SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 16/AUG/2005
Date Updated: 20/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name D-TUBOCURARINE CHLORIDE
Product Number T2379
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
(+)-TUBOCURARINE CHLORIDE 57-94-3 200-356-9 None
PENTAHYDRATE*
Formula C37H42Cl2N2O6
Molecular Weight 681.7 AMU
Synonyms Amerizol * Curarin-haf * Delacurarine *
Dextrotubocurarine chloride *
d-7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimeth
yltubocuraranium chloride * Intocostrin *
Intocostrine T * d-Paracurarine chloride *
Tubadil * Tubarine * Tubocurarine chloride *
Tubocurarine, chloride, hydrochloride, (+)-
(8CI) * d-Tubocurarine chloride * d-Tubocurarine
dichloride * Tubocurarine hydrochloride *
d-Tubocurarine hydrochloride
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8藲C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
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Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 275 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content 12 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YO4900000
ACUTE TOXICITY
LD50
Oral
Rat
28 mg/kg
LD50
Intraperitoneal
Rat
340 UG/KG
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Respiratory depression. Lungs, Thorax, or
Respiration:Other changes.
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LD50
Subcutaneous
Rat
310 UG/KG
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Respiratory depression. Lungs, Thorax, or
Respiration:Other changes.
LD50
Intravenous
Rat
66 UG/KG
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Respiratory depression. Lungs, Thorax, or
Respiration:Other changes.
LD50
Oral
Mouse
33 mg/kg
LD50
Intraperitoneal
Mouse
420 UG/KG
LD50
Subcutaneous
Mouse
640 UG/KG
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Respiratory depression. Lungs, Thorax, or
Respiration:Other changes.
LD50
Intravenous
Mouse
97 UG/KG
LD50
Intramuscular
Mouse
540 UG/KG
LD50
Intravenous
Rabbit
170 UG/KG
LD50
Intravenous
Guinea pig
66 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Lungs, Thorax, or Respiration:Other changes.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation. May be toxic in contact
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with skin.
Eye Contact: May cause eye irritation.
Inhalation: May be toxic by inhalation. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Nerves. Skeletal muscle.
CHRONIC EXPOSURE - MUTAGEN
ZINCL
Histidine reversion (Ames)
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1544
Class: 6.1
PG: II
Proper Shipping Name: Alkaloid salts, solid, n.o.s.
IMDG
UN#: 1544
Class: 6.1
PG: II
Proper Shipping Name: ALKALOID SALTS, SOLID, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1544
Class: 6.1
PG: II
Proper Shipping Name: Alkaloid salts, solid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25
Toxic if swallowed.
S-PHRASES: 45
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
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16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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