological effects expected. This product does not contain any Class I or Class II ozone-depleting chemicals. The
components of this mixture are not listed as marine pollutants by TDG regulations.
13. Disposal Considerations
WASTE DISPOSAL METHOD: Do not attempt to dispose of residual or unused quantities. Return cylinder to supplier.
14. Transport Information
TDG/IMO SHIPPING NAME: Compressed gas, flammable, n.o.s., (Ethylene Oxide)
HAZARD CLASS: Class 2.1: Flammable IDENTIFICATION #: PRODUCT RQ:
UN1954 100L
Gas
Flammable gas
SHIPPING LABEL(s):
Flammable gas
PLACARD (when required):
SPECIAL SHIPPING INFORMATION:
Cylinders should be transported in a secure position, in a well-ventilated vehicle. Cylinders transported in an enclosed, nonventilated
compartment of vehicle can present serious safety hazards.
15. Regulatory Information
The following selected regulatory requirements may apply to this product. Not all such requirements are identified. Users of this product are solely
responsible for compliance with all applicable federal, provincial, and local regulations.
CLASS A: Compressed gas.
WHMIS (Canada)
CLASS B-1: Flammable gas.
CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
International Regulations
Not available.
EINECS
R20- Harmful by inhalation.
DSCL (EEC)
R45- May cause cancer.
R46- May cause heritable genetic damage.
R60- May impair fertility.
No products were found.
International Lists
16. Other Information
MIXTURES:
When two or more gases, or liquefied gases are mixed, their hazardous properties may combine to create additional, unexpected
hazards. Obtain and evaluate the safety information for each component before you produce the mixture. Consult an Industrial
Hygienist, or other trained person when you make your safety evaluation of the end product. Remember, gases and liquids have
properties which can cause serious injury or death.
HAZARD RATING SYSTEM:
HMIS RATINGS:
HEALTH 0 *
FLAMMABILITY 4
REACTIVITY 0
*An Asterisk used in conjuction whith HMIS health hazards ratings
designates a carcinogenic or reproductive hazard.
STANDARD VALVE CONNECTIONS FOR U.S. AND CANADA:
THREADED: CGA-350
Copyright ?2001, Praxair Canada Inc. Page 6 of 7
Product Name: OXYFUME 12 MSDS# E-4799-J Date: 11/1/2001
PIN-INDEXED YOKE: Not available.
ULTRA-HIGH-INTEGRITY CONNECTION: Not available.
Use the proper CGA connections. DO NOT USE ADAPTERS. Additional limited-standard connections may apply. See CGA
pamphlets V-1 and V-7 listed below.
Ask your supplier about free Praxair safety literature as referred to in this MSDS and on the label for this product. Further
information about this product can be found in the following pamphlets published by the Compressed Gas Association, Inc. (CGA),
4221 Walney Road, 5th Floor, Chantilly, VA 20151-2923, Telephone (703) 788-2700, Fax (703) 934-1830, website:
www.cganet.com.
AV-1 Safe Handling and Storage of Compressed Gas
P-1 Safe Handling of Compressed Gases in Containers
V-1 Compressed Gas Cylinder Valve Inlet and Outlet Connections
V-7 Standard Method of Determining Cylinder Valve Outlet Connections for Industrial Gas Mixtures
--- Handbook of Compressed Gases, Fourth Edition
For more in-depth information for each component, refer to the pure product MSDS.
The information contained in this MSDS is generated from technical sources using the Chemmate Mixture
MSDS system and the pure-product MSDS for each component. These mixtures are not tested as a whole
for chemical, physical, or health effects.
PREPARATION INFORMATION:
DATE: 11/1/2001
DEPARTMENT: Safety and Environmental Services
TELEPHONE: 905-803-1600
The opinions expressed herein are those of qualified experts within Praxair Canada Inc. We believe that the information contained
herein is current as of the date of this Material Safety Data Sheet. Since the use of this information and the conditions of use of the
product are not within the control of Praxair Canada Inc., it is the user's obligation to determine the conditions of safe use of the product.
Praxair Canada Inc. requests the users of this product to study this Material Data Sheet (MSDS) and become aware of product hazards
and safety information. To promote safe use of this product, a user should (1) notify its employees, agents and contractors of the
information on this MSDS and any product hazards and safety nformation, (2) furnish this same information to each of its customers for
the product, and (3) request such customers to notify their employees and customers for the product of the same product hazards and
safety information.
Praxair and the Flowing Airstream design are trademarks of
Praxair Canada Inc.
Other trademarks used herein are trademarks or registered trademarks of their respective owners.
Praxair Canada Inc.
1 City Centre Drive
Suite 1200
Mississauga, ON L5B 1M2
Copyright ?2001, Praxair Canada Inc. Page 7 of 7
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