SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 19/JUL/2005
Date Updated: 29/APR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CYCLOSPORIN A, MOLECULAR BIOLOGY REAGENT
Product Number C1832
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CYCLOSPORIN A 59865-13-3 None None
Formula C62H111N11O12
Molecular Weight 1,202 AMU
Synonyms Antibiotic S 7481F1 * Cyclosporin * Cyclosporine
A * Neoral * OL 27-400 * Ramihyphin A * S 7481F1
* Sandimmun * Sandimmune
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Harmful if swallowed. May impair fertility.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
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MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Heat.
Materials to Avoid: Alkali metals, Aluminum, Strong oxidizing
agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GZ4120000
ACUTE TOXICITY
LD50
Oral
Rat
1480 mg/kg
Remarks: Behavioral:Muscle contraction or spasticity.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
LD50
Intraperitoneal
Rat
147 MG/KG
LD50
Subcutaneous
Rat
286 MG/KG
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LD50
Intravenous
Rat
24 MG/KG
LD50
Oral
Mouse
2329 mg/kg
Remarks: Behavioral:Muscle contraction or spasticity.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
LD50
Intravenous
Mouse
96 MG/KG
LD50
Oral
Rabbit
> 1000 mg/kg
Remarks: Behavioral:Muscle contraction or spasticity.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages:
Other: Hair.
LD50
Intravenous
Rabbit
10 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Cyclosporin A is a powerful immunosuppressant. Exposure may be
associated with the development of lymphomas. Other symptoms of
exposure may include hirsutism, rashes, gum hypertrophy,
angio-oedema, mild tremor, and hypertension. Absorption into the
body leads to the formation of methemoglobin which in sufficient
concentration causes cyanosis. Onset may be delayed 2 to 4 hours
or longer. Exposure can cause: Headache. Nausea. Vomiting.
Tremors. Diarrhea. Exposure may cause a rise in blood pressure.
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Immune system. Kidneys. Liver. Blood.
CHRONIC EXPOSURE - CARCINOGEN
Man
Route of Application: Oral
Exposure Time: 2W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease.
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IARC CARCINOGEN LIST
Rating: Group 1
CHRONIC EXPOSURE - MUTAGEN
Human
50 MG/L
Cell Type: lymphocyte
Other mutation test systems
Human
1 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat
Dose: 166 MG/KG
Route of Application: Subcutaneous
Exposure Time: (45D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Other effects on male. Effects on Fertility: Male
fertility index (e.g., # males impregnating females per # males
exposed to fertile nonpregnant females).
Species: Rat
Dose: 420 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 560 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects: Other
effects on male.
Species: Mouse
Dose: 90 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-8D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Rabbit
Dose: 210 MG/KG
Route of Application: Intramuscular
Exposure Time: (14D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes. Effects on
Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 22 60
May cause cancer. Harmful if swallowed. May impair fertility.
S-PHRASES: 53 45
Avoid exposure - obtain special instructions before use. In
case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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